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Characterization of paralogous uncx transcription factor encoding genes in zebrafish.
Nittoli V, Fortunato AE, Fasano G, Coppola U, Gentile A, Maiella S, Langellotto F, Porreca I, De Paolo R, Marino R, Fiengo M, Donizetti A, Aniello F, Kondo T, Ristoratore F, Canzoniero LMT, Duboule D, Wilson SW, Sordino P. Nittoli V, et al. Gene. 2019;721S:100011. doi: 10.1016/j.gene.2019.100011. Epub 2019 Mar 8. Gene. 2019. PMID: 34530988 Free article.
The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expres …
The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning th …
Characterization of paralogous uncx transcription factor encoding genes in zebrafish.
Nittoli V, Fortunato AE, Fasano G, Coppola U, Gentile A, Maiella S, Langellotto F, Porreca I, De Paolo R, Marino R, Fiengo M, Donizetti A, Aniello F, Kondo T, Ristoratore F, Canzoniero LMT, Duboule D, Wilson SW, Sordino P. Nittoli V, et al. Gene X. 2019 Jun;2:100011. doi: 10.1016/j.gene.2019.100011. Gene X. 2019. PMID: 31193955 Free PMC article.
The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expres …
The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning th …
Identification of a Functional Susceptibility Variant for Adolescent Idiopathic Scoliosis that Upregulates Early Growth Response 1 (EGR1)-Mediated UNCX Expression.
Yonezawa Y, Guo L, Kakinuma H, Otomo N, Yoshino S, Takeda K, Nakajima M, Shiraki T, Ogura Y, Takahashi Y, Koike Y, Minami S, Uno K, Kawakami N, Ito M, Yonezawa I, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Sato T, Inami S, Nakamura M, Matsumoto M, Terao C, Watanabe K, Okamoto H, Ikegawa S. Yonezawa Y, et al. J Bone Miner Res. 2023 Jan;38(1):144-153. doi: 10.1002/jbmr.4738. Epub 2022 Nov 23. J Bone Miner Res. 2023. PMID: 36342191 Free article.
In this study, we evaluated the AIS-associated variants in the 7p22.3 locus by combining in silico, in vitro, and in vivo analyses. rs78148157 was located in an enhancer of UNCX, a homeobox gene and its risk allele upregulated the UNCX expression. A transcription fa …
In this study, we evaluated the AIS-associated variants in the 7p22.3 locus by combining in silico, in vitro, and in vivo analyses. rs781481 …
Antagonistic regulation of homeologous uncx.L and uncx.S genes orchestrates myotome and sclerotome differentiation in the evolutionarily divergent vertebral column of Xenopus laevis.
Sánchez RS, Lazarte MA, Abdala VSL, Sánchez SS. Sánchez RS, et al. J Exp Zool B Mol Dev Evol. 2023 Dec 28. doi: 10.1002/jez.b.23235. Online ahead of print. J Exp Zool B Mol Dev Evol. 2023. PMID: 38155515
Comparative analysis of the messenger RNA sequences of homeologous uncx genes revealed that the uncx.L variant lacks the eh1-like repressor domain. ...Our findings suggest a scenario where the homeologous genes uncx.L and uncx.S exhibit antagonistic fu …
Comparative analysis of the messenger RNA sequences of homeologous uncx genes revealed that the uncx.L variant lacks the eh1-l …
Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.
Sammeta N, Hardin DL, McClintock TS. Sammeta N, et al. Mol Cell Neurosci. 2010 Dec;45(4):398-407. doi: 10.1016/j.mcn.2010.07.013. Epub 2010 Aug 6. Mol Cell Neurosci. 2010. PMID: 20692344 Free PMC article.
Uncx (Phd1, Chx4) is a paired homeobox transcription factor gene. ...In Uncx(-/-) mice olfactory progenitor cell proliferation, progenitor cell number, olfactory sensory neuron survival, and Umodl1 and Kcnc4 mRNAs were reduced. ...
Uncx (Phd1, Chx4) is a paired homeobox transcription factor gene. ...In Uncx(-/-) mice olfactory progenitor cell proliferation …
Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells.
Daniele G, Simonetti G, Fusilli C, Iacobucci I, Lonoce A, Palazzo A, Lomiento M, Mammoli F, Marsano RM, Marasco E, Mantovani V, Quentmeier H, Drexler HG, Ding J, Palumbo O, Carella M, Nadarajah N, Perricone M, Ottaviani E, Baldazzi C, Testoni N, Papayannidis C, Ferrari S, Mazza T, Martinelli G, Storlazzi CT. Daniele G, et al. Haematologica. 2017 Jul;102(7):1204-1214. doi: 10.3324/haematol.2016.163022. Epub 2017 Apr 14. Haematologica. 2017. PMID: 28411256 Free PMC article.
We here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia (AML). ...UNCX-positive and -negative patients displayed significant differences in their gene expression profiles. ...
We here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia (AML) …
Characterization of pax1, pax9, and uncx sclerotomal genes during Xenopus laevis embryogenesis.
Sánchez RS, Sánchez SS. Sánchez RS, et al. Dev Dyn. 2013 May;242(5):572-9. doi: 10.1002/dvdy.23945. Epub 2013 Mar 27. Dev Dyn. 2013. PMID: 23401059 Free article.
RESULTS: In this work, we cloned and examined through whole-mount in situ hybridization and reverse transcriptase-polymerase chain reaction the expression patterns of pax1, pax9, and uncx transcription factors in the anuran Xenopus laevis. CONCLUSIONS: We found that these …
RESULTS: In this work, we cloned and examined through whole-mount in situ hybridization and reverse transcriptase-polymerase chain reaction …
Spatial transcriptomics reveals a conserved segment polarity program that governs muscle patterning in Nematostella vectensis.
He S, Shao W, Chen SC, Wang T, Gibson MC. He S, et al. bioRxiv [Preprint]. 2023 Jan 10:2023.01.09.523347. doi: 10.1101/2023.01.09.523347. bioRxiv. 2023. PMID: 36711919 Free PMC article. Updated. Preprint.
Capitalizing on accurate in silico predictions, we identified Lbx and Uncx, conserved homeodomain-containing genes that occupy opposing subsegmental domains under the control of both BMP signaling and the Hox-Gbx cascade. ...HIGHLIGHTS: Nematostella endomesodermal tissue f …
Capitalizing on accurate in silico predictions, we identified Lbx and Uncx, conserved homeodomain-containing genes that occupy opposi …
Spatial transcriptomics reveals a cnidarian segment polarity program in Nematostella vectensis.
He S, Shao W, Chen SC, Wang T, Gibson MC. He S, et al. Curr Biol. 2023 Jul 10;33(13):2678-2689.e5. doi: 10.1016/j.cub.2023.05.044. Epub 2023 Jun 13. Curr Biol. 2023. PMID: 37315559
Capitalizing on accurate in silico predictions, we identified Lbx and Uncx, conserved homeodomain-containing genes that occupy opposing subsegmental domains under the control of both bone morphogenetic protein (BMP) signaling and the Hox-Gbx cascade. ...
Capitalizing on accurate in silico predictions, we identified Lbx and Uncx, conserved homeodomain-containing genes that occupy opposi …
DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging.
Zoller JA, Parasyraki E, Lu AT, Haghani A, Niehrs C, Horvath S. Zoller JA, et al. Geroscience. 2024 Feb;46(1):945-960. doi: 10.1007/s11357-023-00840-3. Epub 2023 Jun 4. Geroscience. 2024. PMID: 37270437 Free PMC article.
Highly conserved positively age-related CpGs are located in neural-developmental genes such as uncx, tfap2d as well as nr4a2 implicated in age-associated disease. ...
Highly conserved positively age-related CpGs are located in neural-developmental genes such as uncx, tfap2d as well as nr4a2 implicat …
27 results