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Year Number of Results
1998 1
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2005 4
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2007 7
2008 5
2009 3
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2011 3
2012 3
2013 1
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96 results

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Page 1
SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.
Berge T, Grønningsæter IH, Lorvik KB, Abrahamsen G, Granum S, Sundvold-Gjerstad V, Corthay A, Bogen B, Spurkland A. Berge T, et al. PLoS One. 2012;7(10):e48239. doi: 10.1371/journal.pone.0048239. Epub 2012 Oct 29. PLoS One. 2012. PMID: 23144743 Free PMC article.
Young, unchallenged SH2D2A-deficient C57BL/6 mice exhibit a relatively normal immune phenotype. To address whether SH2D2A regulates physiologic immune responses, SH2D2A-deficient TCR-transgenic BALB/c mice were generated. ...
Young, unchallenged SH2D2A-deficient C57BL/6 mice exhibit a relatively normal immune phenotype. To address whether SH2D2A regu …
The SH2D2A gene and susceptibility to multiple sclerosis.
Lorentzen AR, Smestad C, Lie BA, Oturai AB, Akesson E, Saarela J, Myhr KM, Vartdal F, Celius EG, Sørensen PS, Hillert J, Spurkland A, Harbo HF. Lorentzen AR, et al. J Neuroimmunol. 2008 Jul 15;197(2):152-8. doi: 10.1016/j.jneuroim.2008.04.037. Epub 2008 Jun 12. J Neuroimmunol. 2008. PMID: 18554728
We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparag …
We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic …
Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational level.
Kolltveit KM, Granum S, Aasheim HC, Forsbring M, Sundvold-Gjerstad V, Dai KZ, Molberg O, Schjetne KW, Bogen B, Shapiro VS, Johansen FE, Schenck K, Spurkland A. Kolltveit KM, et al. Mol Immunol. 2008 Apr;45(8):2380-90. doi: 10.1016/j.molimm.2007.11.005. Epub 2007 Dec 26. Mol Immunol. 2008. PMID: 18160104
The T-cell specific adapter protein (TSAd) encoded by the SH2D2A gene is up-regulated in activated human CD4+ T-cells in a cAMP-dependent manner. Expression of SH2D2A is important for proper activation of T-cells. Here, we show that SH2D2A expression is regul …
The T-cell specific adapter protein (TSAd) encoded by the SH2D2A gene is up-regulated in activated human CD4+ T-cells in a cAMP-depen …
Polymorphism of CD1 and SH2D2A genes in inflammatory neuropathies.
Uncini A, Notturno F, Pace M, Caporale CM. Uncini A, et al. J Peripher Nerv Syst. 2011 Jun;16 Suppl 1:48-51. doi: 10.1111/j.1529-8027.2011.00307.x. J Peripher Nerv Syst. 2011. PMID: 21696499
We studied, with a gene candidate approach, the CD1 system specialized in capturing and presenting glycolipids to antigen-specific T cells, and the SH2D2A gene encoding for a T-cell-specific adapter protein implicated in control of early T-cell activation. ...Confirmation …
We studied, with a gene candidate approach, the CD1 system specialized in capturing and presenting glycolipids to antigen-specific T cells, …
The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis.
Dai KZ, Harbo HF, Celius EG, Oturai A, Sørensen PS, Ryder LP, Datta P, Svejgaard A, Hillert J, Fredrikson S, Sandberg-Wollheim M, Laaksonen M, Myhr KM, Nyland H, Vartdal F, Spurkland A. Dai KZ, et al. Genes Immun. 2001 Aug;2(5):263-8. doi: 10.1038/sj.gene.6363774. Genes Immun. 2001. PMID: 11528519
The T cell specific adapter protein (TSAd) encoded by the SH2D2A gene is involved in the control of T cell activation. The gene is located in the 1q21 region, which has been implicated in susceptibility to experimental allergic encephalomyelitis in the mouse. ...Since the …
The T cell specific adapter protein (TSAd) encoded by the SH2D2A gene is involved in the control of T cell activation. The gene is lo …
The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.
Dai KZ, Vergnaud G, Ando A, Inoko H, Spurkland A. Dai KZ, et al. Immunogenetics. 2000 Mar;51(3):179-85. doi: 10.1007/s002510050029. Immunogenetics. 2000. PMID: 10752626
The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd), was isolated from a human Chromosome (Chr) 1 cosmid library (LLNL, UK HGMP). ...Physical mapping of a PAC and BAC contig containing the CD1 gene cluster telomeric to D1S2624 failed to identify a clone har …
The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd), was isolated from a human Chromosome (Chr) 1 cosmid library (LLN …
Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.
Smerdel A, Dai KZ, Lorentzen AR, Flatø B, Maslinski S, Thorsby E, Førre Ø, Spurkland A. Smerdel A, et al. Genes Immun. 2004 Jun;5(4):310-2. doi: 10.1038/sj.gene.6364093. Genes Immun. 2004. PMID: 15129233
T-cell-specific adapter protein (TSAd) involved in the negative control of T-cell activation is encoded by the SH2D2A gene. Our recent studies indicate that homozygosity for short (ie GA(13) and GA(16)) alleles of the SH2D2A gene promoter is associated with developm …
T-cell-specific adapter protein (TSAd) involved in the negative control of T-cell activation is encoded by the SH2D2A gene. Our recen …
Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene.
Notturno F, Pace M, De Angelis MV, Caporale CM, Giovannini A, Uncini A. Notturno F, et al. J Neuroimmunol. 2008 Jul 15;197(2):124-7. doi: 10.1016/j.jneuroim.2008.04.003. Epub 2008 Jun 3. J Neuroimmunol. 2008. PMID: 18533279
The SH2D2A gene encodes a T-cell-specific adapter protein involved in the negative control of T-cell activation. The genotype GA13-16 homozygote of the SH2D2A gene promoter has been associated with the susceptibility to develop multiple sclerosis. ...
The SH2D2A gene encodes a T-cell-specific adapter protein involved in the negative control of T-cell activation. The genotype GA13-16 …
A novel CD8+ T cell-related gene signature for predicting the prognosis and immunotherapy efficacy in bladder cancer.
Lin F, Ke ZB, Xue YT, Chen JY, Cai H, Lin YZ, Li XD, Wei Y, Xue XY, Xu N. Lin F, et al. Inflamm Res. 2023 Aug;72(8):1665-1687. doi: 10.1007/s00011-023-01772-6. Epub 2023 Aug 14. Inflamm Res. 2023. PMID: 37578544
Finally, preliminary experimental verifications were carried out to verify the biological functions of SH2D2A in bladder cancer. RESULTS: A total of 52 CD8(+) T cell-related prognostic genes were screened and two molecular clusters with notably diverse immune cell infiltra …
Finally, preliminary experimental verifications were carried out to verify the biological functions of SH2D2A in bladder cancer. RESU …
Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7.
Granum S, Sundvold-Gjerstad V, Dai KZ, Kolltveit KM, Hildebrand K, Huitfeldt HS, Lea T, Spurkland A. Granum S, et al. BMC Immunol. 2006 Jul 13;7:15. doi: 10.1186/1471-2172-7-15. BMC Immunol. 2006. PMID: 16839418 Free PMC article.
Here we examined expression of SH2D2A transcripts in activated CD4+ T cells and used the SH2D2A variants as tools to identify functionally important regions of TSAd. ...All five SH2D2A transcripts were found to be expressed in CD3 stimulated CD4+ T cells. ...
Here we examined expression of SH2D2A transcripts in activated CD4+ T cells and used the SH2D2A variants as tools to identify …
96 results