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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 5
1993 3
1994 2
1995 4
1996 1
1997 3
1998 5
1999 6
2000 8
2001 13
2002 11
2003 9
2004 15
2005 15
2006 27
2007 18
2008 24
2009 25
2010 25
2011 40
2012 37
2013 42
2014 52
2015 44
2016 39
2017 49
2018 47
2019 41
2020 38
2021 29
2022 39
2023 30
2024 9

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683 results

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Page 1
MTA1: A Vital Modulator in Prostate Cancer.
Ma J, Li C, Qian H, Zhang Y. Ma J, et al. Curr Protein Pept Sci. 2022;23(7):456-464. doi: 10.2174/1389203723666220705152713. Curr Protein Pept Sci. 2022. PMID: 35792131 Review.
MTA1 has been demonstrated to play a significant role in the formation, progression, and metastasis of PCa, and MTA1 expression is specifically linked to PCa bone metastases. ...Here, we reviewed the structure, function, and expression of MTA1 in PCa as well …
MTA1 has been demonstrated to play a significant role in the formation, progression, and metastasis of PCa, and MTA1 expressio …
RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis.
Yin X, Teng X, Ma T, Yang T, Zhang J, Huo M, Liu W, Yang Y, Yuan B, Yu H, Huang W, Wang Y. Yin X, et al. Cell Death Differ. 2022 Nov;29(11):2203-2217. doi: 10.1038/s41418-022-01010-2. Epub 2022 May 9. Cell Death Differ. 2022. PMID: 35534547 Free PMC article.
Here, we show that RUNX2 recruits the metastasis-associated 1 (MTA1)/NuRD and the Cullin 4B (CUL4B)-Ring E3 ligase (CRL4B) complex to form a transcriptional-repressive complex, which catalyzes the histone deacetylation and ubiquitylation. ...We demonstrate that the RUNX2/N …
Here, we show that RUNX2 recruits the metastasis-associated 1 (MTA1)/NuRD and the Cullin 4B (CUL4B)-Ring E3 ligase (CRL4B) complex to …
MTA1, a Novel ATP Synthase Complex Modulator, Enhances Colon Cancer Liver Metastasis by Driving Mitochondrial Metabolism Reprogramming.
Wang T, Sun F, Li C, Nan P, Song Y, Wan X, Mo H, Wang J, Zhou Y, Guo Y, Helali AE, Xu D, Zhan Q, Ma F, Qian H. Wang T, et al. Adv Sci (Weinh). 2023 Sep;10(25):e2300756. doi: 10.1002/advs.202300756. Epub 2023 Jul 13. Adv Sci (Weinh). 2023. PMID: 37442756 Free PMC article.
High-throughput screening of an anticancer drug shows MTA1 knockout increases the sensitivity of colon cancer to mitochondrial bioenergetic metabolism-targeted drugs and mTOR inhibitors. Inhibiting ATP5A enhances the sensitivity of liver-metastasized colon cancer to siroli …
High-throughput screening of an anticancer drug shows MTA1 knockout increases the sensitivity of colon cancer to mitochondrial bioene …
MTA1 expression in human cancers - Clinical and pharmacological significance.
Malisetty VL, Penugurti V, Panta P, Chitta SK, Manavathi B. Malisetty VL, et al. Biomed Pharmacother. 2017 Nov;95:956-964. doi: 10.1016/j.biopha.2017.09.025. Epub 2017 Sep 11. Biomed Pharmacother. 2017. PMID: 28915537 Review.
Considering its close association with aggressiveness in human cancers, MTA1 may be considered as a potential therapeutic target for cancer treatment. The recent developments in its crystal structure further strengthened the idea of developing small molecule inhibitors for …
Considering its close association with aggressiveness in human cancers, MTA1 may be considered as a potential therapeutic target for …
Role of MTA1 in cancer progression and metastasis.
Sen N, Gui B, Kumar R. Sen N, et al. Cancer Metastasis Rev. 2014 Dec;33(4):879-89. doi: 10.1007/s10555-014-9515-3. Cancer Metastasis Rev. 2014. PMID: 25344802 Free PMC article. Review.
In the case of MTA1, these functions are manifested through posttranslational modifications of MTA1 in response to upstream signals, MTA1 interaction with binding proteins, and the expression of target gene products. Studies delineating the molecular basis of …
In the case of MTA1, these functions are manifested through posttranslational modifications of MTA1 in response to upstream si …
Towards an understanding of the structure and function of MTA1.
Millard CJ, Fairall L, Schwabe JW. Millard CJ, et al. Cancer Metastasis Rev. 2014 Dec;33(4):857-67. doi: 10.1007/s10555-014-9513-5. Cancer Metastasis Rev. 2014. PMID: 25352341 Free PMC article. Review.
MTA1 consists of four characterised domains, a number of interaction motifs, and regions that are predicted to be intrinsically disordered. ...MTA1 is highly upregulated in several types of aggressive tumours and is therefore a possible target for cancer therapy. .. …
MTA1 consists of four characterised domains, a number of interaction motifs, and regions that are predicted to be intrinsically disor …
MTA1 as negative prognostic marker in vulvar carcinoma.
Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C. Wanka G, et al. J Cancer Res Clin Oncol. 2023 Aug;149(9):6191-6201. doi: 10.1007/s00432-023-04579-4. Epub 2023 Jan 23. J Cancer Res Clin Oncol. 2023. PMID: 36689059 Free PMC article.
Due to the lack of information around MTA1 and its significance regarding vulvar carcinoma, this study focuses on the expression of MTA1 in vulvar carcinoma and its correlation to clinicopathological characteristics and prognosis. ...RESULTS: MTA1 was found t …
Due to the lack of information around MTA1 and its significance regarding vulvar carcinoma, this study focuses on the expression of …
MTA1-TJP1 interaction and its involvement in non-small cell lung cancer metastasis.
Wang W, Ma M, Li L, Huang Y, Zhao G, Zhou Y, Yang Y, Yang Y, Wang B, Ye L. Wang W, et al. Transl Oncol. 2022 Nov;25:101500. doi: 10.1016/j.tranon.2022.101500. Epub 2022 Aug 6. Transl Oncol. 2022. PMID: 35944414 Free PMC article.
MTA1 inhibited the expression level of TJP1 protein and weakened the tight junctions between cells. ...Thus, targeting the MTA1-TJP1 axis may be a promising strategy for inhibiting NSCLC metastasis....
MTA1 inhibited the expression level of TJP1 protein and weakened the tight junctions between cells. ...Thus, targeting the MTA1 …
MTA1--a stress response protein: a master regulator of gene expression and cancer cell behavior.
Wang RA. Wang RA. Cancer Metastasis Rev. 2014 Dec;33(4):1001-9. doi: 10.1007/s10555-014-9525-1. Cancer Metastasis Rev. 2014. PMID: 25332145 Free PMC article. Review.
In this review, I try to elucidate MTA1's role in both carcinogenesis and metastasis from a different angle. I propose that MTA1 is a stress response protein that is upregulated in various stress-related situations such as heat shock, hypoxia, and ironic radiation. …
In this review, I try to elucidate MTA1's role in both carcinogenesis and metastasis from a different angle. I propose that MTA1 …
MTA1, a metastasis-associated protein, in endothelial cells is an essential molecule for angiogenesis.
Ishikawa M, Osaki M, Uno N, Ohira T, Kugoh H, Okada F. Ishikawa M, et al. Mol Med Rep. 2022 Jan;25(1):11. doi: 10.3892/mmr.2021.12527. Epub 2021 Nov 15. Mol Med Rep. 2022. PMID: 34779499 Free PMC article.
The present study aimed to clarify the importance of MTA1 expression in tube formation using MTA1-knockout (KO) endothelial cells (MTA1-KO MSS31 cells). Tube formation was significantly suppressed in MTA1-KO MSS31 cells, whereas MTA1-overexpress …
The present study aimed to clarify the importance of MTA1 expression in tube formation using MTA1-knockout (KO) endothelial ce …
683 results