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2005 2
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2008 3
2009 3
2011 1
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2013 11
2014 8
2015 4
2016 5
2017 7
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2020 7
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2023 17
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91 results

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Page 1
UBR4 deficiency causes male sterility and testis abnormal in Drosophila.
Xie SM, Lai JX, Liu CQ, Zhang XX, Lin YM, Lan QW, Hong DY, Chen XC, Qiao JD, Mao YL. Xie SM, et al. Front Endocrinol (Lausanne). 2023 Jul 10;14:1165825. doi: 10.3389/fendo.2023.1165825. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37529615 Free PMC article.
Herein, we explored the role of UBR4 on fertility with a Drosophila model. METHODS: Different Ubr4 knockdown flies were established using the UAS/GAL4 activating sequence system. ...RESULTS: We found that Ubr4 deficiency affected the testis during morphologic …
Herein, we explored the role of UBR4 on fertility with a Drosophila model. METHODS: Different Ubr4 knockdown flies were establ …
UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony.
Hegazi S, Cheng AH, Krupp JJ, Tasaki T, Liu J, Szulc DA, Ling HH, Rios Garcia J, Seecharran S, Basiri T, Amiri M, Anwar Z, Ahmad S, Nayal K, Sonenberg N, Liu BH, Cheng HM, Levine JD, Cheng HM. Hegazi S, et al. Nat Commun. 2022 Mar 24;13(1):1594. doi: 10.1038/s41467-022-29244-1. Nat Commun. 2022. PMID: 35332162 Free PMC article.
Ubr4-deficient mice are resistant to jetlag, whereas poe knockdown flies are prone to arrhythmicity, behaviors reflective of the reduced axonal trafficking of circadian neuropeptides. At the cellular level, Ubr4 ablation impairs the export of secreted proteins from …
Ubr4-deficient mice are resistant to jetlag, whereas poe knockdown flies are prone to arrhythmicity, behaviors reflective of the redu …
UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma.
Kuser-Abali G, Zhang Y, Szeto P, Zhao P, Masoumi-Moghaddam S, Fedele CG, Leece I, Huang C, Cheung JG, Ameratunga M, Noguchi F, Andrews MC, Wong NC, Schittenhelm RB, Shackleton M. Kuser-Abali G, et al. Oncogene. 2023 Apr;42(17):1360-1373. doi: 10.1038/s41388-023-02631-8. Epub 2023 Mar 11. Oncogene. 2023. PMID: 36906655 Free PMC article.
Biochemical assays and animal studies demonstrated that in LPCs, the E2-conjugating enzyme UBE2L6 depletes EZH2 protein in cooperation with UBR4, an E3 ligase, via ubiquitination at EZH2's K381 residue, and is downregulated in LPCs by UHRF1-mediated CpG methylation. Target …
Biochemical assays and animal studies demonstrated that in LPCs, the E2-conjugating enzyme UBE2L6 depletes EZH2 protein in cooperation with …
p600/UBR4 in the central nervous system.
Parsons K, Nakatani Y, Nguyen MD. Parsons K, et al. Cell Mol Life Sci. 2015 Mar;72(6):1149-60. doi: 10.1007/s00018-014-1788-8. Epub 2014 Nov 26. Cell Mol Life Sci. 2015. PMID: 25424645 Review.
A decade ago, the large 600 kDa mammalian protein p600 (also known as UBR4) was discovered as a multifunctional protein with roles in anoikis, viral transformation and protein degradation. ...
A decade ago, the large 600 kDa mammalian protein p600 (also known as UBR4) was discovered as a multifunctional protein with roles in …
P65 mediated UBR4 in exosomes derived from menstrual blood stromal cells to reduce endometrial fibrosis by regulating YAP Ubiquitination.
Qi J, Zhang X, Zhang S, Wu S, Lu Y, Li S, Li P, Tan J. Qi J, et al. J Nanobiotechnology. 2023 Aug 29;21(1):305. doi: 10.1186/s12951-023-02070-3. J Nanobiotechnology. 2023. PMID: 37644565 Free PMC article.
RESULTS: UBR4 was lowly expressed in the endometrial stromal cells (EndoSCs) of IUA patients. ...Moreover, P65 could bind to the UBR4 promoter region to transcriptionally promote the expression level of UBR4 in MenSCs. ...
RESULTS: UBR4 was lowly expressed in the endometrial stromal cells (EndoSCs) of IUA patients. ...Moreover, P65 could bind to the U …
Aberrant UBR4 expressions in Hirschsprung disease patients.
Gunadi, Kalim AS, Liana E, Fauzi AR, Sirait DN, Afandy D, Kencana SMS, Purnomo E, Iskandar K, Makhmudi A. Gunadi, et al. BMC Pediatr. 2019 Dec 12;19(1):493. doi: 10.1186/s12887-019-1879-7. BMC Pediatr. 2019. PMID: 31830949 Free PMC article.
We determined the UBR4 expressions in Indonesian HSCR patients. METHODS: We analyzed the UBR4 expressions in the colons of HSCR patient and anorectal malformation (ARM) patient as control by real-time polymerase chain reaction (qPCR). ...CONCLUSION: Our study demons …
We determined the UBR4 expressions in Indonesian HSCR patients. METHODS: We analyzed the UBR4 expressions in the colons of HSC …
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.
Cervia LD, Shibue T, Borah AA, Gaeta B, He L, Leung L, Li N, Moyer SM, Shim BH, Dumont N, Gonzalez A, Bick NR, Kazachkova M, Dempster JM, Krill-Burger JM, Piccioni F, Udeshi ND, Olive ME, Carr SA, Root DE, McFarland JM, Vazquez F, Hahn WC. Cervia LD, et al. Cancer Discov. 2023 Mar 1;13(3):766-795. doi: 10.1158/2159-8290.CD-22-1230. Cancer Discov. 2023. PMID: 36576405 Free PMC article.
We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality modules and found that a ubiquitin ligase complex composed of UBA6, BIRC6, KCMF1, and UBR4 is required for the survival of a subset of epithelial tumors that exhibit a hi …
We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality modules and found that a ubiquitin li …
Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis.
Feng L, Liu T, Shi J, Wang Y, Yang Y, Xiao W, Bai Y. Feng L, et al. Open Med (Wars). 2023 Aug 30;18(1):20230751. doi: 10.1515/med-2023-0751. eCollection 2023. Open Med (Wars). 2023. PMID: 37693837 Free PMC article.
The aim of our study is to disclose the role and underlying molecular mechanisms of circular RNA ubiquitin protein ligase E3 component n-recognin 4 (circ-UBR4) in atherosclerosis (AS). Our data showed that circ-UBR4 expression was upregulated in AS patients and oxid …
The aim of our study is to disclose the role and underlying molecular mechanisms of circular RNA ubiquitin protein ligase E3 component n-rec …
Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging.
Hunt LC, Schadeberg B, Stover J, Haugen B, Pagala V, Wang YD, Puglise J, Barton ER, Peng J, Demontis F. Hunt LC, et al. Nat Commun. 2021 Mar 3;12(1):1418. doi: 10.1038/s41467-021-21738-8. Nat Commun. 2021. PMID: 33658508 Free PMC article.
A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but such model has not been extensively tested. Here, we find that the levels of the ubiquitin ligase UBR4 increase in skeletal muscle with aging, and that UBR4 …
A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but such model has not been ex …
Circ_UBR4 Knockdown Alleviates Oxidized Low-Density Lipoprotein-Provoked Growth and Migration of Human Vascular Smooth Muscle Cells by Acting on the miR-637/FOXO4 Pathway.
Ding Y, Tang T, Lu J, Wang J. Ding Y, et al. J Cardiovasc Pharmacol. 2021 Oct 1;78(4):534-543. doi: 10.1097/FJC.0000000000001098. J Cardiovasc Pharmacol. 2021. PMID: 34225339
Cell cycle progression, cell proliferation, and cell migration were promoted by ox-LDL, whereas circ_UBR4 knockdown inhibited HVSMCs proliferation and migration. MiR-637 was a target of circ_UBR4, and FOXO4 was a target of miR-637. Circ_UBR4 positively regula …
Cell cycle progression, cell proliferation, and cell migration were promoted by ox-LDL, whereas circ_UBR4 knockdown inhibited HVSMCs …
91 results