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Page 1
USP13: Multiple Functions and Target Inhibition.
Li X, Yang G, Zhang W, Qin B, Ye Z, Shi H, Zhao X, Chen Y, Song B, Mei Z, Zhao Q, Wang F. Li X, et al. Front Cell Dev Biol. 2022 Apr 4;10:875124. doi: 10.3389/fcell.2022.875124. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35445009 Free PMC article. Review.
Thus, dysregulation of USP13 can give rise to the occurrence and development of plenty of diseases, in particular malignant tumors. Given its implications in the stabilization of disease-related proteins and oncology targets, considerable efforts have been committed to the …
Thus, dysregulation of USP13 can give rise to the occurrence and development of plenty of diseases, in particular malignant tumors. G …
USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H, Liao C, Baldwin AS, Gong K, Zhang Q. Xie H, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2119854119. doi: 10.1073/pnas.2119854119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037364 Free PMC article.
As a result, USP13 promoted ZHX2 protein stability in an enzymatically dependent manner, and depletion of USP13 led to ZHX2 down-regulation in ccRCC. ...Our findings support that USP13 may be a key effector in ccRCC tumorigenesis....
As a result, USP13 promoted ZHX2 protein stability in an enzymatically dependent manner, and depletion of USP13 led to ZHX2 do …
Role of USP13 in physiology and diseases.
Wang Q, Sun Z, Xia W, Sun L, Du Y, Zhang Y, Jia Z. Wang Q, et al. Front Mol Biosci. 2022 Sep 14;9:977122. doi: 10.3389/fmolb.2022.977122. eCollection 2022. Front Mol Biosci. 2022. PMID: 36188217 Free PMC article. Review.
Ubiquitin specific protease (USP)-13 is a deubiquitinase that removes ubiquitin from substrates to prevent protein degradation by the proteasome. Currently, the roles of USP13 in physiology and pathology have been reported. In physiology, USP13 is highly associated …
Ubiquitin specific protease (USP)-13 is a deubiquitinase that removes ubiquitin from substrates to prevent protein degradation by the protea …
N(6)-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors.
Gao Z, Li C, Sun H, Bian Y, Cui Z, Wang N, Wang Z, Yang Y, Liu Z, He Z, Li B, Li F, Li Z, Wang L, Zhang D, Yang L, Xu Z, Li X, Xu H. Gao Z, et al. Cell Death Differ. 2023 Feb;30(2):544-559. doi: 10.1038/s41418-022-01107-8. Epub 2022 Dec 17. Cell Death Differ. 2023. PMID: 36528756 Free PMC article.
Activation of PAK1 promoted phosphorylation of ATG5 thereby enhancing the interaction of ATG5 with USP13. Furthermore, N(6)-methyladenosine methyltransferase-like 3 (METTL3) mediated stabilization of USP13 mRNA that required the m(6)A reader IGF2BP2. ...Our findings …
Activation of PAK1 promoted phosphorylation of ATG5 thereby enhancing the interaction of ATG5 with USP13. Furthermore, N(6)-methylade …
USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity.
Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, Han C. Kwon J, et al. Mol Cancer. 2023 Dec 13;22(1):204. doi: 10.1186/s12943-023-01892-x. Mol Cancer. 2023. PMID: 38093367 Free PMC article.
We found that USP13 altered lineage-determining factors such as NKX2-1 and SOX2 in club cells of the airway and reinforced the fate of club cells to squamous carcinoma development. We showed a strong molecular association between USP13 and c-MYC, leading to the upre …
We found that USP13 altered lineage-determining factors such as NKX2-1 and SOX2 in club cells of the airway and reinforced the fate o …
Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m(6)A/ATG5 axis.
Wang C, Meng Y, Zhao J, Ma J, Zhao Y, Gao R, Liu W, Zhou X. Wang C, et al. Int J Biol Sci. 2023 Apr 23;19(7):2289-2303. doi: 10.7150/ijbs.82081. eCollection 2023. Int J Biol Sci. 2023. PMID: 37151889 Free PMC article.
Since METTL3 is a well-known m(6)A writer and USP13 stabilizes METTL3, we further found that USP13 increased global m(6)A abundance in OS cells. ...Our findings demonstrate the role of the USP13-METTL3-ATG5 cascade in OS progression and show that USP13 …
Since METTL3 is a well-known m(6)A writer and USP13 stabilizes METTL3, we further found that USP13 increased global m(6)A abun …
USP13 Deficiency Impairs Autophagy and Facilitates Age-related Lung Fibrosis.
Liu Y, Li Z, Xiao H, Xie B, He J, Song M, Wang J, Geng J, Dai H, Wang C. Liu Y, et al. Am J Respir Cell Mol Biol. 2023 Jan;68(1):49-61. doi: 10.1165/rcmb.2022-0002OC. Am J Respir Cell Mol Biol. 2023. PMID: 36150040
Mechanistically, USP13 interacted with and deubiquitinated Beclin 1, and Beclin 1 overexpression abolished the effects of USP13 disruption. In addition, Beclin 1 inhibition resulted in insufficient autophagy and more severe lung fibrosis after bleomycin injury, cons …
Mechanistically, USP13 interacted with and deubiquitinated Beclin 1, and Beclin 1 overexpression abolished the effects of USP13 …
USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination.
Zhao B, Huo W, Yu X, Shi X, Lv L, Yang Y, Kang J, Li S, Wu H. Zhao B, et al. Cell Oncol (Dordr). 2023 Jun;46(3):717-733. doi: 10.1007/s13402-023-00779-9. Epub 2023 Feb 3. Cell Oncol (Dordr). 2023. PMID: 36732432 Free PMC article.
In addition, we found that the protein levels of Twist1 dose-dependently increased with USP13 overexpression, while USP13 knockdown resulted in a decreased expression of endogenous Twist1. ...We found that the effect of USP13 in promoting the migration and in …
In addition, we found that the protein levels of Twist1 dose-dependently increased with USP13 overexpression, while USP13 knoc …
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Ma C, Wang D, Tian Z, Gao W, Zang Y, Qian L, Xu X, Jia J, Liu Z. Ma C, et al. Oncogene. 2023 Jul;42(29):2249-2262. doi: 10.1038/s41388-023-02739-x. Epub 2023 Jun 13. Oncogene. 2023. PMID: 37311811 Free PMC article.
Conversely, suppression of USP13 led to GC cell cycle arrest in G1 phase and the inhibition of cell proliferation. ...These findings suggest that USP13 might be a promising therapeutic target for the treatment of GC....
Conversely, suppression of USP13 led to GC cell cycle arrest in G1 phase and the inhibition of cell proliferation. ...These findings …
USP13 regulates cell senescence through mediating MDM2 stability.
He J, Baoyinna B, Taleb SJ, Zhao J, Zhao Y. He J, et al. Life Sci. 2023 Oct 15;331:122044. doi: 10.1016/j.lfs.2023.122044. Epub 2023 Aug 25. Life Sci. 2023. PMID: 37634814 Free PMC article.
The increased protein levels of MDM2 were detected in lung tissues of USP13 deficient mice. Furthermore, overexpression of USP13 promoted cell senescence. Knockdown of USP13 increased MDM2 levels in lung cells, while overexpression of USP13 reduced it. …
The increased protein levels of MDM2 were detected in lung tissues of USP13 deficient mice. Furthermore, overexpression of USP13 …
119 results