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Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.
Akintayo A, Mayoral J, Asada M, Tang J, Sundaram S, Stanley P. Akintayo A, et al. J Biol Chem. 2020 Oct 9;295(41):14053-14064. doi: 10.1074/jbc.RA120.014784. Epub 2020 Aug 6. J Biol Chem. 2020. PMID: 32763972 Free PMC article.
The membrane-bound, long form of MGAT4D, termed MGAT4D-L, inhibits MGAT1 activity in transfected cells and reduces the generation of complex N-glycans. ...Nevertheless, mutant, inactive MGAT4D-L interacted with MGAT1 in co-immuno-precipitation experiments. .. …
The membrane-bound, long form of MGAT4D, termed MGAT4D-L, inhibits MGAT1 activity in transfected cells and reduces the generat …
The Golgi Glycoprotein MGAT4D is an Intrinsic Protector of Testicular Germ Cells From Mild Heat Stress.
Akintayo A, Liang M, Bartholdy B, Batista F, Aguilan J, Prendergast J, Sabrin A, Sundaram S, Stanley P. Akintayo A, et al. Sci Rep. 2020 Feb 7;10(1):2135. doi: 10.1038/s41598-020-58923-6. Sci Rep. 2020. PMID: 32034218 Free PMC article.
Here, we identify the germ cell specific Golgi glycoprotein MGAT4D as a protector of male germ cells from heat stress. Mgat4d is highly expressed in spermatocytes and spermatids. ...Thus, the Golgi glycoprotein MGAT4D is a novel, intrinsic protector of male g …
Here, we identify the germ cell specific Golgi glycoprotein MGAT4D as a protector of male germ cells from heat stress. Mgat4d …
GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain.
Huang HH, Hassinen A, Sundaram S, Spiess AN, Kellokumpu S, Stanley P. Huang HH, et al. Elife. 2015 Sep 15;4:e08916. doi: 10.7554/eLife.08916. Elife. 2015. PMID: 26371870 Free PMC article.
Mouse GnT1IP-L, and membrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synthesis of hybrid and complex N-glycans. ...GnT1IP-L did not generate a FRET signal with MGAT2, MGAT3, MGAT4B or MGAT5 m …
Mouse GnT1IP-L, and membrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase t …
Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study.
Li C, He J, Chen J, Zhao J, Gu D, Hixson JE, Rao DC, Jaquish CE, Gu CC, Chen J, Huang J, Chen S, Kelly TN. Li C, et al. Hypertension. 2016 Aug;68(2):348-55. doi: 10.1161/HYPERTENSIONAHA.115.06765. Epub 2016 Jun 6. Hypertension. 2016. PMID: 27271309 Free PMC article.
Genome-wide gene-based analysis identified MKNK1 (P=6.7010(-7)), C2orf80 (P<1.0010(-12)), EPHA6 (P=2.8810(-7)), SCOC-AS1 (P=4.3510(-14)), SCOC (P=6.4610(-11)), CLGN (P=3.6810(-13)), MGAT4D (P=4.7310(-11)), ARHGAP42 (P1.0010(-12)), CASP4 (P=1.3110(-8)), and LINC01478 (P= …
Genome-wide gene-based analysis identified MKNK1 (P=6.7010(-7)), C2orf80 (P<1.0010(-12)), EPHA6 (P=2.8810(-7)), SCOC-AS1 (P=4.3510(-14)), …