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2007 1
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27 results

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Slfn4 deficiency improves MAPK-mediated inflammation, oxidative stress, apoptosis and abates atherosclerosis progression in apolipoprotein E-deficient mice.
Zheng Q, Duan L, Lou Y, Chao T, Guo G, Lu L, Zhang H, Zhao Y, Liang Y, Wang H. Zheng Q, et al. Atherosclerosis. 2021 Oct 16;337:42-52. doi: 10.1016/j.atherosclerosis.2021.10.010. Online ahead of print. Atherosclerosis. 2021. PMID: 34757313
Nonetheless, the role of Slfn4 in foam cell formation remains unclear. METHODS: To determine whether and how Slfn4 regulates lesion macrophage function during atherosclerosis,we engineered ApoE(-/-)Slfn4(-/-) double-deficient mice on an ApoE(-/-) background a …
Nonetheless, the role of Slfn4 in foam cell formation remains unclear. METHODS: To determine whether and how Slfn4 regulates l …
Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases.
Ding L, Sheriff S, Sontz RA, Merchant JL. Ding L, et al. Front Immunol. 2023 Jun 2;14:1139391. doi: 10.3389/fimmu.2023.1139391. eCollection 2023. Front Immunol. 2023. PMID: 37334372 Free PMC article.
Knockdown of Slfn4 by siRNA or PDE5/6 inhibition by sildenafil were performed in vitro. ...Knocking down Slfn4 or PDE5/6 inhibition with sildenafil blocked IFNa induction of GTP, SLFN4 and NOS2. ...
Knockdown of Slfn4 by siRNA or PDE5/6 inhibition by sildenafil were performed in vitro. ...Knocking down Slfn4 or PDE5/6 inhib …
Toll-like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-induced Gastric Metaplasias.
Ding L, Chakrabarti J, Sheriff S, Li Q, Thi Hong HN, Sontz RA, Mendoza ZE, Schreibeis A, Helmrath MA, Zavros Y, Merchant JL. Ding L, et al. Gastroenterology. 2022 Aug;163(2):411-425.e4. doi: 10.1053/j.gastro.2022.04.031. Epub 2022 Apr 26. Gastroenterology. 2022. PMID: 35487288 Free PMC article.
BACKGROUND & AIMS: A subset of myeloid-derived suppressor cells (MDSCs) that express murine Schlafen4 (SLFN4) or its human ortholog SLFN12L polarize in the Helicobacter-inflamed stomach coincident with intestinal or spasmolytic polypeptide-expressing metaplasia. ...
BACKGROUND & AIMS: A subset of myeloid-derived suppressor cells (MDSCs) that express murine Schlafen4 (SLFN4) or its human orthol …
C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape.
Guo Y, Zhao C, Dai W, Wang B, Lai E, Xiao Y, Tang C, Huang Z, Gao J. Guo Y, et al. Int J Biol Sci. 2023 May 8;19(8):2572-2587. doi: 10.7150/ijbs.83530. eCollection 2023. Int J Biol Sci. 2023. PMID: 37215993 Free PMC article.
In vitro, CVC could transcriptionally suppress crucial profibrotic genes (Xaf1, Slfn4, Slfn8, Ifi213, and Il1beta) in macrophages by inactivating the STAT1/NFkappaB/ERK signaling pathways. ...
In vitro, CVC could transcriptionally suppress crucial profibrotic genes (Xaf1, Slfn4, Slfn8, Ifi213, and Il1beta) in macrophages by …
Plasmacytoid Dendritic Cell-Derived Type I Interferon Is Involved in Helicobacter pylori Infection-Induced Differentiation of Schlafen 4-Expressing Myeloid-Derived Suppressor Cells.
Xiang X, Wu Y, Li H, Li C, Yan L, Li Q. Xiang X, et al. Infect Immun. 2021 Oct 15;89(11):e0040721. doi: 10.1128/IAI.00407-21. Epub 2021 Aug 2. Infect Immun. 2021. PMID: 34370509 Free PMC article.
SLFN4 can be induced by alpha interferon (IFN-alpha), which is mainly secreted from plasmacytoid dendritic cells (pDCs). ...The results showed that H. pylori infection increased the number of SLFN4(+) MDSCs by inducing IFN-alpha expression in mice. Further mechanist …
SLFN4 can be induced by alpha interferon (IFN-alpha), which is mainly secreted from plasmacytoid dendritic cells (pDCs). ...The resul …
MiR130b from Schlafen4+ MDSCs stimulates epithelial proliferation and correlates with preneoplastic changes prior to gastric cancer.
Ding L, Li Q, Chakrabarti J, Munoz A, Faure-Kumar E, Ocadiz-Ruiz R, Razumilava N, Zhang G, Hayes MH, Sontz RA, Mendoza ZE, Mahurkar S, Greenson JK, Perez-Perez G, Hanh NTH, Zavros Y, Samuelson LC, Iliopoulos D, Merchant JL. Ding L, et al. Gut. 2020 Oct;69(10):1750-1761. doi: 10.1136/gutjnl-2019-318817. Epub 2020 Jan 24. Gut. 2020. PMID: 31980446 Free PMC article.
OBJECTIVE: To identify the gene products expressed by Slfn4(+)-MDSCs and to determine how they promote SPEM. DESIGN: We performed transcriptome analyses for both coding genes (mRNA by RNA-Seq) and non-coding genes (microRNAs using NanoString nCounter) using flow-sorted …
OBJECTIVE: To identify the gene products expressed by Slfn4(+)-MDSCs and to determine how they promote SPEM. DESIGN: We performed tra …
Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia.
Ding L, Hayes MM, Photenhauer A, Eaton KA, Li Q, Ocadiz-Ruiz R, Merchant JL. Ding L, et al. J Clin Invest. 2016 Aug 1;126(8):2867-80. doi: 10.1172/JCI82529. Epub 2016 Jul 18. J Clin Invest. 2016. PMID: 27427984 Free PMC article.
Lineage tracing in Helicobacter-infected Slfn4 reporter mice revealed that SLFN4+ cells migrated to the stomach, where they exhibited myeloid-derived suppressor cell (MDSC) markers and acquired the ability to inhibit T cell proliferation. SLFN4+ MDSCs were no …
Lineage tracing in Helicobacter-infected Slfn4 reporter mice revealed that SLFN4+ cells migrated to the stomach, where they ex …
Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions.
Merchant JL, Ding L. Merchant JL, et al. Cell Mol Gastroenterol Hepatol. 2017 Jan 16;3(2):201-210. doi: 10.1016/j.jcmgh.2017.01.004. eCollection 2017 Mar. Cell Mol Gastroenterol Hepatol. 2017. PMID: 28275687 Free PMC article. Review.
In mice, GLI1 mediates the phenotypic shift to gastric myeloid-derived suppressor cells by directly inducing Schlafen 4 (slfn4). However, the human homologs of SLFN4, designated SLFN5 and SLFN12L, also correlate with intestinal metaplasia and could be used as biomar …
In mice, GLI1 mediates the phenotypic shift to gastric myeloid-derived suppressor cells by directly inducing Schlafen 4 (slfn4). Howe …
The Cxcr2+ subset of the S100a8+ gastric granylocytic myeloid-derived suppressor cell population (G-MDSC) regulates gastric pathology.
Kao KD, Grasberger H, El-Zaatari M. Kao KD, et al. Front Immunol. 2023 Sep 8;14:1147695. doi: 10.3389/fimmu.2023.1147695. eCollection 2023. Front Immunol. 2023. PMID: 37744359 Free PMC article.
RESULTS: Following 6-months of Helicobacter felis infection, gastric CD11b(+)Ly6G(+) G-MDSCs were highly enriched for the expression of S100a8, S100a9, Slfn4, Cxcr2, Irg1, Il1f9, Hcar2, Retnlg, Wfdc21, Trem1, Csf3R, Nlrp3, and Il1b. ...
RESULTS: Following 6-months of Helicobacter felis infection, gastric CD11b(+)Ly6G(+) G-MDSCs were highly enriched for the expression of S100 …
Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis.
van Zuylen WJ, Garceau V, Idris A, Schroder K, Irvine KM, Lattin JE, Ovchinnikov DA, Perkins AC, Cook AD, Hamilton JA, Hertzog PJ, Stacey KJ, Kellie S, Hume DA, Sweet MJ. van Zuylen WJ, et al. PLoS One. 2011 Jan 7;6(1):e15723. doi: 10.1371/journal.pone.0015723. PLoS One. 2011. PMID: 21249125 Free PMC article.
CONCLUSIONS: Slfn4 mRNA levels were up-regulated during macrophage activation but down-regulated during differentiation. Constitutive Slfn4 expression in the myeloid lineage in vivo perturbs myelopoiesis. ...
CONCLUSIONS: Slfn4 mRNA levels were up-regulated during macrophage activation but down-regulated during differentiation. Constitutive …
27 results