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The Neuroprotective Role of Retbindin, a Metabolic Regulator in the Neural Retina.
Zhao X, Tebbe L, Naash MI, Al-Ubaidi MR. Zhao X, et al. Front Pharmacol. 2022 Jul 6;13:919667. doi: 10.3389/fphar.2022.919667. eCollection 2022. Front Pharmacol. 2022. PMID: 35873559 Free PMC article. Review.
Ablation of Rtbdn in these models accelerated the rate of retinal degeneration. ...This indicates that Rtbdn plays a neuroprotective role during retinal degeneration. Herein, we discussed the specific function of Rtbdn and its neuroprotective role in retinal …
Ablation of Rtbdn in these models accelerated the rate of retinal degeneration. ...This indicates that Rtbdn plays a neuroprot …
Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration.
Sinha T, Du J, Makia MS, Hurley JB, Naash MI, Al-Ubaidi MR. Sinha T, et al. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018956118. doi: 10.1073/pnas.2018956118. Proc Natl Acad Sci U S A. 2021. PMID: 33526685 Free PMC article.
We previously reported a model of progressive retinal degeneration resulting from the knockout of the retina-specific riboflavin binding protein, retbindin (Rtbdn(-/-) ). We also demonstrated a reduction in neural retinal flavins as a result of the elimination of RTBDN …
We previously reported a model of progressive retinal degeneration resulting from the knockout of the retina-specific riboflavin binding pro …
Elimination of a Retinal Riboflavin Binding Protein Exacerbates Degeneration in a Model of Cone-Rod Dystrophy.
Genc AM, Makia MS, Sinha T, Conley SM, Al-Ubaidi MR, Naash MI. Genc AM, et al. Invest Ophthalmol Vis Sci. 2020 Jun 3;61(6):17. doi: 10.1167/iovs.61.6.17. Invest Ophthalmol Vis Sci. 2020. PMID: 32516403 Free PMC article.
This hypothesis was supported by our findings that R172W mice lacking retbindin (Rtbdn-/-/Prph2R172W) exhibit functional and structural defects in rods and cones that are significantly worse than in controls. Retinal flavin levels were also altered in the Rtbdn-/-/P …
This hypothesis was supported by our findings that R172W mice lacking retbindin (Rtbdn-/-/Prph2R172W) exhibit functional and structur …
Retbindin: A riboflavin Binding Protein, Is Critical for Photoreceptor Homeostasis and Survival in Models of Retinal Degeneration.
Genc AM, Makia MS, Sinha T, Conley SM, Al-Ubaidi MR, Naash MI. Genc AM, et al. Int J Mol Sci. 2020 Oct 29;21(21):8083. doi: 10.3390/ijms21218083. Int J Mol Sci. 2020. PMID: 33138244 Free PMC article.
Rod and cone structural and functional degeneration worsened in models lacking RTBDN. In addition, removing Rtbdn worsened other phenotypes, such as fundus flecking. Retinal flavin levels were reduced in Rho(P23H/+)/Rtbdn(-/-) and Prph2(Y141C/+)/Rtbdn( …
Rod and cone structural and functional degeneration worsened in models lacking RTBDN. In addition, removing Rtbdn worsened oth …
Retbindin mediates light-damage in mouse retina while its absence leads to premature retinal aging.
Fan J, Rajapakse D, Peterson K, Lerner J, Parsa S, Ponduri A, Sagar V, Duncan T, Dong L, Wistow G. Fan J, et al. Exp Eye Res. 2021 Aug;209:108698. doi: 10.1016/j.exer.2021.108698. Epub 2021 Jul 3. Exp Eye Res. 2021. PMID: 34228964 Free PMC article.
Retbindin is a photoreceptor-specific protein, of unclear function, that is localized between the RPE and the tips of the photoreceptors. Unexpectedly, young Rtbdn-KO mice, with targeted deletion (KO) of retbindin, showed delayed regeneration of retinal function after blea …
Retbindin is a photoreceptor-specific protein, of unclear function, that is localized between the RPE and the tips of the photoreceptors. Un …
Retbindin Is Capable of Protecting Photoreceptors from Flavin-Sensitized Light-Mediated Cell Death In Vitro.
Kelley RA, Al-Ubaidi MR, Naash MI. Kelley RA, et al. Adv Exp Med Biol. 2018;1074:485-490. doi: 10.1007/978-3-319-75402-4_60. Adv Exp Med Biol. 2018. PMID: 29721980
Retbindin (Rtbdn) is a novel protein of unknown function found exclusively in the retina. ...Here we confirm that Rtbdn is capable of flavin binding and that this characteristic can protect photoreceptors from flavin-sensitized light damage....
Retbindin (Rtbdn) is a novel protein of unknown function found exclusively in the retina. ...Here we confirm that Rtbdn is cap …
Proteomic analysis of autoimmune retinopathy implicates NrCAM as a potential biomarker.
Al-Moujahed A, Velez G, Vu JT, Lima de Carvalho JR, Levi SR, Bassuk AG, Sepah YJ, Tsang SH, Mahajan VB. Al-Moujahed A, et al. Ophthalmol Sci. 2022 Jun;2(2):100131. doi: 10.1016/j.xops.2022.100131. Epub 2022 Feb 24. Ophthalmol Sci. 2022. PMID: 35529077 Free PMC article.
The most significantly downregulated proteins included disco-interacting protein 2 homolog (DIP2C), retbindin (RTBDN), and amyloid beta precursor like protein 2 (APLP2). Pathway analysis revealed that vascular endothelial growth factor (VEGF) signaling was a top represente …
The most significantly downregulated proteins included disco-interacting protein 2 homolog (DIP2C), retbindin (RTBDN), and amyloid be …
Alterations in egg white-related genes expression in response to hormonal stimulation.
Lee M, Yang C, Song G, Lim W. Lee M, et al. Reproduction. 2020 Nov;160(5):793-801. doi: 10.1530/REP-20-0342. Reproduction. 2020. PMID: 32985412
Subsequently, changes in the expression of genes encoding egg white proteins were confirmed in the oviduct tissue. The levels of MUC5B, ORM1, RTBDN, and TENP mRNA were significantly high in the oviduct, and the genes were repressed in the regression phase, whereas these we …
Subsequently, changes in the expression of genes encoding egg white proteins were confirmed in the oviduct tissue. The levels of MUC5B, ORM1 …
12 results