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Page 1
STK35 Gene Therapy Attenuates Endothelial Dysfunction and Improves Cardiac Function in Diabetes.
Joladarashi D, Zhu Y, Willman M, Nash K, Cimini M, Thandavarayan RA, Youker KA, Song X, Ren D, Li J, Kishore R, Krishnamurthy P, Wang L. Joladarashi D, et al. Front Cardiovasc Med. 2022 Jan 13;8:798091. doi: 10.3389/fcvm.2021.798091. eCollection 2021. Front Cardiovasc Med. 2022. PMID: 35097018 Free PMC article. Retracted.
High glucose treatment, mimicking hyperglycemia in diabetes, downregulated STK35 expression in mouse cardiac endothelial cells (MCEC). Knockdown of STK35 attenuated MCEC proliferation, migration, and tube formation, whereas STK35 overexpression restored the h …
High glucose treatment, mimicking hyperglycemia in diabetes, downregulated STK35 expression in mouse cardiac endothelial cells (MCEC) …
SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
Polyanskaya SA, Moreno RY, Lu B, Feng R, Yao Y, Irani S, Klingbeil O, Yang Z, Wei Y, Demerdash OE, Benjamin LA, Weiss MJ, Zhang YJ, Vakoc CR. Polyanskaya SA, et al. Cell Rep. 2022 Jan 11;38(2):110233. doi: 10.1016/j.celrep.2021.110233. Cell Rep. 2022. PMID: 35021089 Free PMC article.
Through mass spectrometry analysis of affinity-purified complexes, we identify the kinase paralogs STK35 and PDIK1L as binding partners and substrates of the SCP4 phosphatase domain. ...We provide evidence that SCP4 regulates STK35/PDIK1L through two distinct mechan …
Through mass spectrometry analysis of affinity-purified complexes, we identify the kinase paralogs STK35 and PDIK1L as binding partne …
STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer.
Yang H, Zhu J, Wang G, Liu H, Zhou Y, Qian J. Yang H, et al. Front Cell Dev Biol. 2020 Oct 8;8:582695. doi: 10.3389/fcell.2020.582695. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33117809 Free PMC article.
Fluorouracil (5-FU) was utilized to evaluate the effect of STK35 on CRC chemoresistance. Moreover, co-immunoprecipitation was performed to explore the ubiquitination of STK35. ...Moreover, STK35 also interferes with the chemosensitivity of CRC....
Fluorouracil (5-FU) was utilized to evaluate the effect of STK35 on CRC chemoresistance. Moreover, co-immunoprecipitation was perform …
Promoter polymorphisms in STK35 and IFT27 genes and their associations with boar sperm freezability.
Mańkowska A, Brym P, Sobiech P, Fraser L. Mańkowska A, et al. Theriogenology. 2022 Sep 1;189:199-208. doi: 10.1016/j.theriogenology.2022.06.023. Epub 2022 Jun 23. Theriogenology. 2022. PMID: 35780559
Protein expression in STK35 and IFT27 was determined in pre-freeze (PF) and frozen-thawed (FT) spermatozoa, using western blotting analysis. ...STK35 and IFT27 promoter polymorphisms showed significant allele frequency differences between the GSF and PSF groups. ...
Protein expression in STK35 and IFT27 was determined in pre-freeze (PF) and frozen-thawed (FT) spermatozoa, using western blotting an …
The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress.
Miyamoto Y, Whiley PAF, Goh HY, Wong C, Higgins G, Tachibana T, McMenamin PG, Mayne L, Loveland KL. Miyamoto Y, et al. Biol Open. 2018 Aug 6;7(8):bio032631. doi: 10.1242/bio.032631. Biol Open. 2018. PMID: 29970477 Free PMC article.
Serine/threonine kinase 35 (STK35) is a recently identified human kinase with an autophosphorylation function, linked functionally to actin stress fibers, cell cycle progression and survival. STK35 has previously been shown to be highly expressed in human testis, an …
Serine/threonine kinase 35 (STK35) is a recently identified human kinase with an autophosphorylation function, linked functionally to …
Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Wu Z, Liu J, Hu S, Zhu Y, Li S. Wu Z, et al. Cell Physiol Biochem. 2018;45(2):808-818. doi: 10.1159/000487172. Epub 2018 Jan 31. Cell Physiol Biochem. 2018. PMID: 29414823 Free article.
BACKGROUND/AIMS: Serine/threonine kinase 35 (STK35) may be associated with Parkinson disease and human colorectal cancer, but there have been no reports on the expression levels or roles of STK35 in osteosarcoma. ...CONCLUSIONS: These results collectively reveal tha …
BACKGROUND/AIMS: Serine/threonine kinase 35 (STK35) may be associated with Parkinson disease and human colorectal cancer, but there h …
Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.
Goyal P, Behring A, Kumar A, Siess W. Goyal P, et al. PLoS One. 2009 Sep 16;4(9):e6981. doi: 10.1371/journal.pone.0006981. PLoS One. 2009. PMID: 19756140 Free PMC article.
METHODOLOGY/PRINCIPAL FINDINGS: In this study, we found that the previously published coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino ac …
METHODOLOGY/PRINCIPAL FINDINGS: In this study, we found that the previously published coding sequence of the STK35 gene is incomplete …
Deconvoluting Kinase Inhibitor Induced Cardiotoxicity.
Lamore SD, Ahlberg E, Boyer S, Lamb ML, Hortigon-Vinagre MP, Rodriguez V, Smith GL, Sagemark J, Carlsson L, Bates SM, Choy AL, Stålring J, Scott CW, Peters MF. Lamore SD, et al. Toxicol Sci. 2017 Jul 1;158(1):213-226. doi: 10.1093/toxsci/kfx082. Toxicol Sci. 2017. PMID: 28453775 Free PMC article.
Finally, a simple model was created to predict functional cardiotoxicity whereby inactivity at three sentinel kinases (RPS6KB1, FAK, STK35) showed exceptional accuracy in vitro and translated to clinical KI safety data. ...
Finally, a simple model was created to predict functional cardiotoxicity whereby inactivity at three sentinel kinases (RPS6KB1, FAK, STK3 …
Nuclear retention of importin α coordinates cell fate through changes in gene expression.
Yasuda Y, Miyamoto Y, Yamashiro T, Asally M, Masui A, Wong C, Loveland KL, Yoneda Y. Yasuda Y, et al. EMBO J. 2012 Jan 4;31(1):83-94. doi: 10.1038/emboj.2011.360. Epub 2011 Sep 30. EMBO J. 2012. PMID: 21964068 Free PMC article.
In this study, we found that nuclear-retained importin alpha2 binds with DNase I-sensitive nuclear component(s) and exhibits selective upregulation of mRNA encoding Serine/threonine kinase 35 (STK35) by microarray analysis. Chromatin immunoprecipitation and promoter analys …
In this study, we found that nuclear-retained importin alpha2 binds with DNase I-sensitive nuclear component(s) and exhibits selective upreg …
18 results