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2003 2
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2008 3
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2013 7
2014 2
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105 results

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Combinational Deletions of MGF110-9L and MGF505-7R Genes from the African Swine Fever Virus Inhibit TBK1 Degradation by an Autophagy Activator PIK3C2B To Promote Type I Interferon Production.
Zhu G, Ren J, Li D, Ru Y, Qin X, Feng T, Tian H, Lu B, Shi D, Shi Z, Yang W, Zheng H. Zhu G, et al. J Virol. 2023 May 31;97(5):e0022823. doi: 10.1128/jvi.00228-23. Epub 2023 May 10. J Virol. 2023. PMID: 37162350 Free PMC article.
We also identified that the downregulation of an autophagy-related protein PIK3C2B was involved in the inhibition of TBK1 degradation induced by ASFV-delta110-9L/505-7R. Additionally, we also confirmed that PIK3C2B promoted ASFV-delta110-9L/505-7R replication in vit …
We also identified that the downregulation of an autophagy-related protein PIK3C2B was involved in the inhibition of TBK1 degradation …
Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression.
Maini J, Ghasemi M, Yandhuri D, Thakur SS, Brahmachari V. Maini J, et al. Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):196-204. doi: 10.1016/j.bbagrm.2016.12.003. Epub 2016 Dec 6. Biochim Biophys Acta Gene Regul Mech. 2017. PMID: 27932267
We have carried out an unbiased search for proteins interacting with human PRE-PIK3C2B (hPRE-PIK3C2B) based on DNA affinity purification followed by mass spectrometry and identified MLL, MLL4 and WDR87 among other proteins in three biological replicates in HEK, U87 …
We have carried out an unbiased search for proteins interacting with human PRE-PIK3C2B (hPRE-PIK3C2B) based on DNA affinity pu …
Higher PIK3C2B gene expression of H1N1+ specific B-cells is associated with lower H1N1 immunogenicity after trivalent influenza vaccination in HIV infected children.
Cotugno N, Zicari S, Morrocchi E, de Armas LR, Pallikkuth S, Rinaldi S, Ruggiero A, Manno EC, Zangari P, Chiriaco M, Bernardi S, Andrews SF, Cagigi A, Rossi P, McDermott AB, Pahwa S, Palma P. Cotugno N, et al. Clin Immunol. 2020 Jun;215:108440. doi: 10.1016/j.clim.2020.108440. Epub 2020 Apr 21. Clin Immunol. 2020. PMID: 32330555 Free PMC article.
H1N1-Sp transcriptional analysis revealed a distinct signature between PHIV and HC. NR presented higher PIK3C2B and NOD2 expression compared to R, confirmed by downregulation of PIK3C2B in resting-memory of R after H1N1 in-vitro stimulation. In conclusion this study …
H1N1-Sp transcriptional analysis revealed a distinct signature between PHIV and HC. NR presented higher PIK3C2B and NOD2 expression c …
PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.
Sabha N, Volpatti JR, Gonorazky H, Reifler A, Davidson AE, Li X, Eltayeb NM, Dall'Armi C, Di Paolo G, Brooks SV, Buj-Bello A, Feldman EL, Dowling JJ. Sabha N, et al. J Clin Invest. 2016 Sep 1;126(9):3613-25. doi: 10.1172/JCI86841. Epub 2016 Aug 22. J Clin Invest. 2016. PMID: 27548528 Free PMC article.
To test this, we targeted class II and III PI3 kinases (PI3Ks) in an MTM1-deficient mouse model. Muscle-specific ablation of Pik3c2b, but not Pik3c3, resulted in complete prevention of the MTM phenotype, and postsymptomatic targeting promoted a striking rescue of disease. …
To test this, we targeted class II and III PI3 kinases (PI3Ks) in an MTM1-deficient mouse model. Muscle-specific ablation of Pik3c2b, …
Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.
Gozzelino L, Kochlamazashvili G, Baldassari S, Mackintosh AI, Licchetta L, Iovino E, Liu YC, Bennett CA, Bennett MF, Damiano JA, Zsurka G, Marconi C, Giangregorio T, Magini P, Kuijpers M, Maritzen T, Norata GD, Baulac S, Canafoglia L, Seri M, Tinuper P, Scheffer IE, Bahlo M, Berkovic SF, Hildebrand MS, Kunz WS, Giordano L, Bisulli F, Martini M, Haucke V, Hirsch E, Pippucci T. Gozzelino L, et al. Brain. 2022 Jul 29;145(7):2313-2331. doi: 10.1093/brain/awac082. Brain. 2022. PMID: 35786744 Free PMC article.
Here, we show that defective lipid signalling caused by heterozygous ultra-rare variants in PIK3C2B, encoding for the class II phosphatidylinositol 3-kinase PI3K-C2beta, underlie focal epilepsy in humans. We demonstrate that patients' variants act as loss-of-function allel …
Here, we show that defective lipid signalling caused by heterozygous ultra-rare variants in PIK3C2B, encoding for the class II phosph …
ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway.
Sun RX, Zhu HJ, Zhang YR, Wang JN, Wang Y, Cao QC, Ji JD, Jiang C, Yuan ST, Chen X, Liu QH. Sun RX, et al. Cell Rep. 2023 Jul 25;42(7):112779. doi: 10.1016/j.celrep.2023.112779. Epub 2023 Jul 11. Cell Rep. 2023. PMID: 37436898 Free article.
Mechanistically, ALKBH5 regulates retinal features through its demethylation activity. It targets PIK3C2B and regulates the AKT/mTOR signaling pathway with YTHDF2 as the N(6)-methyladenosine reader. ...Collectively, we demonstrate that ALKBH5 induces RPE dysfunction and CN …
Mechanistically, ALKBH5 regulates retinal features through its demethylation activity. It targets PIK3C2B and regulates the AKT/mTOR …
Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis.
Kind M, Klukowska-Rötzler J, Berezowska S, Arcaro A, Charles RP. Kind M, et al. PLoS One. 2017 Oct 31;12(10):e0187308. doi: 10.1371/journal.pone.0187308. eCollection 2017. PLoS One. 2017. PMID: 29088297 Free PMC article.
In contrast to well characterized components of the PI3K signaling network contributing to the formation of SQCC, potential oncogenic effects of alterations in PIK3C2B are poorly understood. Here, a large cohort (n = 362) of NSCLC-SQCC was selectively screened for four rep …
In contrast to well characterized components of the PI3K signaling network contributing to the formation of SQCC, potential oncogenic effect …
Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer.
Liu Z, Li X, Ma J, Li D, Ju H, Liu Y, Chen Y, He X, Zhu Y. Liu Z, et al. Onco Targets Ther. 2020 Aug 20;13:8299-8311. doi: 10.2147/OTT.S257729. eCollection 2020. Onco Targets Ther. 2020. PMID: 32903879 Free PMC article.
In mechanistic studies, we found that IQGAP3 was positively coexpressed with PIK3C2B. In an in vitro assay, the PIK3C2B expression level was increased after exogenous overexpression of IQGAP3, resulting in the promotion of cell invasion, which was blocked by pretran …
In mechanistic studies, we found that IQGAP3 was positively coexpressed with PIK3C2B. In an in vitro assay, the PIK3C2B expres …
Integration of Selection Signatures and Protein Interactions Reveals NR6A1, PAPPA2, and PIK3C2B as the Promising Candidate Genes Underlying the Characteristics of Licha Black Pig.
Xie Q, Zhang Z, Chen Z, Sun J, Li M, Wang Q, Pan Y. Xie Q, et al. Biology (Basel). 2023 Mar 25;12(4):500. doi: 10.3390/biology12040500. Biology (Basel). 2023. PMID: 37106701 Free PMC article.
., NR6A1 and PAPPA2) and the fatness traits-related gene (i.e., PIK3C2B) were the promising candidate genes that closely related to the characteristics of LI pigs. ...The RNA expression data from FarmGTEx indicated that the RNA expression levels of NR6A1, PAPPA2, PIK3C2 …
., NR6A1 and PAPPA2) and the fatness traits-related gene (i.e., PIK3C2B) were the promising candidate genes that closely related to t …
105 results