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SLC9B1 methylation predicts fetal intolerance of labor.
Knight AK, Conneely KN, Kilaru V, Cobb D, Payne JL, Meilman S, Corwin EJ, Kaminsky ZA, Dunlop AL, Smith AK. Knight AK, et al. Epigenetics. 2018;13(1):33-39. doi: 10.1080/15592294.2017.1411444. Epub 2018 Jan 25. Epigenetics. 2018. PMID: 29235940 Free PMC article.
DNA methylation patterns at CpG sites across the genome were interrogated for associations with fetal intolerance of labor. Four CpG sites (P value <8.9 10(-9), FDR <0.05) in gene SLC9B1, a Na(+)/H(+) exchanger, were associated with fetal intolerance of labor. ...Fet …
DNA methylation patterns at CpG sites across the genome were interrogated for associations with fetal intolerance of labor. Four CpG sites ( …
Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene.
Holmes RS, Spradling-Reeves KD, Cox LA. Holmes RS, et al. J Phylogenetics Evol Biol. 2016 Aug;4(3):167. doi: 10.4172/2329-9002.1000167. Epub 2016 Jun 10. J Phylogenetics Evol Biol. 2016. PMID: 28868326 Free PMC article.
Mammalian SLC9B2 and SLC9B1 genes usually contained 11 or 12 coding exons with differential tissue expression patterns: SLC9B2, broad tissue distribution; and SLC9B1, being testis specific. Transcription factor binding sites and CpG islands within the human SLC9B2 a …
Mammalian SLC9B2 and SLC9B1 genes usually contained 11 or 12 coding exons with differential tissue expression patterns: SLC9B2, broad …
Shared genetics and causal relationships between migraine and thyroid function traits.
Tasnim S, Wilson SG, Walsh JP, Nyholt DR; International Headache Genetics Consortium (IHGC). Tasnim S, et al. Cephalalgia. 2023 Feb;43(2):3331024221139253. doi: 10.1177/03331024221139253. Cephalalgia. 2023. PMID: 36739509 Free article.
Cross-trait GWAS meta-analysis of migraine identified novel genome-wide significant loci: 17 with hypothyroidism, one with hyperthyroidism, five with secondary hypothyroidism, eight with TSH, and 15 with fT4. Of the genes at these loci, six (RERE, TGFB2, APLF, SLC9B1, SGTB …
Cross-trait GWAS meta-analysis of migraine identified novel genome-wide significant loci: 17 with hypothyroidism, one with hyperthyroidism, …
Identification and characterization of methylation-dependent/independent DNA regulatory elements in the human SLC9B1 gene.
Kumar PL, James PF. Kumar PL, et al. Gene. 2015 May 1;561(2):235-48. doi: 10.1016/j.gene.2015.02.050. Epub 2015 Feb 19. Gene. 2015. PMID: 25701605 Free PMC article.
In this study we have identified multiple DNA regulatory elements in the 5' end of the gene encoding hNHEDC1 (SLC9B1) and have explored the role that DNA methylation at these elements plays in the regulation of its expression. ...Finally, we have uncovered both enhancer an …
In this study we have identified multiple DNA regulatory elements in the 5' end of the gene encoding hNHEDC1 (SLC9B1) and have explor …
Traditional and emerging roles for the SLC9 Na+/H+ exchangers.
Fuster DG, Alexander RT. Fuster DG, et al. Pflugers Arch. 2014 Jan;466(1):61-76. doi: 10.1007/s00424-013-1408-8. Epub 2013 Dec 12. Pflugers Arch. 2014. PMID: 24337822 Free article. Review.
The SLC9B subgroup consists of two recently cloned isoforms, NHA1 and NHA2 (SLC9B1 and SLC9B2, respectively). The SLC9C subgroup consist of a sperm specific plasmalemmal NHE (SLC9C1) and a putative NHE, SLC9C2, for which there is currently no functional data [46]. ...
The SLC9B subgroup consists of two recently cloned isoforms, NHA1 and NHA2 (SLC9B1 and SLC9B2, respectively). The SLC9C subgroup cons …
The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily-Structure, Function, Regulation and Potential Drug-Target Approaches.
Anderegg MA, Gyimesi G, Ho TM, Hediger MA, Fuster DG. Anderegg MA, et al. Front Physiol. 2022 May 25;13:898508. doi: 10.3389/fphys.2022.898508. eCollection 2022. Front Physiol. 2022. PMID: 35694410 Free PMC article. Review.
In addition, NHA2 has been proposed to contribute to the pathogenesis of polycystic kidney disease, the most common inherited kidney disease in humans. NHA1 (also known as SLC9B1) is mainly expressed in testis and is important for sperm motility and thus male fertility, bu …
In addition, NHA2 has been proposed to contribute to the pathogenesis of polycystic kidney disease, the most common inherited kidney disease …
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools.
Bahrami S, Hindley G, Winsvold BS, O'Connell KS, Frei O, Shadrin A, Cheng W, Bettella F, Rødevand L, Odegaard KJ, Fan CC, Pirinen MJ, Hautakangas HM; HUNT All-In Headache; Dale AM, Djurovic S, Smeland OB, Andreassen OA. Bahrami S, et al. Brain. 2022 Mar 29;145(1):142-153. doi: 10.1093/brain/awab267. Brain. 2022. PMID: 34273149 Free PMC article.
Functional annotation mapped 37 and 298 genes to migraine and each of depression and schizophrenia, respectively, including several novel putative migraine genes such as L3MBTL2, CACNB2 and SLC9B1. Gene-set analysis identified several putative gene sets enriched with mappe …
Functional annotation mapped 37 and 298 genes to migraine and each of depression and schizophrenia, respectively, including several novel pu …
Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar.
Haris B, Ahmed I, Syed N, Almabrazi H, Saraswathi S, Al-Khawaga S, Saeed A, Mundekkadan S, Mohammed I, Sharari S, Hawari I, Hamed N, Afyouni H, Abdel-Karim T, Mohammed S, Khalifa A, Al-Maadheed M, Zyoud M, Shamekh A, Elawwa A, Karim MY, Al-Khalaf F, Tatari-Calderone Z, Petrovski G, Hussain K. Haris B, et al. Sci Rep. 2021 Sep 23;11(1):18887. doi: 10.1038/s41598-021-98460-4. Sci Rep. 2021. PMID: 34556755 Free PMC article.
GADA was the most common autoantibody followed by IAA. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, p value = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. ...
GADA was the most common autoantibody followed by IAA. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of …
Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities.
Chintapalli VR, Kato A, Henderson L, Hirata T, Woods DJ, Overend G, Davies SA, Romero MF, Dow JA. Chintapalli VR, et al. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11720-5. doi: 10.1073/pnas.1508031112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324901 Free PMC article.
In Drosophila, as in humans, they are represented by two genes, Nha1 (Slc9b1) and Nha2 (Slc9b2), which are enriched and functionally significant in renal tubules. ...
In Drosophila, as in humans, they are represented by two genes, Nha1 (Slc9b1) and Nha2 (Slc9b2), which are enriched and functionally …
Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.
Schaschl H, Wallner B. Schaschl H, et al. BMC Evol Biol. 2020 Feb 13;20(1):27. doi: 10.1186/s12862-019-1575-0. BMC Evol Biol. 2020. PMID: 32054438 Free PMC article.
At the same time, we found evidence for recent positive directional selection acting on several human testis-enriched genes (MORC1, SLC9B1, ROPN1L, DMRT1, PLCZ1, RNF17, FAM71D and WBP2NL) that play important roles in human spermatogenesis and fertilization. ...
At the same time, we found evidence for recent positive directional selection acting on several human testis-enriched genes (MORC1, SLC9B …
11 results