Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 3
2002 4
2003 7
2004 4
2005 4
2006 4
2007 7
2008 6
2009 10
2010 2
2011 5
2012 8
2013 11
2014 12
2015 4
2016 8
2017 13
2018 5
2019 10
2020 5
2021 12
2022 13
2023 11
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

156 results

Results by year

Filters applied: . Clear all
Page 1
The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer.
Raja S, Van Houten B. Raja S, et al. Int J Mol Sci. 2021 Feb 17;22(4):1981. doi: 10.3390/ijms22041981. Int J Mol Sci. 2021. PMID: 33671338 Free PMC article. Review.
Rodent studies suggest that, while SMUG1 shares substrate specificity with another uracil glycosylase UNG2, loss of SMUG1 can have unique cellular phenotypes. This review highlights the multiple roles SMUG1 may play in preserving genome stability, and how the …
Rodent studies suggest that, while SMUG1 shares substrate specificity with another uracil glycosylase UNG2, loss of SMUG1 can …
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
Carracedo S, Lirussi L, Alsøe L, Segers F, Wang C, Bartosova Z, Bohov P, Tekin NB, Kong XY, Esbensen QY, Chen L, Wennerström A, Kroustallaki P, Ceolotto D, Tönjes A, Berge RK, Bruheim P, Wong G, Böttcher Y, Halvorsen B, Nilsen H. Carracedo S, et al. DNA Repair (Amst). 2022 Dec;120:103410. doi: 10.1016/j.dnarep.2022.103410. Epub 2022 Oct 3. DNA Repair (Amst). 2022. PMID: 36244177
Recently, a correlation between the base excision repair enzyme SMUG1 and metabolic homeostasis was identified. As the molecular mechanisms remain unknown, we exploited a SMUG1-knockout mouse model to gain insights into this association by characterizing the liver p …
Recently, a correlation between the base excision repair enzyme SMUG1 and metabolic homeostasis was identified. As the molecular mech …
SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing.
Kroustallaki P, Lirussi L, Carracedo S, You P, Esbensen QY, Götz A, Jobert L, Alsøe L, Sætrom P, Gagos S, Nilsen H. Kroustallaki P, et al. Cell Rep. 2019 Aug 13;28(7):1690-1702.e10. doi: 10.1016/j.celrep.2019.07.040. Cell Rep. 2019. PMID: 31412240 Free article.
We demonstrate that SMUG1 regulates the presence of base modifications in hTERC, in a region between the CR4/CR5 domain and the H box. ...Consequently, SMUG1-deprived cells exhibit telomerase deficiency, leading to impaired bone marrow proliferation in Smug1- …
We demonstrate that SMUG1 regulates the presence of base modifications in hTERC, in a region between the CR4/CR5 domain and the H box …
UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties.
Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. Jang S, et al. Nucleic Acids Res. 2023 Jun 9;51(10):4881-4898. doi: 10.1093/nar/gkad206. Nucleic Acids Res. 2023. PMID: 36971122 Free PMC article.
Electrophoretic mobility shift assays indicated that UV-DDB displaced SMUG1 from abasic site products. Single-molecule analysis revealed that UV-DDB decreases the half-life of SMUG1 on DNA by 8-fold. Immunofluorescence experiments demonstrated that cellular treatmen …
Electrophoretic mobility shift assays indicated that UV-DDB displaced SMUG1 from abasic site products. Single-molecule analysis revea …
RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control.
Lirussi L, Demir Ö, You P, Sarno A, Amaro RE, Nilsen H. Lirussi L, et al. Biomolecules. 2021 Jan 8;11(1):76. doi: 10.3390/biom11010076. Biomolecules. 2021. PMID: 33430019 Free PMC article. Review.
Here, we review rRNA modifications and RNA quality control mechanisms in general and discuss the specific function of SMUG1 in rRNA metabolism. Cells lacking SMUG1 have elevated levels of immature rRNA molecules and accumulation of 5-hydroxymethyluridine (5hmU) in m …
Here, we review rRNA modifications and RNA quality control mechanisms in general and discuss the specific function of SMUG1 in rRNA m …
Ablation of SMUG1 Reduces Cell Viability and Increases UVC-Mediated Apoptosis in Hepatocarcinoma HepG2 Cells.
An MJ, Shin GS, Lee HM, Kim JW. An MJ, et al. Genes (Basel). 2021 Jan 30;12(2):201. doi: 10.3390/genes12020201. Genes (Basel). 2021. PMID: 33573186 Free PMC article.
Moreover, the apoptotic cells by DNA damage accumulation were markedly increased in SMUG1 KD and KO cells after ultraviolet C irradiation. Transcriptomic analysis using RNA-seq revealed that SMUG1 was involved in gene sets expression including cell cycle transition …
Moreover, the apoptotic cells by DNA damage accumulation were markedly increased in SMUG1 KD and KO cells after ultraviolet C irradia …
Ionic strength modulates excision of uracil by SMUG1 from nucleosome core particles.
Rioux KL, Delaney S. Rioux KL, et al. DNA Repair (Amst). 2023 May;125:103482. doi: 10.1016/j.dnarep.2023.103482. Epub 2023 Mar 12. DNA Repair (Amst). 2023. PMID: 36931160 Free PMC article.
Using a population of NCPs containing uracil (U) at dozens of geometric locations, excision of U by single-strand selective monofunctional uracil DNA glycosylase (SMUG1) is assessed at higher and lower ionic strengths. SMUG1 has increased excision activity in the lo …
Using a population of NCPs containing uracil (U) at dozens of geometric locations, excision of U by single-strand selective monofunctional u …
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.
Fugger K, Bajrami I, Silva Dos Santos M, Young SJ, Kunzelmann S, Kelly G, Hewitt G, Patel H, Goldstone R, Carell T, Boulton SJ, MacRae J, Taylor IA, West SC. Fugger K, et al. Science. 2021 Apr 9;372(6538):156-165. doi: 10.1126/science.abb4542. Science. 2021. PMID: 33833118 Free PMC article.
We show that inhibition of DNPH1, a protein that eliminates cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine (hmdU) monophosphate, potentiates the sensitivity of BRCA-deficient cells to PARP inhibitors (PARPi). Synthetic lethality was mediated by the action of SMUG1 glyco …
We show that inhibition of DNPH1, a protein that eliminates cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine (hmdU) monophosphate, potentia …
A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours.
Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H. Lirussi L, et al. Nucleic Acids Res. 2022 Oct 14;50(18):10449-10468. doi: 10.1093/nar/gkac807. Nucleic Acids Res. 2022. PMID: 36156150 Free PMC article.
Based on this, we hypothesized that the dominating function of SMUG1 in cancer might be ascribed to functions other than BER. We define a bad prognosis signature for SMUG1 by mapping out the SMUG1 interaction network and found that high expression of genes in …
Based on this, we hypothesized that the dominating function of SMUG1 in cancer might be ascribed to functions other than BER. We defi …
SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.
Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD. Nagaria P, et al. Mutat Res. 2013 Mar-Apr;743-744:26-32. doi: 10.1016/j.mrfmmm.2012.12.001. Epub 2012 Dec 17. Mutat Res. 2013. PMID: 23253900 Free PMC article.
There was no difference between SMUG1 proficient and depleted cells following continuous exposure. ...Collectively, the results suggest that SMUG1 has a role in the resumption of replication following 5-FU treatment....
There was no difference between SMUG1 proficient and depleted cells following continuous exposure. ...Collectively, the results sugge …
156 results