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Page 1
Oosp1 encodes a novel mouse oocyte-secreted protein.
Yan C, Pendola FL, Jacob R, Lau AL, Eppig JJ, Matzuk MM. Yan C, et al. Genesis. 2001 Nov;31(3):105-10. doi: 10.1002/gene.10010. Genesis. 2001. PMID: 11747200
OOSP1 shares amino acid identity with placental-specific protein 1 (PLAC1), a secreted protein expressed in the placenta and the ectoplacental cone. The Oosp1 mRNA is approximately 1.0 kb and is present at high levels in the oocytes of adult ovaries and at lower lev …
OOSP1 shares amino acid identity with placental-specific protein 1 (PLAC1), a secreted protein expressed in the placenta and the ecto …
Identification and characterization of a novel bovine oocyte-specific secreted protein gene.
Tremblay K, Vigneault C, McGraw S, Morin G, Sirard MA. Tremblay K, et al. Gene. 2006 Jun 21;375:44-53. doi: 10.1016/j.gene.2006.02.006. Epub 2006 Mar 31. Gene. 2006. PMID: 16580794
We have sequenced the full-length mRNAs of bovine oocyte-secreted protein 1 (OOSP1) and discovered two splice variants, namely OOSP1_v1 (variant 1) and OOSP1_v2 (variant 2). ...Bovine OOSP1_v2 protein bears the same signal peptide as OOSP1_v1 bu …
We have sequenced the full-length mRNAs of bovine oocyte-secreted protein 1 (OOSP1) and discovered two splice variants, namely OOS …
Microarray analyses of newborn mouse ovaries lacking Nobox.
Choi Y, Qin Y, Berger MF, Ballow DJ, Bulyk ML, Rajkovic A. Choi Y, et al. Biol Reprod. 2007 Aug;77(2):312-9. doi: 10.1095/biolreprod.107.060459. Epub 2007 May 9. Biol Reprod. 2007. PMID: 17494914
Genes whose proteins are predicted to be secreted but were previously unknown to be significantly expressed in early oogenesis were downregulated in Nobox knockouts and included astacin-like metalloendopeptidase (Astl), Jagged 1 (Jag1), oocyte-secreted protein 1 (Oosp1), f …
Genes whose proteins are predicted to be secreted but were previously unknown to be significantly expressed in early oogenesis were downregu …
Germ cell-specific transcriptional regulator sohlh2 is essential for early mouse folliculogenesis and oocyte-specific gene expression.
Choi Y, Yuan D, Rajkovic A. Choi Y, et al. Biol Reprod. 2008 Dec;79(6):1176-82. doi: 10.1095/biolreprod.108.071217. Epub 2008 Aug 27. Biol Reprod. 2008. PMID: 18753606 Free PMC article.
However, the primordial oocytes are abnormal at the molecular level because they misexpress numerous germ cell- and oocyte-specific genes, including Sohlh1, Nobox, Figla, Gdf9, Pou5f1, Zp1, Zp3, Kit, Oosp1, Nlrp14, H1foo, and Stra8. Our findings show that Sohlh2 is a criti …
However, the primordial oocytes are abnormal at the molecular level because they misexpress numerous germ cell- and oocyte-specific genes, i …
CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice.
Abbasi F, Kodani M, Emori C, Kiyozumi D, Mori M, Fujihara Y, Ikawa M. Abbasi F, et al. Cells. 2020 Mar 28;9(4):821. doi: 10.3390/cells9040821. Cells. 2020. PMID: 32231122 Free PMC article.
To do this, our laboratory analyzes the functions of ovary and oocyte-enriched genes in vivo through generating CRISPR/Cas9 KO mice and examining their fertility. In this study, we have knocked out three Oosp family genes (Oosp1, Oosp2, and Oosp3) that have expression patt …
To do this, our laboratory analyzes the functions of ovary and oocyte-enriched genes in vivo through generating CRISPR/Cas9 KO mice and exam …
Molecular and cellular effects of insulin-like growth factor-1 and LongR3-IGF-1 on in vitro maturation of bovine oocytes: comparative study.
Araujo MS, Guastali MD, Paulini F, Silva AN, Tsunemi MH, Fontes PK, Castilho ACS, Landim-Alvarenga FC. Araujo MS, et al. Growth Horm IGF Res. 2020 Dec;55:101357. doi: 10.1016/j.ghir.2020.101357. Epub 2020 Sep 25. Growth Horm IGF Res. 2020. PMID: 33038561
Addition effects of insulin-like growth factor-1 (IGF-1) and its synthetic analogue insulin-like growth factor-1 recombinant-3 (LongR3-IGF-1) after in vitro maturation (IVM) of cattle cumulus-oocyte complexes (COCs) were compared and evaluated on meiotic progression, apoptosis an …
Addition effects of insulin-like growth factor-1 (IGF-1) and its synthetic analogue insulin-like growth factor-1 recombinant-3 (LongR3-IGF-1 …
Transcription profile of candidate genes for the acquisition of competence during oocyte growth in cattle.
Bessa IR, Nishimura RC, Franco MM, Dode MA. Bessa IR, et al. Reprod Domest Anim. 2013 Oct;48(5):781-9. doi: 10.1111/rda.12162. Epub 2013 Apr 11. Reprod Domest Anim. 2013. PMID: 23574109
The aim of this study was to investigate the expression profile of candidate genes involved in competence during oocyte growth. The candidate genes (BMP15, OOSP1, H1FOO, H2A, H3A, H4, SLBP, DNMT1, DNMT3B, HAT1, HDAC2 and SUV39H1) were selected because of their possible inv …
The aim of this study was to investigate the expression profile of candidate genes involved in competence during oocyte growth. The candidat …
Yin-yang1 is required in the mammalian oocyte for follicle expansion.
Griffith GJ, Trask MC, Hiller J, Walentuk M, Pawlak JB, Tremblay KD, Mager J. Griffith GJ, et al. Biol Reprod. 2011 Apr;84(4):654-63. doi: 10.1095/biolreprod.110.087213. Epub 2010 Dec 1. Biol Reprod. 2011. PMID: 21123818
Additionally, we find that YY1-deficient oocytes exhibit altered levels of several oocyte-specific factors, including Pou5f1, Figla, Lhx8, Oosp1, and Sohlh2. These results document YY1's involvement in folliculogenesis and ovarian function in the mouse and indicate that YY …
Additionally, we find that YY1-deficient oocytes exhibit altered levels of several oocyte-specific factors, including Pou5f1, Figla, Lhx8, …
The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation.
Jovine L, Janssen WG, Litscher ES, Wassarman PM. Jovine L, et al. BMC Biochem. 2006 Apr 6;7:11. doi: 10.1186/1471-2091-7-11. BMC Biochem. 2006. PMID: 16600035 Free PMC article.
ZP domain proteins perform highly diverse functions, ranging from structural to receptorial, and mutations in their genes are responsible for a number of severe human diseases. Recently, PLAC1, Oosp1-3, Papillote and CG16798 proteins were identified that share sequence hom …
ZP domain proteins perform highly diverse functions, ranging from structural to receptorial, and mutations in their genes are responsible fo …
Effect of follicle size on mRNA expression in cumulus cells and oocytes of Bos indicus: an approach to identify marker genes for developmental competence.
Caixeta ES, Ripamonte P, Franco MM, Junior JB, Dode MA. Caixeta ES, et al. Reprod Fertil Dev. 2009;21(5):655-64. doi: 10.1071/RD08201. Reprod Fertil Dev. 2009. PMID: 19486602
To identify the genes related to oocyte competence, we quantified transcripts for candidate genes in oocytes (H1Foo, H2A, H3A, GHR, GDF9, BMP15, OOSP1) and cumulus cells (FSHR, EGFR, GHR, PTX3, IGFII) using the follicle size model to select oocytes of better developmental …
To identify the genes related to oocyte competence, we quantified transcripts for candidate genes in oocytes (H1Foo, H2A, H3A, GHR, GDF9, BM …
13 results