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63 results

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MNS1 promotes hepatocarcinogenesis and metastasis via activating PI3K/AKT by translocating beta-catenin and predicts poor prognosis.
Yi Y, Yu MC, Fu PY, Liu G, Zhou PY, Guan RY, Zhou C, Sun BY, Qiu SJ. Yi Y, et al. Liver Int. 2021 Jun;41(6):1409-1420. doi: 10.1111/liv.14803. Epub 2021 Feb 16. Liver Int. 2021. PMID: 33506565
NOD/SCID/gammac(null) (NOG) mice model was adopted to investigate functions of MNS1 in vivo. RESULTS: The expression of MNS1, which is elevated in most HCC tissues, correlated with poor survival in HCC patients. ...MNS1 indirectly translocated beta-catenin fr …
NOD/SCID/gammac(null) (NOG) mice model was adopted to investigate functions of MNS1 in vivo. RESULTS: The expression of MNS1, …
MNS1 variant associated with situs inversus and male infertility.
Leslie JS, Rawlins LE, Chioza BA, Olubodun OR, Salter CG, Fasham J, Jones HF, Cross HE, Lam S, Harlalka GV, Muggenthaler MMA, Crosby AH, Baple EL. Leslie JS, et al. Eur J Hum Genet. 2020 Jan;28(1):50-55. doi: 10.1038/s41431-019-0489-z. Epub 2019 Sep 18. Eur J Hum Genet. 2020. PMID: 31534215 Free PMC article.
This identified a single shared (2.34 Mb) region of autozygosity on chromosome 15q21.3 as the likely disease locus, in which we identified a single candidate biallelic frameshift variant in MNS1 [NM_018365.2: c.407_410del; p.(Glu136Glyfs*16)]. Genotyping of multiple family …
This identified a single shared (2.34 Mb) region of autozygosity on chromosome 15q21.3 as the likely disease locus, in which we identified a …
MNS1 is essential for spermiogenesis and motile ciliary functions in mice.
Zhou J, Yang F, Leu NA, Wang PJ. Zhou J, et al. PLoS Genet. 2012;8(3):e1002516. doi: 10.1371/journal.pgen.1002516. Epub 2012 Mar 1. PLoS Genet. 2012. PMID: 22396656 Free PMC article.
In addition, MNS1-deficient mice display situs inversus and hydrocephalus. MNS1-deficient tracheal motile cilia lack some outer dynein arms in the axoneme. Moreover, MNS1 monomers interact with each other and are able to form polymers in cultured somatic cell …
In addition, MNS1-deficient mice display situs inversus and hydrocephalus. MNS1-deficient tracheal motile cilia lack some oute …
Identification MNS1, FRZB, OGN, LUM, SERP1NA3 and FCN3 as the potential immune-related key genes involved in ischaemic cardiomyopathy by random forest and nomogram.
Zheng PF, Liu F, Zheng ZF, Pan HW, Liu ZY. Zheng PF, et al. Aging (Albany NY). 2023 Feb 27;15(5):1475-1495. doi: 10.18632/aging.204547. Epub 2023 Feb 27. Aging (Albany NY). 2023. PMID: 36863704 Free PMC article.
A total of 39 DEGs (18 upregulated and 21 downregulated) were identified in the current study. Four upregulated DEGs, including MNS1, FRZB, OGN, and LUM, and four downregulated DEGs, SERP1NA3, RNASE2, FCN3 and SLCO4A1, were identified by the random forest model. ...Meanwhi …
A total of 39 DEGs (18 upregulated and 21 downregulated) were identified in the current study. Four upregulated DEGs, including MNS1, …
A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans.
Li Y, Wang WL, Tu CF, Meng LL, Hu TY, Du J, Lin G, Nie HC, Tan YQ. Li Y, et al. Asian J Androl. 2021 Mar-Apr;23(2):197-204. doi: 10.4103/aja.aja_56_20. Asian J Androl. 2021. PMID: 33037173 Free PMC article.
Subsequent variant screening identified four additional heterozygous MNS1 variants in 6/219 infertile individuals with oligoasthenospermia, but no MNS1 variants were observed among 223 fertile controls. ...Overall, this is the first study to report a loss-of-functio …
Subsequent variant screening identified four additional heterozygous MNS1 variants in 6/219 infertile individuals with oligoasthenosp …
Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility.
Ta-Shma A, Hjeij R, Perles Z, Dougherty GW, Abu Zahira I, Letteboer SJF, Antony D, Darwish A, Mans DA, Spittler S, Edelbusch C, Cindrić S, Nöthe-Menchen T, Olbrich H, Stuhlmann F, Aprea I, Pennekamp P, Loges NT, Breuer O, Shaag A, Rein AJJT, Gulec EY, Gezdirici A, Abitbul R, Elias N, Amirav I, Schmidts M, Roepman R, Elpeleg O, Omran H. Ta-Shma A, et al. PLoS Genet. 2018 Aug 27;14(8):e1007602. doi: 10.1371/journal.pgen.1007602. eCollection 2018 Aug. PLoS Genet. 2018. PMID: 30148830 Free PMC article.
In-depth ultrastructural analyses confirmed a subtle outer dynein arm (ODA) defect in the axonemes of respiratory epithelial cells resembling findings reported in Mns1-deficient mice. Ultrastructural analyses in the female carrying combined mutations in MNS1 and DNA …
In-depth ultrastructural analyses confirmed a subtle outer dynein arm (ODA) defect in the axonemes of respiratory epithelial cells resemblin …
Knockdown of Mns1 Increases Susceptibility to Craniofacial Defects Following Gastrulation-Stage Alcohol Exposure in Mice.
Boschen KE, Gong H, Murdaugh LB, Parnell SE. Boschen KE, et al. Alcohol Clin Exp Res. 2018 Nov;42(11):2136-2143. doi: 10.1111/acer.13876. Epub 2018 Sep 10. Alcohol Clin Exp Res. 2018. PMID: 30129265 Free PMC article.
While little is known regarding the function or expression pattern of MNS1 in the embryo, co-immunoprecipitation experiments in sperm have determined that MNS1 interacts with ciliary proteins, which are also important during development. ...Furthermore, PAE interact …
While little is known regarding the function or expression pattern of MNS1 in the embryo, co-immunoprecipitation experiments in sperm …
Integrated gene expression profiling analysis reveals SERPINA3, FCN3, FREM1, MNS1 as candidate biomarkers in heart failure and their correlation with immune infiltration.
Jiang Y, Zhang Y, Zhao C. Jiang Y, et al. J Thorac Dis. 2022 Apr;14(4):1106-1119. doi: 10.21037/jtd-22-22. J Thorac Dis. 2022. PMID: 35572891 Free PMC article.
SERPINA3 (area under the curve, AUC =0.958), FCN3 (AUC =0.972), FREM1 (AUC =0.954), and MNS1 (AUC =0.948) were identified as diagnostic factors of HF. The gene set differentiation analysis (GSVA) (R package "GSVA") results showed that the high expression of FREM1 and MN
SERPINA3 (area under the curve, AUC =0.958), FCN3 (AUC =0.972), FREM1 (AUC =0.954), and MNS1 (AUC =0.948) were identified as diagnost …
Heterologous expression and biochemical characterization of an alpha1,2-mannosidase encoded by the Candida albicans MNS1 gene.
Mora-Montes HM, López-Romero E, Zinker S, Ponce-Noyola P, Flores-Carreón A. Mora-Montes HM, et al. Mem Inst Oswaldo Cruz. 2008 Nov;103(7):724-30. doi: 10.1590/s0074-02762008000700016. Mem Inst Oswaldo Cruz. 2008. PMID: 19057825 Free article.
In order to characterise its activity, we first cloned the C. albicans MNS1 gene into Escherichia coli, then expressed and purified the enzyme. ...Polyclonal antibodies specifically raised against recombinant Mns1 also immunoreacted with the soluble alpha1,2-mannosi …
In order to characterise its activity, we first cloned the C. albicans MNS1 gene into Escherichia coli, then expressed and purified t …
Mitochondrial fusion protein MFN2 interacts with the mitostatin-related protein MNS1 required for mouse sperm flagellar structure and function.
Vadnais ML, Lin AM, Gerton GL. Vadnais ML, et al. Cilia. 2014 May 29;3:5. doi: 10.1186/2046-2530-3-5. eCollection 2014. Cilia. 2014. PMID: 24876927 Free PMC article.
Co-immunoprecipitation demonstrated an association between MFN2 and MNS1 in spermatogenic cells. Indirect immunofluorescence indicated that MFN2 and MNS1 co-localized to the sperm flagellum in freshly collected cauda epididymal sperm. ...In spermatogenic cells, MFN2 …
Co-immunoprecipitation demonstrated an association between MFN2 and MNS1 in spermatogenic cells. Indirect immunofluorescence indicate …
63 results