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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1980 1
1981 1
1983 8
1984 12
1985 17
1986 16
1987 44
1988 53
1989 95
1990 93
1991 123
1992 264
1993 442
1994 603
1995 729
1996 698
1997 743
1998 695
1999 743
2000 773
2001 807
2002 852
2003 833
2004 816
2005 893
2006 943
2007 874
2008 896
2009 938
2010 984
2011 936
2012 1041
2013 1080
2014 963
2015 983
2016 981
2017 1013
2018 1031
2019 1018
2020 1118
2021 1066
2022 954
2023 815
2024 286

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25,809 results

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Page 1
Human PCNA Structure, Function and Interactions.
González-Magaña A, Blanco FJ. González-Magaña A, et al. Biomolecules. 2020 Apr 8;10(4):570. doi: 10.3390/biom10040570. Biomolecules. 2020. PMID: 32276417 Free PMC article. Review.
: Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. ...The unique binding mode of the oncogene p15 is described in detail, and the implications of the recently discovered structure of PCNA bou …
: Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. ...The …
PCNA Loaders and Unloaders-One Ring That Rules Them All.
Arbel M, Choudhary K, Tfilin O, Kupiec M. Arbel M, et al. Genes (Basel). 2021 Nov 18;12(11):1812. doi: 10.3390/genes12111812. Genes (Basel). 2021. PMID: 34828416 Free PMC article. Review.
During each cell duplication, the entirety of the genomic DNA in every cell must be accurately and quickly copied. ...One of the most important proteins for maintaining such coordination is PCNA. PCNA is a multitasking protein that forms a homotrimeric …
During each cell duplication, the entirety of the genomic DNA in every cell must be accurately and quickly copied. ...One of t …
Targeting PCNA with Peptide Mimetics for Therapeutic Purposes.
Horsfall AJ, Abell AD, Bruning JB. Horsfall AJ, et al. Chembiochem. 2020 Feb 17;21(4):442-450. doi: 10.1002/cbic.201900275. Epub 2019 Oct 15. Chembiochem. 2020. PMID: 31247123 Review.
Proliferating cell nuclear antigen (PCNA) is an excellent inhibition target to shut down highly proliferative cells and thereby develop a broad-spectrum cancer therapeutic. ...Such insights will allow a more directed approach to develop therapeu …
Proliferating cell nuclear antigen (PCNA) is an excellent inhibition target to shut down highly prolifera …
The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA.
Gu L, Lingeman R, Yakushijin F, Sun E, Cui Q, Chao J, Hu W, Li H, Hickey RJ, Stark JM, Yuan YC, Chen Y, Vonderfecht SL, Synold TW, Shi Y, Reckamp KL, Horne D, Malkas LH. Gu L, et al. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065. doi: 10.1158/1078-0432.CCR-18-0592. Epub 2018 Jul 2. Clin Cancer Res. 2018. PMID: 29967249 Free PMC article.
PURPOSE: Proliferating cell nuclear antigen (PCNA) plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell growth and survival. ...We found the L126-Y133 region of caPCNA is structurally altered …
PURPOSE: Proliferating cell nuclear antigen (PCNA) plays an essential role in regulating DNA synthesis an …
Small molecule targeting of transcription-replication conflict for selective chemotherapy.
Gu L, Li M, Li CM, Haratipour P, Lingeman R, Jossart J, Gutova M, Flores L, Hyde C, Kenjić N, Li H, Chung V, Li H, Lomenick B, Von Hoff DD, Synold TW, Aboody KS, Liu Y, Horne D, Hickey RJ, Perry JJP, Malkas LH. Gu L, et al. Cell Chem Biol. 2023 Oct 19;30(10):1235-1247.e6. doi: 10.1016/j.chembiol.2023.07.001. Epub 2023 Aug 1. Cell Chem Biol. 2023. PMID: 37531956 Free PMC article.
Targeting transcription replication conflicts, a major source of endogenous DNA double-stranded breaks and genomic instability could have important anticancer therapeutic implications. Proliferating cell nuclear antigen (PCNA) is critical to DNA …
Targeting transcription replication conflicts, a major source of endogenous DNA double-stranded breaks and genomic instability could have im …
'PIPs' in DNA polymerase: PCNA interaction affairs.
Acharya N, Patel SK, Sahu SR, Kumari P. Acharya N, et al. Biochem Soc Trans. 2020 Dec 18;48(6):2811-2822. doi: 10.1042/BST20200678. Biochem Soc Trans. 2020. PMID: 33196097 Review.
Interaction of PCNA with DNA polymerase is vital to efficient and processive DNA synthesis. ...PCNA interacting proteins contain a short sequence of eight amino acids, popularly coined as PIP motif, which snuggly fits into the hydrophobic pocket of PCNA to st …
Interaction of PCNA with DNA polymerase is vital to efficient and processive DNA synthesis. ...PCNA interacting proteins conta …
PCNA binding proteins.
Tsurimoto T. Tsurimoto T. Front Biosci. 1999 Dec 1;4:D849-58. doi: 10.2741/tsurimoto. Front Biosci. 1999. PMID: 10577396 Review.
PCNA (proliferating cell nuclear antigen), originally characterized as a DNA polymerase accessory protein, functions as a DNA sliding clamp for DNA polymerase delta and is an essential component for eukaryotic chromosomal DNA replication. ...Sin …
PCNA (proliferating cell nuclear antigen), originally characterized as a DNA polymerase accessory protein …
Functional hierarchy of PCNA-interacting motifs in DNA processing enzymes.
Hamdan SM, De Biasio A. Hamdan SM, et al. Bioessays. 2023 Jun;45(6):e2300020. doi: 10.1002/bies.202300020. Epub 2023 Apr 11. Bioessays. 2023. PMID: 37039277 Review.
Multiple PCNA-interacting motifs (PIPs) are present in these enzymes, but their individual structural and functional role has been a matter of debate. Recent cryo-EM reconstructions of high-fidelity DNA polymerase Pol delta (Pol delta), translesion synthesis DNA polymerase …
Multiple PCNA-interacting motifs (PIPs) are present in these enzymes, but their individual structural and functional role has been a …
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Røst LM, Ræder SB, Olaisen C, Søgaard CK, Sharma A, Bruheim P, Otterlei M. Røst LM, et al. Oncogene. 2023 Feb;42(8):613-624. doi: 10.1038/s41388-022-02579-1. Epub 2022 Dec 23. Oncogene. 2023. PMID: 36564470 Free PMC article.
The essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA replication and repair are well established, while its cytosolic roles are less explored. Two metabolic enzymes, alpha-enolase (ENO1) and 6-phosphogluc …
The essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA replication …
PCNA News.
[No authors listed] [No authors listed] J Cardiovasc Nurs. 2021 Jul-Aug 01;36(4):305-306. doi: 10.1097/JCN.0000000000000826. J Cardiovasc Nurs. 2021. PMID: 36036982 No abstract available.
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