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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
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2007 40
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2009 52
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1,174 results

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Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment.
Li Q, Zhao Y, Guo H, Li Q, Yan C, Li Y, He S, Wang N, Wang Q. Li Q, et al. Autophagy. 2023 Oct;19(10):2639-2656. doi: 10.1080/15548627.2023.2213984. Epub 2023 May 19. Autophagy. 2023. PMID: 37204119 Free PMC article.
Mechanistically, accumulated LDs colocalized with the microglial specific inflammatory amplifier TREM1 (triggering receptor expressed on myeloid cells 1), resulting in the buildup of microglial TREM1, which in turn aggravates HG-induced lipophagy damage and subseque …
Mechanistically, accumulated LDs colocalized with the microglial specific inflammatory amplifier TREM1 (triggering receptor expressed …
TREM1 activation of myeloid cells promotes antitumor immunity.
Juric V, Mayes E, Binnewies M, Lee T, Canaday P, Pollack JL, Rudolph J, Du X, Liu VM, Dash S, Palmer R, Jahchan NS, Ramoth ÅJ, Lacayo S, Mankikar S, Norng M, Brassell C, Pal A, Chan C, Lu E, Sriram V, Streuli M, Krummel MF, Baker KP, Liang L. Juric V, et al. Sci Transl Med. 2023 Aug 30;15(711):eadd9990. doi: 10.1126/scitranslmed.add9990. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647386
We developed PY159, an afucosylated humanized anti-TREM1 monoclonal antibody with enhanced FcgammaR binding. PY159 is a TREM1 agonist that induces signaling, leading to up-regulation of costimulatory molecules on monocytes and macrophages, production of proinflammat …
We developed PY159, an afucosylated humanized anti-TREM1 monoclonal antibody with enhanced FcgammaR binding. PY159 is a TREM1 …
Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti-PD-1 resistance.
Ajith A, Mamouni K, Horuzsko DD, Musa A, Dzutsev AK, Fang JR, Chadli A, Zhu X, Lebedyeva I, Trinchieri G, Horuzsko A. Ajith A, et al. J Clin Invest. 2023 Nov 1;133(21):e167951. doi: 10.1172/JCI167951. J Clin Invest. 2023. PMID: 37651197 Free PMC article.
We examined whether loss of TREM1 signaling can abrogate the immunosuppressive TME and enhance cancer immunity. To investigate the therapeutic potential of TREM1 in cancer, we used mice deficient in Trem1 and developed a novel small molecule TREM1 inhi …
We examined whether loss of TREM1 signaling can abrogate the immunosuppressive TME and enhance cancer immunity. To investigate the th …
Inhibition of TREM1 reduces inflammation and oxidative stress after spinal cord injury (SCI) associated with HO-1 expressions.
Li Z, Wu F, Xu D, Zhi Z, Xu G. Li Z, et al. Biomed Pharmacother. 2019 Jan;109:2014-2021. doi: 10.1016/j.biopha.2018.08.159. Epub 2018 Nov 26. Biomed Pharmacother. 2019. PMID: 30551457 Free article.
In the present study, we attempted to explore the effects of TREM1 on the regulation of SCI. Spinal cord contusion injury was performed in wild type (WT) and TREM1-knockout (TREM1(KO)) mice, and real time-quantitative PCR (RT-qPCR), western blot, and immunofl …
In the present study, we attempted to explore the effects of TREM1 on the regulation of SCI. Spinal cord contusion injury was perform …
Function of TREM1 and TREM2 in Liver-Related Diseases.
Sun H, Feng J, Tang L. Sun H, et al. Cells. 2020 Dec 7;9(12):2626. doi: 10.3390/cells9122626. Cells. 2020. PMID: 33297569 Free PMC article. Review.
TREM1 and TREM2 are members of the triggering receptors expressed on myeloid cells (TREM) family. ...The function of TREM1 and TREM2 in inflammatory response depends on Toll-like receptor 4. ...
TREM1 and TREM2 are members of the triggering receptors expressed on myeloid cells (TREM) family. ...The function of TREM1 and …
Single-cell RNA sequencing identifies an Il1rn(+)/Trem1(+) macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection.
Liu X, Chen W, Zhu G, Yang H, Li W, Luo M, Shu C, Zhou Z. Liu X, et al. Cell Discov. 2022 Feb 8;8(1):11. doi: 10.1038/s41421-021-00362-2. Cell Discov. 2022. PMID: 35132073 Free PMC article.
Suppression of macrophage accumulation in the aorta with Ki20227 could significantly decrease the incidence of TAAD and aortic rupture in mice. Targeting the Il1rn(+)/Trem1(+) macrophage subpopulation via blockade of Trem1 using mLR12 could significantly decrease th …
Suppression of macrophage accumulation in the aorta with Ki20227 could significantly decrease the incidence of TAAD and aortic rupture in mi …
The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study.
Shi X, Wei T, Hu Y, Wang M, Tang Y. Shi X, et al. J Neuroinflammation. 2022 Sep 6;19(1):218. doi: 10.1186/s12974-022-02582-z. J Neuroinflammation. 2022. PMID: 36068612 Free PMC article.
BACKGROUND: Triggering receptor expressed on myeloid cell 1 (Trem1) is an important regulator of cellular inflammatory responses. Neuroinflammation is a common thread across various neurological diseases. Soluble Trem1 (sTrem1) in plasma is associated with the devel …
BACKGROUND: Triggering receptor expressed on myeloid cell 1 (Trem1) is an important regulator of cellular inflammatory responses. Neu …
Overexpression of TREM1 is Associated with the Immune-Suppressive Microenvironment and Unfavorable Prognosis in Pan-Cancer.
Zhou X, Lin K, Fu L, Liu F, Lin H, Chen Y, Zhuang B, Liang H, Deng Q, Wang Z, Chen W, Luo J, Cao J, Li P. Zhou X, et al. J Inflamm Res. 2023 Mar 27;16:1375-1391. doi: 10.2147/JIR.S398284. eCollection 2023. J Inflamm Res. 2023. PMID: 37006813 Free PMC article.
Survival analysis was performed to determine the prognostic value of TREM1. Functional enrichment analysis was applied to decipher the discrepancy in biological processes between high- and low-TREM1 groups across various cancers. ...Four independent immunotherapy co …
Survival analysis was performed to determine the prognostic value of TREM1. Functional enrichment analysis was applied to decipher th …
TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization.
Yu C, Zhou G, Shi Z, Yu L, Zhou X. Yu C, et al. Dig Liver Dis. 2023 Dec 26:S1590-8658(23)01082-4. doi: 10.1016/j.dld.2023.12.002. Online ahead of print. Dig Liver Dis. 2023. PMID: 38151453
This work uncovered the effects and mechanism of TREM1 in GC. IHC staining examined TREM1 expression in GC tissues. TREM1-knockout and TREM1 knock-in mice were generated prior to the construction of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced G …
This work uncovered the effects and mechanism of TREM1 in GC. IHC staining examined TREM1 expression in GC tissues. TREM1 …
PET imaging of TREM1 identifies CNS-infiltrating myeloid cells in a mouse model of multiple sclerosis.
Chaney AM, Cropper HC, Jain P, Wilson E, Simonetta F, Johnson EM, Alam IS, Patterson ITJ, Swarovski M, Stevens MY, Wang Q, Azevedo C, Nagy SC, Ramos Benitez J, Deal EM, Vogel H, Andreasson KI, James ML. Chaney AM, et al. Sci Transl Med. 2023 Jun 28;15(702):eabm6267. doi: 10.1126/scitranslmed.abm6267. Epub 2023 Jun 28. Sci Transl Med. 2023. PMID: 37379371
We first validated TREM1 as a specific marker of proinflammatory, CNS-infiltrating, peripheral myeloid cells in mice with EAE. ...We illustrate the therapeutic potential of attenuating TREM1 signaling both genetically and pharmacologically in the EAE mice and show t …
We first validated TREM1 as a specific marker of proinflammatory, CNS-infiltrating, peripheral myeloid cells in mice with EAE. ...We …
1,174 results