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Page 1
BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance.
Shu X, Li J, Chan UI, Su SM, Shi C, Zhang X, An T, Xu J, Mo L, Liu J, Wang Y, Li X, Deng M, Lei JH, Wang C, Tian H, Heng S, Shim JS, Zhang X, Dai Y, Yao Z, Kuang X, Lin Y, Deng CX, Xu X. Shu X, et al. Cancer Res. 2023 Aug 1;83(15):2614-2633. doi: 10.1158/0008-5472.CAN-22-3398. Cancer Res. 2023. PMID: 37227919 Free PMC article.
Here, we identified a mechanism mediated by sialyltransferases that induces an acidic tumor-permissive microenvironment (ATPME) in BRCA1-mutant and most BRCA1-low breast cancers. Hypersialylation mediated by ST8SIA4 perturbed the mammary epithelial bilayer structure and ge …
Here, we identified a mechanism mediated by sialyltransferases that induces an acidic tumor-permissive microenvironment (ATPME) in BRCA1-mut …
lncRNA MALAT1/miR-26a/26b/ST8SIA4 axis mediates cell invasion and migration in breast cancer cell lines.
Wang N, Cao S, Wang X, Zhang L, Yuan H, Ma X. Wang N, et al. Oncol Rep. 2021 Aug;46(2):181. doi: 10.3892/or.2021.8132. Epub 2021 Jul 19. Oncol Rep. 2021. PMID: 34278507 Free PMC article.
Moreover, miR-26a/26b was confirmed as a direct regulator of MALAT1, and ST8SIA4 was predicted as a target of miR-26a/26b. Functional analysis in human breast cancer cell lines demonstrated that MALAT1 modulated breast cancer cell tumorigenicity by acting as a competing en …
Moreover, miR-26a/26b was confirmed as a direct regulator of MALAT1, and ST8SIA4 was predicted as a target of miR-26a/26b. Functional …
Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.
Ma X, Dong W, Su Z, Zhao L, Miao Y, Li N, Zhou H, Jia L. Ma X, et al. Cell Death Dis. 2016 Dec 29;7(12):e2561. doi: 10.1038/cddis.2016.427. Cell Death Dis. 2016. PMID: 28032858 Free PMC article.
By applying bioinformatic approaches for the prediction of miRNA targeting 3'-UTR of ST8SIA4, we identified ST8SIA4 as one of the miR-26a/26b-targeted genes. ...The ability of miR-26a/26b to interact specifically with and regulate the 3'-UTR of ST8SIA4 was de …
By applying bioinformatic approaches for the prediction of miRNA targeting 3'-UTR of ST8SIA4, we identified ST8SIA4 as one of …
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Zhao L, Li Y, Song X, Zhou H, Li N, Miao Y, Jia L. Zhao L, et al. Oncotarget. 2016 Sep 13;7(37):60074-60086. doi: 10.18632/oncotarget.11054. Oncotarget. 2016. PMID: 27527856 Free PMC article.
Reporter-gene assay showed that miR-181c directly targeted and inhibited the ST8SIA4 expression, as well as miR-181c was inversely correlated with the levels of ST8SIA4 expression in CML cell lines and samples. Moreover, ST8SIA4 could reverse the effect of mi …
Reporter-gene assay showed that miR-181c directly targeted and inhibited the ST8SIA4 expression, as well as miR-181c was inversely co …
miR-144-5p and miR-451a Inhibit the Growth of Cholangiocarcinoma Cells Through Decreasing the Expression of ST8SIA4.
Fu W, Yu G, Liang J, Fan P, Dong K, Zhang B, Chen X, Zhu H, Chu L. Fu W, et al. Front Oncol. 2021 Jan 14;10:563486. doi: 10.3389/fonc.2020.563486. eCollection 2020. Front Oncol. 2021. PMID: 33520692 Free PMC article.
Knockdown of these two miRNAs had the opposite effects. miR-144-5p and miR-451a regulated the expression of ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4), and presented a correlation with ST8SIA4 in patient samples. ...Our findings indicated …
Knockdown of these two miRNAs had the opposite effects. miR-144-5p and miR-451a regulated the expression of ST8 alpha-N-acetyl-neuraminide a …
TEP linc-GTF2H2-1, RP3-466P17.2, and lnc-ST8SIA4-12 as novel biomarkers for lung cancer diagnosis and progression prediction.
Li X, Liu L, Song X, Wang K, Niu L, Xie L, Song X. Li X, et al. J Cancer Res Clin Oncol. 2021 Jun;147(6):1609-1622. doi: 10.1007/s00432-020-03502-5. Epub 2021 Jan 29. J Cancer Res Clin Oncol. 2021. PMID: 33792796
METHODS: Platelet precipitation was obtained by low-speed centrifugation. TEP linc-GTF2H2-1, RP3-466P17.2, and lnc-ST8SIA4-12 were selected by lncRNA microarray and validated by qPCR in a large cohort of lung cancer patients and healthy donors. ...RESULTS: TEP linc-GTF2H2- …
METHODS: Platelet precipitation was obtained by low-speed centrifugation. TEP linc-GTF2H2-1, RP3-466P17.2, and lnc-ST8SIA4-12 were se …
Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.
Mori A, Hane M, Niimi Y, Kitajima K, Sato C. Mori A, et al. Glycobiology. 2017 Sep 1;27(9):834-846. doi: 10.1093/glycob/cwx057. Glycobiology. 2017. PMID: 28810663
In this study, to clarify this point, we first prepared polySia-NCAMs from HEK293 cells stably expressing ST8SIA4 and ST8SIA2, or ST8SIA2 (SNP-7), a mutant ST8SIA2 derived from a schizophrenia patient. The conventional sensitive chemical and immunological characterizations …
In this study, to clarify this point, we first prepared polySia-NCAMs from HEK293 cells stably expressing ST8SIA4 and ST8SIA2, or ST8 …
miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
Ma W, Zhao X, Liang L, Wang G, Li Y, Miao X, Zhao Y. Ma W, et al. Oncotarget. 2017 Apr 25;8(17):28028-28041. doi: 10.18632/oncotarget.15885. Oncotarget. 2017. PMID: 28427206 Free PMC article.
Additionally, ST8SIA4 inhibited proliferation, migration and invasion of FTC both in vitro and in vivo. miR-146a and miR-146b were previously shown to be upregulated in thyroid carcinoma, and bioinformatics analyses indicated that miR-146a and miR-146b inhibit ST8SIA4 …
Additionally, ST8SIA4 inhibited proliferation, migration and invasion of FTC both in vitro and in vivo. miR-146a and miR-146b were pr …
Assay for enzymatic activity of polysialyltransferase.
Hane M, Sato C. Hane M, et al. 2021 Nov 1 [updated 2022 Apr 27]. In: Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, editors. Glycoscience Protocols (GlycoPODv2) [Internet]. Saitama (JP): Japan Consortium for Glycobiology and Glycotechnology; 2021–. 2021 Nov 1 [updated 2022 Apr 27]. In: Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, editors. Glycoscience Protocols (GlycoPODv2) [Internet]. Saitama (JP): Japan Consortium for Glycobiology and Glycotechnology; 2021–. PMID: 37590584 Free Books & Documents. Review. No abstract available.
83 results