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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 2
2003 6
2004 8
2005 7
2006 11
2007 9
2008 18
2009 25
2010 24
2011 34
2012 25
2013 41
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2015 48
2016 47
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563 results

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N(7)-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.
Han H, Yang C, Ma J, Zhang S, Zheng S, Ling R, Sun K, Guo S, Huang B, Liang Y, Wang L, Chen S, Wang Z, Wei W, Huang Y, Peng H, Jiang YZ, Choe J, Lin S. Han H, et al. Nat Commun. 2022 Mar 18;13(1):1478. doi: 10.1038/s41467-022-29125-7. Nat Commun. 2022. PMID: 35304469 Free PMC article.
Mechanistically, METTL1 or WDR4 knockdown leads to decreased expression of m(7)G-modified tRNAs and reduces the translation of a subset of oncogenic transcripts enriched in RPTOR/ULK1/autophagy pathway. Furthermore, ESCC models using Mettl1 conditional knockout and knockin …
Mechanistically, METTL1 or WDR4 knockdown leads to decreased expression of m(7)G-modified tRNAs and reduces the translation of a subset of o …
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.Abbreviations: AKT1S1: AKT1 substrate 1; AMBRA1: autophagy and beclin 1 regula …
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting …
RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding.
Lin Y, Wu Y, Zhang Q, Tu X, Chen S, Pan J, Xu N, Lin M, She P, Niu G, Chen Y, Li H. Lin Y, et al. J Exp Clin Cancer Res. 2024 Jan 2;43(1):1. doi: 10.1186/s13046-023-02874-z. J Exp Clin Cancer Res. 2024. PMID: 38163890 Free PMC article.
Xenograft and zebrafish model were further employed to verify the cellular results. RESULTS: RNA sequencing and WES reported the involvement of RPTOR and ceramide metabolism in BM progress. RPTOR was significantly upregulated in BM foci and increased the permeabilit …
Xenograft and zebrafish model were further employed to verify the cellular results. RESULTS: RNA sequencing and WES reported the involvement …
RPTOR methylation in the peripheral blood and breast cancer in the Chinese population.
Yin Y, Lei S, Li L, Yang X, Yin Q, Xu T, Zhou W, Li H, Gu W, Ma F, Yang R, Zhang Z. Yin Y, et al. Genes Genomics. 2022 Apr;44(4):435-443. doi: 10.1007/s13258-021-01182-0. Epub 2021 Nov 12. Genes Genomics. 2022. PMID: 34767153
RESULTS: In our study, we found an association between BC and RPTOR_CpG_4 hypomethylation in the general population (per-10% of methylation, OR 1.29, P = 0.012), and a weak association between BC and RPTOR_CpG_8 hypomethylation in the women with older age (per-10% o …
RESULTS: In our study, we found an association between BC and RPTOR_CpG_4 hypomethylation in the general population (per-10% of methy …
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Cui Z, Napolitano G, de Araujo MEG, Esposito A, Monfregola J, Huber LA, Ballabio A, Hurley JH. Cui Z, et al. Nature. 2023 Feb;614(7948):572-579. doi: 10.1038/s41586-022-05652-7. Epub 2023 Jan 25. Nature. 2023. PMID: 36697823 Free PMC article.
Hypomethylation of RPTOR in peripheral blood is associated with very early-stage lung cancer.
Zhu Q, Qiao R, Di F, Song Y, Zhang J, Xu T, Wang Y, Dai L, Gu W, Han B, Yang R. Zhu Q, et al. Clin Chim Acta. 2022 Dec 1;537:173-180. doi: 10.1016/j.cca.2022.10.014. Epub 2022 Nov 1. Clin Chim Acta. 2022. PMID: 36332669

Combining the two studies, RPTOR_CpG_2 and RPTOR_CpG_8 showed significantly lower methylation levels in stage I cases (ORs per -10% methylation = 1.22 and 1.27, respectively, both P-values < 0.005). The significance kept between RPTOR_CpG_8 and LC cases wi

…
Combining the two studies, RPTOR_CpG_2 and RPTOR_CpG_8 showed significantly lower methylation levels in stage I cases (ORs per …
RPTOR mutation: a novel predictor of efficacious immunotherapy in melanoma.
Jiang Y, Hu X, Wang Z, Zhang Q, Chen D, Zhao P. Jiang Y, et al. Invest New Drugs. 2024 Feb;42(1):60-69. doi: 10.1007/s10637-023-01413-z. Epub 2023 Dec 10. Invest New Drugs. 2024. PMID: 38071684
RPTOR-Mut patients exhibited higher TMB than RPTOR-WT patients in both discovery and validation cohorts (P < 0.001). ...Immune cell infiltration analysis suggested that activated CD4 memory T cells were more enriched in RPTOR-Mut tumors. RPTOR-Mut m …
RPTOR-Mut patients exhibited higher TMB than RPTOR-WT patients in both discovery and validation cohorts (P < 0.001). ...Imm …
Autophagy drives fibroblast senescence through MTORC2 regulation.
Bernard M, Yang B, Migneault F, Turgeon J, Dieudé M, Olivier MA, Cardin GB, El-Diwany M, Underwood K, Rodier F, Hébert MJ. Bernard M, et al. Autophagy. 2020 Nov;16(11):2004-2016. doi: 10.1080/15548627.2020.1713640. Epub 2020 Jan 13. Autophagy. 2020. PMID: 31931659 Free PMC article.
Abbreviations: 3-MA: 3-methyladenine; ACTA2: actin, alpha 2, smooth muscle, aorta; AKT1: AKT serine/threonine kinase 1; p-AKT1: AKT1 Ser473 phosphorylation; t-AKT1: total AKT serine/threonine kinase 1; ATG4A: autophagy related 4A cysteine peptidase; ATG7: autophagy gene 7; C12FDG …
Abbreviations: 3-MA: 3-methyladenine; ACTA2: actin, alpha 2, smooth muscle, aorta; AKT1: AKT serine/threonine kinase 1; p-AKT1: AKT1 Ser473 …
563 results