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SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity.
Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B. Yue T, et al. Science. 2021 May 14;372(6543):eaba4220. doi: 10.1126/science.aba4220. Science. 2021. PMID: 33986151 Free PMC article.
T cell-specific SLFN2 deficiency results in the accumulation of tRNA fragments, which inhibit translation and promote stress-granule formation. Interleukin-2 receptor beta (IL-2Rbeta) and IL-2Rgamma fail to be translationally up-regulated after T cell receptor stimulation, …
T cell-specific SLFN2 deficiency results in the accumulation of tRNA fragments, which inhibit translation and promote stress-granule …
Quieting T cells with Slfn2.
Horton MR, Powell JD. Horton MR, et al. Nat Immunol. 2010 Apr;11(4):281-2. doi: 10.1038/ni0410-281. Nat Immunol. 2010. PMID: 20300134 Free PMC article. Review.
The mechanisms that enforce T cell quiescence are incompletely understood. Slfn2 has now been identified as another participant in this process, functioning as a critical regulator of T cell- and monocyte-mediated immunity....
The mechanisms that enforce T cell quiescence are incompletely understood. Slfn2 has now been identified as another participant in th …
Slfn2 Regulates Type I Interferon Responses by Modulating the NF-kappaB Pathway.
Fischietti M, Arslan AD, Sassano A, Saleiro D, Majchrzak-Kita B, Ebine K, Munshi HG, Fish EN, Platanias LC. Fischietti M, et al. Mol Cell Biol. 2018 Jul 30;38(16):e00053-18. doi: 10.1128/MCB.00053-18. Print 2018 Aug 15. Mol Cell Biol. 2018. PMID: 29866656 Free PMC article.
In the present study, we provide evidence that targeted disruption of the Slfn2 gene leads to increased transcription of IFN-stimulated genes (ISGs) and enhanced type I IFN-mediated antiviral responses. ...Altogether, these data suggest a novel mechanism by which Slfn2 …
In the present study, we provide evidence that targeted disruption of the Slfn2 gene leads to increased transcription of IFN-stimulat …
Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.
Omar I, Rom O, Aviram M, Cohen-Daniel L, Gebre AK, Parks JS, Berger M. Omar I, et al. Immunology. 2017 Nov;152(3):484-493. doi: 10.1111/imm.12785. Epub 2017 Aug 2. Immunology. 2017. PMID: 28672048 Free PMC article.
Recently we demonstrated that by preventing chronic unresolved endoplasmic reticulum (ER) stress, Schlafen2 (Slfn2) maintains a stress-free environment to conserve a pool of naive T cells ready to respond to a microbial invasion. ...Here we demonstrate that homeostasis of …
Recently we demonstrated that by preventing chronic unresolved endoplasmic reticulum (ER) stress, Schlafen2 (Slfn2) maintains a stres …
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y, Khovananth K, Moresco EM, Satoh T, Takeuchi O, Akira S, Beutler B. Berger M, et al. Nat Immunol. 2010 Apr;11(4):335-43. doi: 10.1038/ni.1847. Epub 2010 Feb 28. Nat Immunol. 2010. PMID: 20190759 Free PMC article.
We positionally ascribe the elektra phenotype to a mutation in the gene encoding Schlafen-2 (Slfn2). Our findings identify a physiological role for Slfn2 in the defense against pathogens through the regulation of quiescence in T cells and monocytes....
We positionally ascribe the elektra phenotype to a mutation in the gene encoding Schlafen-2 (Slfn2). Our findings identify a physiolo …
Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells.
Warsi S, Dahl M, Smith EMK, Rydstrom A, Mansell E, Sigurdsson V, Sjoberg J, Soneji S, Rorby E, Siva K, Grahn THM, Liu Y, Blank U, Karlsson G, Karlsson S. Warsi S, et al. Haematologica. 2022 Dec 1;107(12):2884-2896. doi: 10.3324/haematol.2021.279799. Haematologica. 2022. PMID: 35615926 Free PMC article.
Interestingly, Slfn2 is highly expressed in primitive hematopoietic cells. In order to investigate the role of Slfn2 in the regulation of HSC we have studied HSC function in the elektra mouse model, where the elektra allele of the Slfn2 gene contains a point …
Interestingly, Slfn2 is highly expressed in primitive hematopoietic cells. In order to investigate the role of Slfn2 in the re …
Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL.
Goldshtein A, Zerbib SM, Omar I, Cohen-Daniel L, Popkin D, Berger M. Goldshtein A, et al. Oncotarget. 2016 Jul 26;7(30):46835-46847. doi: 10.18632/oncotarget.9390. Oncotarget. 2016. PMID: 27206675 Free PMC article.
Our study suggest that in certain malignancies, such as T-ALL, a novel therapeutic strategy may be applied by imposing aberrant development of leukemic cells. Furthermore, as the elektra mutation in Slfn2 seems to impair only T-cells and monocytes, targeting Slfn2 i …
Our study suggest that in certain malignancies, such as T-ALL, a novel therapeutic strategy may be applied by imposing aberrant development …
Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses.
Katsoulidis E, Carayol N, Woodard J, Konieczna I, Majchrzak-Kita B, Jordan A, Sassano A, Eklund EA, Fish EN, Platanias LC. Katsoulidis E, et al. J Biol Chem. 2009 Sep 11;284(37):25051-64. doi: 10.1074/jbc.M109.030445. Epub 2009 Jul 10. J Biol Chem. 2009. PMID: 19592487 Free PMC article.
We also provide evidence for a key functional role of a member of the SLFN family, SLFN2, in the induction of the growth-suppressive effects of IFNs. ...Importantly, NIH3T3 or L929 cells with stable knockdown of SLFN2 form more colonies in soft agar, implicating thi …
We also provide evidence for a key functional role of a member of the SLFN family, SLFN2, in the induction of the growth-suppressive …
Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors.
Omar I, Guterman-Ram G, Rahat D, Tabach Y, Berger M, Levaot N. Omar I, et al. Sci Rep. 2018 Aug 29;8(1):13005. doi: 10.1038/s41598-018-31428-z. Sci Rep. 2018. PMID: 30158544 Free PMC article.
Slfn2(eka/eka) mice exhibited a profound increase in their cancellous bone mass and a significant reduction in osteoclast numbers. ...Finally, we show that the bone marrow of Slfn2(eka/eka) mice have significantly less CD11b(-)Ly6C(hi) osteoclast precursors. ...
Slfn2(eka/eka) mice exhibited a profound increase in their cancellous bone mass and a significant reduction in osteoclast numbers. .. …
Effect of Schlafen 2 on natural killer and T cell development from common T/natural killer progenitors.
Ahmadi S, Veinotte LL. Ahmadi S, et al. Pak J Biol Sci. 2011 Nov 15;14(22):1002-10. doi: 10.3923/pjbs.2011.1002.1010. Pak J Biol Sci. 2011. PMID: 22514877
Maturation of both NK and T cells from immature T/NK thymocytes hampered by Slfn1 and Slfn2 transduction but we got a small number of Slfn1 and Slfn2 expressing cells upon culture of transduced DN progenitors on stroma cells. ...Based on our findings both Slfn1 and …
Maturation of both NK and T cells from immature T/NK thymocytes hampered by Slfn1 and Slfn2 transduction but we got a small number of …
19 results