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NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity.
Nakashima A, Yamaguchi H, Kondo M, Furumura T, Kodani Y, Kaneko YS, Kawata M, Nagasaki H, Nagatsu T, Ota A. Nakashima A, et al. J Neural Transm (Vienna). 2020 Dec;127(12):1631-1640. doi: 10.1007/s00702-020-02236-5. Epub 2020 Aug 10. J Neural Transm (Vienna). 2020. PMID: 32778969
We recently reported that NT5DC2 binds to tyrosine hydroxylase (TH) and that the down-regulation of NT5DC2 tended to increase DA synthesis. ...Moreover, the induction of kinase activity by forskolin markedly potentiated the phosphorylation of TH at its Ser40 in PC12 …
We recently reported that NT5DC2 binds to tyrosine hydroxylase (TH) and that the down-regulation of NT5DC2 tended to increase …
NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn.
Guo S, Ran H, Xiao D, Huang H, Mi L, Wang X, Chen L, Li D, Zhang S, Han Q, Zhou T, Li A, Man J. Guo S, et al. Cancer Lett. 2019 Jul 10;454:98-107. doi: 10.1016/j.canlet.2019.04.003. Epub 2019 Apr 10. Cancer Lett. 2019. PMID: 30978441
NT5DC2 is preferentially expressed in GSCs relative to the non-stem tumor cells. ...Taken together, our results uncover the function of NT5DC2 in GSC maintenance and highlight NT5DC2 as a promising therapeutic target for GBM....
NT5DC2 is preferentially expressed in GSCs relative to the non-stem tumor cells. ...Taken together, our results uncover the function …
NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma.
Li KS, Zhu XD, Liu HD, Zhang SZ, Li XL, Xiao N, Liu XF, Xu B, Lei M, Zhang YY, Shi WK, Cao MQ, Xu YF, Tang ZY, Sun HC. Li KS, et al. Cell Death Dis. 2020 May 7;11(5):335. doi: 10.1038/s41419-020-2549-2. Cell Death Dis. 2020. PMID: 32382041 Free PMC article.
NT5DC2 expression was also independently associated with recurrence-free survival. ...EGFR blockage could be used to treat selected patients with NT5DC2 upregulation....
NT5DC2 expression was also independently associated with recurrence-free survival. ...EGFR blockage could be used to treat selected p …
Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients.
Sha R, Zhang J, Meng F, Zhaori G. Sha R, et al. Medicine (Baltimore). 2023 Oct 6;102(40):e35030. doi: 10.1097/MD.0000000000035030. Medicine (Baltimore). 2023. PMID: 37800836 Free PMC article.
Among which, NT5DC2 was screened as the target gene for subsequent study. The NT5DC2 expression were increased in primary GC and metastatic GC samples. Moreover, GC patients with high NT5DC2 expression exhibited shorter overall survival and post progression s …
Among which, NT5DC2 was screened as the target gene for subsequent study. The NT5DC2 expression were increased in primary GC a …
NT5DC2 is a novel prognostic marker in human hepatocellular carcinoma.
Chen J, Cao J, Wang P, He X. Chen J, et al. Oncol Lett. 2020 Oct;20(4):70. doi: 10.3892/ol.2020.11931. Epub 2020 Jul 29. Oncol Lett. 2020. PMID: 32863903 Free PMC article.
Therefore, the present study aimed to resolve these functions by analyzing the prognostic value of NT5DC2 in patients with HCC. A tissue microarray (TMA) was prepared and NT5DC2 expression was measured via IHC staining in TMA dots. ...In the multivariate Cox regress …
Therefore, the present study aimed to resolve these functions by analyzing the prognostic value of NT5DC2 in patients with HCC. A tis …
NT5DC2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling.
Jin X, Liu X, Zhang Z, Xu L. Jin X, et al. Biochem Biophys Res Commun. 2020 Dec 10;533(3):354-361. doi: 10.1016/j.bbrc.2020.06.139. Epub 2020 Sep 19. Biochem Biophys Res Commun. 2020. PMID: 32962856
NT5DC2 plays an essential role in cancer development. The purpose of the study was to explore NT5DC2's role in tumorigenesis and its potential mechanisms in NSCLC. ...Mechanistically, p53 might be a target of NT5DC2. The expression of p53 was highly induced i …
NT5DC2 plays an essential role in cancer development. The purpose of the study was to explore NT5DC2's role in tumorigenesis a …
High Expression of NT5DC2 Is a Negative Prognostic Marker in Pulmonary Adenocarcinoma.
Schulze AB, Kuntze A, Schmidt LH, Mohr M, Marra A, Hillejan L, Schulz C, Görlich D, Hartmann W, Bleckmann A, Evers G. Schulze AB, et al. Cancers (Basel). 2022 Mar 9;14(6):1395. doi: 10.3390/cancers14061395. Cancers (Basel). 2022. PMID: 35326547 Free PMC article.
Via immunohistochemistry (IHC) on tissue micro arrays (TMA) clinical and prognostic impact of p53 co-playing 5'-Nucleotidase Domain-Containing Protein 2 (NT5DC2) protein expression was evaluated in 252 NSCLC patients. Confirmatory, gene expression database. mRNA levels of …
Via immunohistochemistry (IHC) on tissue micro arrays (TMA) clinical and prognostic impact of p53 co-playing 5'-Nucleotidase Domain-Containi …
NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.
Hu B, Zhou S, Hu X, Zhang H, Lan X, Li M, Wang Y, Hu Q. Hu B, et al. J Cell Mol Med. 2021 Jul;25(13):5976-5987. doi: 10.1111/jcmm.16409. Epub 2021 May 16. J Cell Mol Med. 2021. PMID: 33993634 Free PMC article.
5'-Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncoprotein, the regulatory effects of which have not been well characterized. ...Dual-luciferase assay demonstrated that TEAD4 could bind to the NT5DC2 promoter and activate its transcription. Based on these f …
5'-Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncoprotein, the regulatory effects of which have not been well characterized …
Low NT5DC2 expression predicts favorable prognosis and suppresses soft tissue sarcoma progression via ECM-receptor interaction pathway.
Huang Z, Xu E, Ma X, Wang Y, Zhu J, Zhu K, Hu J, Zhang C. Huang Z, et al. Transl Oncol. 2024 Jun;44:101937. doi: 10.1016/j.tranon.2024.101937. Epub 2024 Mar 27. Transl Oncol. 2024. PMID: 38547613 Free PMC article.
The NT5DC2 protein expression in sarcoma tissues in our hospital was detected by using immunohistochemistry (IHC) and analyzed the associations between NT5DC2 expression and clinicopathological parameters. ...Additionally, IHC staining showed that 40 % of soft tissu …
The NT5DC2 protein expression in sarcoma tissues in our hospital was detected by using immunohistochemistry (IHC) and analyzed the as …
NT5DC2 knockdown inhibits colorectal carcinoma progression by repressing metastasis, angiogenesis and tumor-associated macrophage recruitment: A mechanism involving VEGF signaling.
Zhu Z, Hou Q, Guo H. Zhu Z, et al. Exp Cell Res. 2020 Dec 1;397(1):112311. doi: 10.1016/j.yexcr.2020.112311. Epub 2020 Sep 28. Exp Cell Res. 2020. PMID: 32991874
Here, we explored the potential of NT5DC2 on tumor progression in CRC. We first found that NT5DC2 expression was significantly up-regulated in CRC tissues and cell lines. ...Lung metastasis of CRC cells was also hindered by NT5DC2 deletion in vivo. Collective …
Here, we explored the potential of NT5DC2 on tumor progression in CRC. We first found that NT5DC2 expression was significantly …
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