SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
Carracedo S, Lirussi L, Alsøe L, Segers F, Wang C, Bartosova Z, Bohov P, Tekin NB, Kong XY, Esbensen QY, Chen L, Wennerström A, Kroustallaki P, Ceolotto D, Tönjes A, Berge RK, Bruheim P, Wong G, Böttcher Y, Halvorsen B, Nilsen H.
Carracedo S, et al.
DNA Repair (Amst). 2022 Dec;120:103410. doi: 10.1016/j.dnarep.2022.103410. Epub 2022 Oct 3.
DNA Repair (Amst). 2022.
PMID: 36244177
Recently, a correlation between the base excision repair enzyme SMUG1 and metabolic homeostasis was identified. As the molecular mechanisms remain unknown, we exploited a SMUG1-knockout mouse model to gain insights into this association by characterizing the liver p …
Recently, a correlation between the base excision repair enzyme SMUG1 and metabolic homeostasis was identified. As the molecular mech …