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Modeling, dynamics and phosphoinositide binding of the pleckstrin homology domain of two novel PLCs: η1 and η2.
Rai S, Mohanty P, Bhatnagar S. Rai S, et al. J Mol Graph Model. 2018 Oct;85:130-144. doi: 10.1016/j.jmgm.2018.07.012. Epub 2018 Aug 29. J Mol Graph Model. 2018. PMID: 30193228
The two novel PLCeta (1 and 2) possess an N-terminal PH domain (PHeta1 and PHeta2 respectively) that has been implicated in membrane association and induction of PLC activity. Understanding of the structure and dynamics is crucial for future modulation of lipid-protein int …
The two novel PLCeta (1 and 2) possess an N-terminal PH domain (PHeta1 and PHeta2 respectively) that has been implicated in membrane …
Ranking Breast Cancer Drugs and Biomarkers Identification Using Machine Learning and Pharmacogenomics.
Mehmood A, Nawab S, Jin Y, Hassan H, Kaushik AC, Wei DQ. Mehmood A, et al. ACS Pharmacol Transl Sci. 2023 Feb 24;6(3):399-409. doi: 10.1021/acsptsci.2c00212. eCollection 2023 Mar 10. ACS Pharmacol Transl Sci. 2023. PMID: 36926455 Free PMC article.
We have identified six drugs named Palbociclib, Panobinostat, PD-0325901, PLX4720, Selumetinib, and Tanespimycin that significantly perform on breast cancer cell lines. Also, five biomarkers named TNFSF15, DCAF6, KDM6A, PHETA2, and IFNGR1 are sensitive to all six shortlist …
We have identified six drugs named Palbociclib, Panobinostat, PD-0325901, PLX4720, Selumetinib, and Tanespimycin that significantly perform …
Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development.
Ates KM, Wang T, Moreland T, Veeranan-Karmegam R, Ma M, Jeter C, Anand P, Wenzel W, Kim HG, Wolfe LA, Stephen J, Adams DR, Markello T, Tifft CJ, Settlage R, Gahl WA, Gonsalvez GB, Malicdan MC, Flanagan-Steet H, Pan YA. Ates KM, et al. Dis Model Mech. 2020 May 26;13(5):dmm041913. doi: 10.1242/dmm.041913. Dis Model Mech. 2020. PMID: 32152089 Free PMC article.
We found that impairment of both zebrafish orthologs, pheta1 and pheta2, disrupted endocytosis and ciliogenesis in renal tissues. In addition, pheta1/2 mutant animals exhibited reduced jaw size and delayed chondrocyte differentiation, indicating a role in craniofacial deve …
We found that impairment of both zebrafish orthologs, pheta1 and pheta2, disrupted endocytosis and ciliogenesis in renal tissues. In …