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Year Number of Results
2003 2
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2007 2
2008 2
2009 6
2010 1
2011 4
2012 2
2013 1
2014 2
2015 1
2016 1
2017 5
2018 3
2019 5
2020 5
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2024 6

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71 results

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Page 1
Anti-Scg3 Gene Therapy to Treat Choroidal Neovascularization in Mice.
Huang C, Ji L, Kaur A, Tian H, Waduge P, Webster KA, Li W. Huang C, et al. Biomedicines. 2023 Jul 6;11(7):1910. doi: 10.3390/biomedicines11071910. Biomedicines. 2023. PMID: 37509549 Free PMC article.
Anti-Scg3 antibodies synergize dose-dependently with VEGF inhibitors in a CNV model. ...The findings support further safety/efficacy studies of anti-Scg3 gene therapy as monotherapy or combined with anti-VEGF to treat nAMD....
Anti-Scg3 antibodies synergize dose-dependently with VEGF inhibitors in a CNV model. ...The findings support further safety/efficacy …
SCG3 Protein Expression in Glioma Associates With less Malignancy and Favorable Clinical Outcomes.
Wang Y, Ji N, Wang J, Cao J, Li D, Zhang Y, Zhang L. Wang Y, et al. Pathol Oncol Res. 2021 Feb 26;27:594931. doi: 10.3389/pore.2021.594931. eCollection 2021. Pathol Oncol Res. 2021. PMID: 34257545 Free PMC article.
Nearly a half of GBM cases (44.4%, 64/144) had any discernible SCG3 staining, and were defined as SCG3-positive by the microarray study. SCG3-positive GBM cases exhibited improved overall survival as compared with the SCG3-negative cases (29.3 vs. 14.5 …
Nearly a half of GBM cases (44.4%, 64/144) had any discernible SCG3 staining, and were defined as SCG3-positive by the microar …
Inhibitory effect of anti-Scg3 on corneal neovascularization: a preliminary study.
Jin H, Yang B, Jiang D, Ding Z, Xiong Y, Zeng X. Jin H, et al. BMC Ophthalmol. 2022 Nov 28;22(1):455. doi: 10.1186/s12886-022-02690-7. BMC Ophthalmol. 2022. PMID: 36443679 Free PMC article.
METHODS: Human umbilical vein endothelial cells (HUVECs) were treated with Scg3 and anti-Scg3. Cell proliferation, wound healing migration and tube formation assays were performed. ...RESULTS: In the in vitro study, the Scg3 antibody mixture inhibited Scg3 …
METHODS: Human umbilical vein endothelial cells (HUVECs) were treated with Scg3 and anti-Scg3. Cell proliferation, wound heali …
Safety and Efficacy of Systemic Anti-Scg3 Therapy to Treat Oxygen-Induced Retinopathy.
Dai C, Tian H, Bhatt A, Su G, Webster KA, Li W. Dai C, et al. Front Biosci (Landmark Ed). 2022 Apr 19;27(4):130. doi: 10.31083/j.fbl2704130. Front Biosci (Landmark Ed). 2022. PMID: 35468689 Free PMC article.
Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III (Scg3) is a disease-restricted angiogenic factor and that systemic anti-Scg3 mAb alleviates ROP in animal models with minimal …
Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III …
Secretogranin III: a diabetic retinopathy-selective angiogenic factor.
Li W, Webster KA, LeBlanc ME, Tian H. Li W, et al. Cell Mol Life Sci. 2018 Feb;75(4):635-647. doi: 10.1007/s00018-017-2635-5. Epub 2017 Aug 30. Cell Mol Life Sci. 2018. PMID: 28856381 Free PMC article. Review.
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation. ...
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 wa …
Optimal Efficacy and Safety of Humanized Anti-Scg3 Antibody to Alleviate Oxygen-Induced Retinopathy.
He Y, Tian H, Dai C, Wen R, Li X, Webster KA, Li W. He Y, et al. Int J Mol Sci. 2021 Dec 29;23(1):350. doi: 10.3390/ijms23010350. Int J Mol Sci. 2021. PMID: 35008775 Free PMC article.
., highlighting the urgent unmet clinical need for a novel therapeutic to treat the disease. Secretogranin III (Scg3) was recently identified as a disease-selective angiogenic factor, and Scg3-neutralizing monoclonal antibodies were reported to alleviate pathologica …
., highlighting the urgent unmet clinical need for a novel therapeutic to treat the disease. Secretogranin III (Scg3) was recently id …
SCG3 transcript in peripheral blood is a prognostic biomarker for REST-deficient small cell lung cancer.
Moss AC, Jacobson GM, Walker LE, Blake NW, Marshall E, Coulson JM. Moss AC, et al. Clin Cancer Res. 2009 Jan 1;15(1):274-83. doi: 10.1158/1078-0432.CCR-08-1163. Clin Cancer Res. 2009. PMID: 19118055
RESULTS: Expression profiling revealed multiple chromogranin transcripts were readily induced on REST depletion, most notably SCG3 was induced >500-fold. The SCG3 transcript was also overexpressed by 12,000-fold in neuroendocrine compared with nonneuroendocrine l …
RESULTS: Expression profiling revealed multiple chromogranin transcripts were readily induced on REST depletion, most notably SCG3 wa …
The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells.
Wang Y, Cui M, Cai X, Sun B, Liu F, Zhang X, Ye L. Wang Y, et al. Cancer Lett. 2014 Oct 1;352(2):169-78. doi: 10.1016/j.canlet.2014.05.007. Epub 2014 May 29. Cancer Lett. 2014. PMID: 24882622
HBXIP suppressed miR-509-3p through activating NF-kappaB. In function, we showed that SCG3 increased the proliferation of hepatoma cells and HBXIP enhanced the proliferation of the cells via SCG3 in vitro and in vivo. Thus, we conclude that HBXIP facilitates the pro …
HBXIP suppressed miR-509-3p through activating NF-kappaB. In function, we showed that SCG3 increased the proliferation of hepatoma ce …
Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization.
Ji L, Waduge P, Hao L, Kaur A, Wan W, Wu Y, Tian H, Zhang J, Webster KA, Li W. Ji L, et al. FASEB J. 2022 Jan;36(1):e22106. doi: 10.1096/fj.202101085RR. FASEB J. 2022. PMID: 34918375 Free PMC article.
Importantly, a combination of anti-Scg3 hFab and aflibercept synergistically alleviated CNV. Homozygous deletion of the Scg3 gene markedly reduced CNV severity and abolished the therapeutic activity of anti-Scg3 hFab, but not aflibercept, suggesting a role fo …
Importantly, a combination of anti-Scg3 hFab and aflibercept synergistically alleviated CNV. Homozygous deletion of the Scg3 g …
Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway.
Tang F, Pacheco MTF, Chen P, Liang D, Li W. Tang F, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):781-786. doi: 10.1016/j.bbrc.2017.11.080. Epub 2017 Nov 14. Biochem Biophys Res Commun. 2018. PMID: 29154827 Free PMC article.
Here we characterized the importance of MEK/ERK activation to Scg3 angiogenic activity. Our results showed that MEK inhibitor PD98059 blocked Scg3-induced proliferation of human umbilical vein endothelial cells (HUVECs). This finding was corroborated by PD98059 inhi …
Here we characterized the importance of MEK/ERK activation to Scg3 angiogenic activity. Our results showed that MEK inhibitor PD98059 …
71 results