Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 1
1998 3
1999 1
2000 2
2001 1
2002 2
2003 2
2004 5
2006 2
2007 2
2008 2
2009 4
2010 6
2011 8
2012 6
2013 16
2014 18
2015 14
2016 6
2017 10
2018 7
2019 6
2020 9
2021 10
2022 6
2023 7
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

142 results

Results by year

Filters applied: . Clear all
Page 1
TRA2B Gene Splice Variant Linked to Seizures and Neurodevelopmental Delay: A Second Case Study.
Shatokhina O, Kovalskaia V, Sparber P, Sharkova I, Mishina I, Kuznetsova V, Ryzhkova O. Shatokhina O, et al. Int J Mol Sci. 2023 Oct 25;24(21):15572. doi: 10.3390/ijms242115572. Int J Mol Sci. 2023. PMID: 37958557 Free PMC article.
In this study, we report a novel splice variant in the TRA2B gene identified in a patient presenting with seizures and neurodevelopmental delay. ...These findings contribute to the dissemination and reinforcement of prior discoveries in the context of TRA2B-related …
In this study, we report a novel splice variant in the TRA2B gene identified in a patient presenting with seizures and neurodevelopme …
Clustered variants in the 5' coding region of TRA2B cause a distinctive neurodevelopmental syndrome.
Ramond F, Dalgliesh C, Grimmel M, Wechsberg O, Vetro A, Guerrini R, FitzPatrick D, Poole RL, Lebrun M, Bayat A, Grasshoff U, Bertrand M, Witt D, Turnpenny PD, Faundes V, Santa María L, Mendoza Fuentes C, Mabe P, Hussain SA, Mullegama SV, Torti E, Oehl-Jaschkowitz B, Salmon LB, Orenstein N, Shahar NR, Hagari O, Bazak L, Hoffjan S, Prada CE, Haack T, Elliott DJ. Ramond F, et al. Genet Med. 2023 Apr;25(4):100003. doi: 10.1016/j.gim.2022.100003. Epub 2022 Dec 20. Genet Med. 2023. PMID: 36549593 Free article.
The aim of this work was to associate germline variants in the TRA2B gene to a novel neurodevelopmental disorder. METHODS: A total of 12 individuals from 11 unrelated families who harbored predicted loss-of-function monoallelic variants, mostly de novo, were recruited. ... …
The aim of this work was to associate germline variants in the TRA2B gene to a novel neurodevelopmental disorder. METHODS: A total of …
Splicing factor TRA2B is required for neural progenitor survival.
Roberts JM, Ennajdaoui H, Edmondson C, Wirth B, Sanford JR, Chen B. Roberts JM, et al. J Comp Neurol. 2014 Feb 1;522(2):372-92. doi: 10.1002/cne.23405. J Comp Neurol. 2014. PMID: 23818142 Free PMC article.
Using cortex-specific Tra2b mutant mice, we show that TRA2B depletion results in apoptosis of the neural progenitor cells as well as disorganization of the cortical plate. Thus, TRA2B is essential for proper development of the cerebral cortex....
Using cortex-specific Tra2b mutant mice, we show that TRA2B depletion results in apoptosis of the neural progenitor cells as w …
Expression of TRA2B in endometrial carcinoma and its regulatory roles in endometrial carcinoma cells.
Paudel D, Ouyang Y, Huang Q, Zhou W, Wang J, Poorekhorsandi ME, Dhakal B, Tong X. Paudel D, et al. Oncol Lett. 2019 Sep;18(3):2455-2463. doi: 10.3892/ol.2019.10553. Epub 2019 Jul 3. Oncol Lett. 2019. PMID: 31452736 Free PMC article.
Expression levels of Transformer 2 protein homolog beta (TRA2B) in patients with endometrial carcinoma were assessed to investigate the impact of TRA2B on endometrial carcinoma cells. ...Endometrial carcinoma cells were transfected with chemically synthesized TRA …
Expression levels of Transformer 2 protein homolog beta (TRA2B) in patients with endometrial carcinoma were assessed to investigate t …
HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells.
Nishikawa T, Kuwano Y, Takahara Y, Nishida K, Rokutan K. Nishikawa T, et al. Sci Rep. 2019 Jul 16;9(1):10276. doi: 10.1038/s41598-019-46659-x. Sci Rep. 2019. PMID: 31311954 Free PMC article.
The human TRA2B gene consists of 10 exons and 9 introns and produces 5 splice isoforms (TRA2beta1 to TRA2beta5). ...However, knockdown of hnRNPA1 or hnRNPU reduced both TRA2beta1 and TRA2beta4 levels, and overexpression of these hnRNPs increased levels of both isoforms, su …
The human TRA2B gene consists of 10 exons and 9 introns and produces 5 splice isoforms (TRA2beta1 to TRA2beta5). ...However, knockdow …
Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation.
Chen G, Chen J, Qi L, Yin Y, Lin Z, Wen H, Zhang S, Xiao C, Bello SF, Zhang X, Nie Q, Luo W. Chen G, et al. Cell Prolif. 2024 Feb;57(2):e13545. doi: 10.1111/cpr.13545. Epub 2023 Sep 13. Cell Prolif. 2024. PMID: 37705195 Free PMC article.
Gene-splicing analysis demonstrated that AS acts as a regulator, independent of changes in overall gene expression. Two isoforms of splicing factor TRA2B play distinct roles in myogenic differentiation by triggering AS of TGFBR2 to regulate canonical TGF-beta signalling ca …
Gene-splicing analysis demonstrated that AS acts as a regulator, independent of changes in overall gene expression. Two isoforms of splicing …
Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B.
Zhang H, Wang J, Ren T, Huang Y, Liang X, Yu Y, Wang W, Niu J, Guo W. Zhang H, et al. Cancer Lett. 2020 Oct 10;490:54-65. doi: 10.1016/j.canlet.2020.07.008. Epub 2020 Jul 16. Cancer Lett. 2020. PMID: 32682951
In this research, we found that overexpression of transformer 2beta (TRA2B) was associated with tumor progression in osteosarcoma, and TRA2B was the target gene of miR-206, which was downregulated in osteosarcoma tissues. ...Taken together, our study demonstrates th …
In this research, we found that overexpression of transformer 2beta (TRA2B) was associated with tumor progression in osteosarcoma, an …
Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma.
Li F, Fang Z, Zhang J, Li C, Liu H, Xia J, Zhu H, Guo C, Qin Z, Li F, Han X, Wang Y, Feng Y, Wang Y, Zhang W, Wang Z, Jin Y, Sun Y, Wei W, Zeng R, Chen H, Ji H. Li F, et al. Cell Res. 2016 Oct;26(10):1149-1164. doi: 10.1038/cr.2016.111. Epub 2016 Sep 27. Cell Res. 2016. PMID: 27670699 Free PMC article.
Through mechanistic studies, we further revealed that this TRA2B-DNAH5 fusion promotes lung SCC malignant progression through regulating a SIRT6-ERK1/2-MMP1 signaling axis. We show that inhibition of ERK1/2 activation using selumetinib efficiently inhibits the growth of lu …
Through mechanistic studies, we further revealed that this TRA2B-DNAH5 fusion promotes lung SCC malignant progression through regulat …
The alternative splicing regulator Tra2b is required for somitogenesis and regulates splicing of an inhibitory Wnt11b isoform.
Dichmann DS, Walentek P, Harland RM. Dichmann DS, et al. Cell Rep. 2015 Feb 3;10(4):527-36. doi: 10.1016/j.celrep.2014.12.046. Epub 2015 Jan 22. Cell Rep. 2015. PMID: 25620705 Free PMC article.
Tra2b knockdown in Xenopus results in embryos with multiple defects, including defective somitogenesis. ...We show that this isoform acts as a dominant-negative ligand in cardiac gene induction and pronephric tubule formation. To determine the contribution of Wnt11b-short …
Tra2b knockdown in Xenopus results in embryos with multiple defects, including defective somitogenesis. ...We show that this isoform …
Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain.
Storbeck M, Hupperich K, Gaspar JA, Meganathan K, Martínez Carrera L, Wirth R, Sachinidis A, Wirth B. Storbeck M, et al. PLoS One. 2014 Feb 19;9(2):e89020. doi: 10.1371/journal.pone.0089020. eCollection 2014. PLoS One. 2014. PMID: 24586484 Free PMC article.
Here we generated a neuronal-specific Tra2b knock-out mouse that lacks Tra2b expression in neuronal and glial precursor cells by using the Nestin-Cre. Neuronal-specific Tra2b knock-out mice die immediately after birth and show severe abnormalities in cortical …
Here we generated a neuronal-specific Tra2b knock-out mouse that lacks Tra2b expression in neuronal and glial precursor cells …
142 results