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PRAF2 is an oncogene acting to promote the proliferation and invasion of breast cancer cells.
Wang Y, Zhao Z, Jiao W, Yin Z, Zhao W, Bo H, Bi Z, Dong B, Chen B, Wang Z. Wang Y, et al. Exp Ther Med. 2022 Nov 1;24(6):738. doi: 10.3892/etm.2022.11674. eCollection 2022 Dec. Exp Ther Med. 2022. PMID: 36478884 Free PMC article.
High expression of PRAF2 was verified by RT-qPCR in the breast cancer cell line, MCF-7, and small interfering RNA (siRNA) technology was used to silence PRAF2. ...Western blotting analysis results indicated that transfection with siRNA PRAF2 in MCF-7 cells de …
High expression of PRAF2 was verified by RT-qPCR in the breast cancer cell line, MCF-7, and small interfering RNA (siRNA) technology …
PRAF2 expression indicates unfavorable clinical outcome in hepatocellular carcinoma.
Wang CH, Liu LL, Liao DZ, Zhang MF, Fu J, Lu SX, Chen SL, Wang H, Cai SH, Zhang CZ, Zhang HZ, Yun JP. Wang CH, et al. Cancer Manag Res. 2018 Jul 25;10:2241-2248. doi: 10.2147/CMAR.S166789. eCollection 2018. Cancer Manag Res. 2018. PMID: 30100755 Free PMC article.
The prognostic implication of PRAF2 was verified by stratified survival analysis. The multivariate Cox regression model revealed PRAF2 as an independent poor prognostic factor for overall survival (hazard ratio = 1.244, 95% CI: 1.039-1.498, P<0.017) in HCC. ...Mo …
The prognostic implication of PRAF2 was verified by stratified survival analysis. The multivariate Cox regression model revealed P …
PRAF2 overexpression predicts poor prognosis and promotes tumorigenesis in esophageal squamous cell carcinoma.
Qian Z, Wei B, Zhou Y, Wang Q, Wang J, Sun Y, Gao Y, Chen X. Qian Z, et al. BMC Cancer. 2019 Jun 14;19(1):585. doi: 10.1186/s12885-019-5818-7. BMC Cancer. 2019. PMID: 31200670 Free PMC article.
The roles of PRAF2 in ESCC cells were investigated by proliferation, cell cycle, invasion and apoptosis assays in vitro. ...Survival analysis showed that high PRAF2 mRNA expression was associated with worse overall survival in ESCC patients. ...
The roles of PRAF2 in ESCC cells were investigated by proliferation, cell cycle, invasion and apoptosis assays in vitro. ...Survival …
Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper.
Da Silva E, Scott MGH, Enslen H, Marullo S. Da Silva E, et al. Int J Mol Sci. 2023 Dec 13;24(24):17438. doi: 10.3390/ijms242417438. Int J Mol Sci. 2023. PMID: 38139265 Free PMC article.
PRAF2 was also reported to interact in a two-hybrid screen with a peptide corresponding to the carboxyterminal tail of the chemokine receptor CCR5 despite the absence of RXR motifs in its sequence. ...PRAF2 and CD4 thus display opposite roles on the cell-surface exp …
PRAF2 was also reported to interact in a two-hybrid screen with a peptide corresponding to the carboxyterminal tail of the chemokine …
PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.
Yco LP, Geerts D, Koster J, Bachmann AS. Yco LP, et al. Int J Oncol. 2013 Apr;42(4):1408-16. doi: 10.3892/ijo.2013.1836. Epub 2013 Feb 21. Int J Oncol. 2013. PMID: 23440329
The shRNA-mediated PRAF2 downregulation in the SK-N-SH NB cell line resulted in decreased cellular proliferation, migration and matrix-attachment. ...The present study shows that PRAF2 plays an essential role in NB tumorigenesis and metastasis....
The shRNA-mediated PRAF2 downregulation in the SK-N-SH NB cell line resulted in decreased cellular proliferation, migration and matri …
JHDM1D-AS1 aggravates the development of gastric cancer through miR-450a-2-3p-PRAF2 axis.
Wu M, Liu Y, Pu YS, Ma Y, Wang JH, Liu EQ. Wu M, et al. Life Sci. 2021 Jan 15;265:118805. doi: 10.1016/j.lfs.2020.118805. Epub 2020 Nov 24. Life Sci. 2021. PMID: 33245963
Further, in vivo animal experiments were performed, and the expression levels of miR-450a-2-3p and PRAF2 in the tumor tissues were detected using qPCR and western blot analysis. ...JHDM1D-AS1/miR-450a-2-3p/PRAF2 axis may be a promising target for GC treatment....
Further, in vivo animal experiments were performed, and the expression levels of miR-450a-2-3p and PRAF2 in the tumor tissues were de …
Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.
Vento MT, Zazzu V, Loffreda A, Cross JR, Downward J, Stoppelli MP, Iaccarino I. Vento MT, et al. PLoS One. 2010 Dec 20;5(12):e15636. doi: 10.1371/journal.pone.0015636. PLoS One. 2010. PMID: 21203533 Free PMC article.
Among the several proteins co-purifying with Bcl-xL, we focused on Praf2, a protein with a predicted role in trafficking. The interaction of Praf2 with Bcl-xL was found to be dependent on the transmembrane domain of Bcl-xL. We found that Bcl-2 also interacts with …
Among the several proteins co-purifying with Bcl-xL, we focused on Praf2, a protein with a predicted role in trafficking. The interac …
Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites.
Saha K, Chevalier B, Doly S, Baatallah N, Guilbert T, Pranke I, Scott MGH, Enslen H, Guerrera C, Chuon C, Edelman A, Sermet-Gaudelus I, Hinzpeter A, Marullo S. Saha K, et al. Cell Mol Life Sci. 2022 Sep 27;79(10):530. doi: 10.1007/s00018-022-04554-1. Cell Mol Life Sci. 2022. PMID: 36167862
Because of its lower abundance, compared to wild-type CFTR, CFTR-F508del recruitment into COPII vesicles is suppressed by the ER-resident PRAF2. We also demonstrate that some pharmacological chaperones that efficiently rescue CFTR-F508del loss of function in CF patients ta …
Because of its lower abundance, compared to wild-type CFTR, CFTR-F508del recruitment into COPII vesicles is suppressed by the ER-resident …
Anatomical and ultrastructural study of PRAF2 expression in the mouse central nervous system.
Cifuentes-Diaz C, Marullo S, Doly S. Cifuentes-Diaz C, et al. Brain Struct Funct. 2016 Nov;221(8):4169-4185. doi: 10.1007/s00429-015-1159-8. Epub 2015 Dec 8. Brain Struct Funct. 2016. PMID: 26645984 Free article.
However, PRAF2 can interact with several receptors and immunofluorescence studies indicate that PRAF2 distribution is larger than the ER, suggesting additional biological functions. ...These data indicate additional modes of GABA(B) regulation in specific brain area …
However, PRAF2 can interact with several receptors and immunofluorescence studies indicate that PRAF2 distribution is larger t …
Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles.
Koomoa DL, Go RC, Wester K, Bachmann AS. Koomoa DL, et al. Neurosci Lett. 2008 May 9;436(2):171-6. doi: 10.1016/j.neulet.2008.03.030. Epub 2008 Mar 15. Neurosci Lett. 2008. PMID: 18395978
However, the function for PRAF2 remains unknown. In this study, we analyzed the distribution and localization of PRAF2 in the mature human brain using two new antibodies specific for the protein. ...Intriguingly, immunoblot analysis revealed that PRAF2 is enr …
However, the function for PRAF2 remains unknown. In this study, we analyzed the distribution and localization of PRAF2 in the …
23 results