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Identification of host regulators of Mycobacterium tuberculosis phenotypes uncovers a role for the MMGT1-GPR156 lipid droplet axis in persistence.
Kalam H, Chou CH, Kadoki M, Graham DB, Deguine J, Hung DT, Xavier RJ. Kalam H, et al. Cell Host Microbe. 2023 Jun 14;31(6):978-992.e5. doi: 10.1016/j.chom.2023.05.009. Epub 2023 Jun 2. Cell Host Microbe. 2023. PMID: 37269834
We validated hits in a phenotype-specific manner and prioritized membrane magnesium transporter 1 (MMGT1) for a detailed mechanistic investigation. Mtb infection of MMGT1-deficient macrophages promoted a switch to persistence, upregulated lipid metabolism genes, and …
We validated hits in a phenotype-specific manner and prioritized membrane magnesium transporter 1 (MMGT1) for a detailed mechanistic …
Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2.
Goytain A, Quamme GA. Goytain A, et al. Am J Physiol Cell Physiol. 2008 Feb;294(2):C495-502. doi: 10.1152/ajpcell.00238.2007. Epub 2007 Dec 5. Am J Physiol Cell Physiol. 2008. PMID: 18057121 Free article.
Interestingly, MMgT1-HA and MMgT2-V5 were found in separate populations of post-Golgi vesicles. MMgT1 and MMgT2 mRNA increased by about threefold, respectively, in kidney epithelial cells cultured in low-magnesium media relative to normal media and in the kidney cor …
Interestingly, MMgT1-HA and MMgT2-V5 were found in separate populations of post-Golgi vesicles. MMgT1 and MMgT2 mRNA increased …
Magnesium Supplementation Attenuates Pulmonary Hypertension via Regulation of Magnesium Transporters.
Wang D, Zhu ZL, Lin DC, Zheng SY, Chuang KH, Gui LX, Yao RH, Zhu WJ, Sham JSK, Lin MJ. Wang D, et al. Hypertension. 2021 Feb;77(2):617-631. doi: 10.1161/HYPERTENSIONAHA.120.14909. Epub 2020 Dec 28. Hypertension. 2021. PMID: 33356397
It was associated with a reduction of [Mg(2+)](i) in PASMCs, a significant increase in gene expressions of Cnnm2, Hip14, Hip14l, Magt1, Mmgt1, Mrs2, Nipa1, Nipa2, Slc41a1, Slc41a2 and Trpm7; upregulation of SLC41A1, SLC41A2, CNNM2, and TRPM7 proteins; and downregulation of …
It was associated with a reduction of [Mg(2+)](i) in PASMCs, a significant increase in gene expressions of Cnnm2, Hip14, Hip14l, Magt1, M …
Generation and characterization of mouse microglial cell lines.
Briers TW, Desmaretz C, Vanmechelen E. Briers TW, et al. J Neuroimmunol. 1994 Jul;52(2):153-64. doi: 10.1016/0165-5728(94)90109-0. J Neuroimmunol. 1994. PMID: 8034755
A murine cell line (MMGT1) has been established after transfection of primary microglial cell cultures with a v-myc-containing plasmid. This cell line was comparable with primary microglial cells with respect to morphology, presence of acetylated low density lipoprotein re …
A murine cell line (MMGT1) has been established after transfection of primary microglial cell cultures with a v-myc-containing plasmi …