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Year Number of Results
1998 1
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2008 6
2009 4
2010 6
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302 results

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piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2.
Wang Q, Chen P, Wang X, Wu Y, Xia K, Mu X, Xuan Q, Xiao J, He Y, Liu W, Song X, Sun F. Wang Q, et al. Noncoding RNA Res. 2023 Jan 7;8(2):174-186. doi: 10.1016/j.ncrna.2022.12.004. eCollection 2023 Jun. Noncoding RNA Res. 2023. PMID: 36710986 Free PMC article.
Here, we show that OAS2 knockdown also promotes testicular cancer cell proliferation and migration. Furthermore, piR-36249 interacts with DHX36, which has been reported to promote translation. DHX36 can also bind to OAS2 mRNA, and knockdown of DHX36 increases OAS …
Here, we show that OAS2 knockdown also promotes testicular cancer cell proliferation and migration. Furthermore, piR-36249 interacts …
Prognostic characterization of OAS1/OAS2/OAS3/OASL in breast cancer.
Zhang Y, Yu C. Zhang Y, et al. BMC Cancer. 2020 Jun 19;20(1):575. doi: 10.1186/s12885-020-07034-6. BMC Cancer. 2020. PMID: 32560641 Free PMC article.
The 2'-5'-oligoadenylate synthetases (OAS), composing of OAS1, OAS2, OAS3, and OAS-like (OASL), are interferon (IFN)-induced antiviral enzymes, with their prognostic roles remain to be characterized. ...In DNA methylation level, cg12560128 in OAS2, cg06800840 and cg …
The 2'-5'-oligoadenylate synthetases (OAS), composing of OAS1, OAS2, OAS3, and OAS-like (OASL), are interferon (IFN)-induced antivira …
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X; CoV-Contact Cohort§; COVID Human Genetic Effort¶; Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard CL, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL. Lee D, et al. Science. 2023 Feb 10;379(6632):eabo3627. doi: 10.1126/science.abo3627. Epub 2023 Feb 10. Science. 2023. PMID: 36538032 Free PMC article.
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing O …
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal reces …
OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1-Induced Jak1-Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
Huang YZ, Zheng YX, Zhou Y, Xu F, Cui YZ, Chen XY, Wang ZY, Yan BX, Zheng M, Man XY. Huang YZ, et al. J Invest Dermatol. 2022 Oct;142(10):2635-2645.e9. doi: 10.1016/j.jid.2022.02.018. Epub 2022 Mar 16. J Invest Dermatol. 2022. PMID: 35305973 Free article.
Recent studies have identified IL-17 and IL-23 as key drivers of psoriasis pathogenesis, but the underlying molecular mechanisms remain unclear. The 2'-5'-oligoadenylate synthetases (OASs), namely, OAS1, OAS2, OAS3, and OASL, are a family of IFN-induced enzymes with multip …
Recent studies have identified IL-17 and IL-23 as key drivers of psoriasis pathogenesis, but the underlying molecular mechanisms remain uncl …
OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and enhance cytokine secretion.
Leisching G, Cole V, Ali AT, Baker B. Leisching G, et al. Int J Infect Dis. 2019 Mar;80S:S77-S84. doi: 10.1016/j.ijid.2019.02.029. Epub 2019 Feb 26. Int J Infect Dis. 2019. PMID: 30822544 Free article.
The 2',5' (OASs) are known as mediators of the antiviral response system through activation of the RNA cleavage pathway. Interestingly, we observe OAS1, OAS2 and OAS3 upregulation in a number of gene expression signatures which discriminate active TB from latent TB infecti …
The 2',5' (OASs) are known as mediators of the antiviral response system through activation of the RNA cleavage pathway. Interestingly, we o …
2', 5'-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type iota IFN Signaling Pathway.
Liao X, Xie H, Li S, Ye H, Li S, Ren K, Li Y, Xu M, Lin W, Duan X, Yang C, Chen L. Liao X, et al. Viruses. 2020 Apr 8;12(4):418. doi: 10.3390/v12040418. Viruses. 2020. PMID: 32276512 Free PMC article.
However, the role of OAS2 on Zika virus (ZIKV) replication is still unknown. In this study, we sought to explore the effect of OAS2 on ZIKV replication and its underlying mechanism. ...Interferon stimulated response element (ISRE) activity was examined by dual lucif …
However, the role of OAS2 on Zika virus (ZIKV) replication is still unknown. In this study, we sought to explore the effect of OAS …
Genetic mechanisms of critical illness in COVID-19.
Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira AC, Renieri A; GenOMICC Investigators; ISARIC4C Investigators; COVID-19 Human Genetics Initiative; 23andMe Investigators; BRACOVID Investigators; Gen-COVID Investigators; Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK. Pairo-Castineira E, et al. Nature. 2021 Mar;591(7848):92-98. doi: 10.1038/s41586-020-03065-y. Epub 2020 Dec 11. Nature. 2021. PMID: 33307546
We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 10(-8)) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P …
We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 10(-8 …
Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases.
Ho WJ, Law AMK, Masle-Farquhar E, Castillo LE, Mawson A, O'Bryan MK, Goodnow CC, Gallego-Ortega D, Oakes SR, Ormandy CJ. Ho WJ, et al. Breast Cancer Res. 2022 May 3;24(1):31. doi: 10.1186/s13058-022-01525-z. Breast Cancer Res. 2022. PMID: 35505346 Free PMC article.
RESULTS: Oas2 mutation prevented pregnancy from increasing metastases to lung. Checkpoint immunotherapy with antibodies against programmed death-ligand 1 was more effective when the Oas2 mutation was present. CONCLUSIONS: These data establish OAS2 as a therap …
RESULTS: Oas2 mutation prevented pregnancy from increasing metastases to lung. Checkpoint immunotherapy with antibodies against progr …
Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity.
Zhou Y, Wang P, Yan BX, Chen XY, Landeck L, Wang ZY, Li XX, Zhang J, Zheng M, Man XY. Zhou Y, et al. Front Immunol. 2020 Jul 31;11:1432. doi: 10.3389/fimmu.2020.01432. eCollection 2020. Front Immunol. 2020. PMID: 32849499 Free PMC article.
Moreover, OAS2 expression in psoriatic skin significantly decreased after IL-17R mono-antibody treatment. ...Keratinocyte-derived OAS2 can be induced by not only IFNbeta, but also psoriasis associated cytokines like IL-17A and IL-6. ...
Moreover, OAS2 expression in psoriatic skin significantly decreased after IL-17R mono-antibody treatment. ...Keratinocyte-derived …
Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).
Koul A, Deo S, Booy EP, Orriss GL, Genung M, McKenna SA. Koul A, et al. Biochem Cell Biol. 2020 Feb;98(1):70-82. doi: 10.1139/bcb-2019-0060. Epub 2019 Apr 9. Biochem Cell Biol. 2020. PMID: 30965010
In this study, we probed the RNA cofactor specificity of the two smallest isozymes, OAS1 and OAS2. First, we developed a strategy for the expression and purification of recombinant human OAS2 from eukaryotic cells and quantified the activity of the enzyme relative t …
In this study, we probed the RNA cofactor specificity of the two smallest isozymes, OAS1 and OAS2. First, we developed a strategy for …
302 results