Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development.
Ates KM, Wang T, Moreland T, Veeranan-Karmegam R, Ma M, Jeter C, Anand P, Wenzel W, Kim HG, Wolfe LA, Stephen J, Adams DR, Markello T, Tifft CJ, Settlage R, Gahl WA, Gonsalvez GB, Malicdan MC, Flanagan-Steet H, Pan YA.
Ates KM, et al.
Dis Model Mech. 2020 May 26;13(5):dmm041913. doi: 10.1242/dmm.041913.
Dis Model Mech. 2020.
PMID: 32152089
Free PMC article.
We found that impairment of both zebrafish orthologs, pheta1 and pheta2, disrupted endocytosis and ciliogenesis in renal tissues. In addition, pheta1/2 mutant animals exhibited reduced jaw size and delayed chondrocyte differentiation, indicating a role in craniofacial deve …
We found that impairment of both zebrafish orthologs, pheta1 and pheta2, disrupted endocytosis and ciliogenesis in renal tissues. In …