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Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation.
Choi YJ, Yoo JS, Jung K, Rice L, Kim D, Zlojutro V, Frimel M, Madden E, Choi UY, Foo SS, Choi Y, Jiang Z, Johnson H, Kwak MJ, Kang S, Hong B, Seo GJ, Kim S, Lee SA, Amini-Bavil-Olyaee S, Maazi H, Akbari O, Asosingh K, Jung JU. Choi YJ, et al. Nat Commun. 2023 Apr 11;14(1):2045. doi: 10.1038/s41467-023-37873-3. Nat Commun. 2023. PMID: 37041174 Free PMC article.
Mcemp1-deficient mice exhibit reduced airway inflammation and lung impairment in chronic asthma mouse models. This study shows lung-specific MCEMP1 as an adaptor for KIT to facilitate SCF-mediated mast cell proliferation....
Mcemp1-deficient mice exhibit reduced airway inflammation and lung impairment in chronic asthma mouse models. This study shows lung-s …
Early peripheral blood MCEMP1 and HLA-DRA expression predicts COVID-19 prognosis.
Chan KR, Koh CWT, Ng DHL, Qin S, Ooi JSG, Ong EZ, Zhang SLX, Sam H, Kalimuddin S, Low JGH, Ooi EE. Chan KR, et al. EBioMedicine. 2023 Mar;89:104472. doi: 10.1016/j.ebiom.2023.104472. Epub 2023 Feb 16. EBioMedicine. 2023. PMID: 36801619 Free PMC article.
FINDINGS: The most consistent differentially regulated genes in peripheral blood of severe COVID-19 patients were MCEMP1, HLA-DRA and ETS1 across the 7 transcriptomics datasets. Moreover, we found significantly heightened MCEMP1 and reduced HLA-DRA expression as ear …
FINDINGS: The most consistent differentially regulated genes in peripheral blood of severe COVID-19 patients were MCEMP1, HLA-DRA and …
MCEMP1 is a potential therapeutic biomarker associated with immune infiltration in advanced gastric cancer microenvironment.
Wang D, Gu Y, Huo C, Zhao Y, Teng M, Li Y. Wang D, et al. Gene. 2022 Oct 5;840:146760. doi: 10.1016/j.gene.2022.146760. Epub 2022 Jul 26. Gene. 2022. PMID: 35905854
The expression of MCEMP1 was evaluated by immunohistochemistry (IHC) and quantitative real time PCR. ...GSEA analysis revealed that MCEMP1 was involved in the immune-related signaling pathways. We further demonstrated that the expression of MCEMP1 was correla …
The expression of MCEMP1 was evaluated by immunohistochemistry (IHC) and quantitative real time PCR. ...GSEA analysis revealed that …
Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFbeta dependent manner.
Perrot CY, Karampitsakos T, Unterman A, Adams T, Marlin K, Arsenault A, Zhao A, Kaminski N, Katlaps G, Patel K, Bandyopadhyay D, Herazo-Maya JD. Perrot CY, et al. bioRxiv [Preprint]. 2023 Oct 10:2023.10.07.561349. doi: 10.1101/2023.10.07.561349. bioRxiv. 2023. PMID: 37873485 Free PMC article. Updated. Preprint.
MCEMP1 was upregulated by TGFbeta at the mRNA and protein levels in THP-1. TGFbeta-mediated MCEMP1 upregulation results from the cooperation of SMAD3 and SP1 via concomitant binding to SMAD3/SP1 cis -regulatory elements within the MCEMP1 promoter. ...
MCEMP1 was upregulated by TGFbeta at the mRNA and protein levels in THP-1. TGFbeta-mediated MCEMP1 upregulation results from t …
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.
Raman K, O'Donnell MJ, Czlonkowska A, Duarte YC, Lopez-Jaramillo P, Peñaherrera E, Sharma M, Shoamanesh A, Skowronska M, Yusuf S, Paré G. Raman K, et al. Stroke. 2016 Mar;47(3):652-8. doi: 10.1161/STROKEAHA.115.011854. Epub 2016 Feb 4. Stroke. 2016. PMID: 26846866
MCEMP1 increased by 2.4-fold in stroke when compared with controls (95% confidence interval, 2.0-2.8; P=8.210(-22)). ...Furthermore, MCEMP1 expression independently improved discrimination of 1-month outcome. ...
MCEMP1 increased by 2.4-fold in stroke when compared with controls (95% confidence interval, 2.0-2.8; P=8.210(-22)). ...Furthermore, …
The Expression, Prognostic Value, and Immunological Correlation of MCEMP1 and its Potential Role in Gastric Cancer.
Huang P, Liu Y, Jia B. Huang P, et al. J Oncol. 2022 Mar 26;2022:8167496. doi: 10.1155/2022/8167496. eCollection 2022. J Oncol. 2022. PMID: 35378772 Free PMC article.
METHODS: The expression of MCEMP1 was assessed through public databases. The GO, KEGG, and GESA analyses were conducted to explore the biofunction of MCEMP1. ...CONCLUSION: MCEMP1 shows a potential value for the prognosis in GC. And, abnormal expression of …
METHODS: The expression of MCEMP1 was assessed through public databases. The GO, KEGG, and GESA analyses were conducted to explore th …
Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study.
Kong C, Zhu Y, Xie X, Wu J, Qian M. Kong C, et al. Front Immunol. 2023 Jun 8;14:1184700. doi: 10.3389/fimmu.2023.1184700. eCollection 2023. Front Immunol. 2023. PMID: 37359526 Free PMC article.
With the use of Lasso regression and Boruta feature selection algorithm, six hub genes (CD177, CLEC5A, CYSTM1, MCEMP1, MMP8, and RGL4) with expression differences in septic shock were screened as potential diagnostic markers for septic shock among the significant DEGs and …
With the use of Lasso regression and Boruta feature selection algorithm, six hub genes (CD177, CLEC5A, CYSTM1, MCEMP1, MMP8, and RGL4 …
Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner.
Perrot CY, Karampitsakos T, Unterman A, Adams T, Marlin K, Arsenault A, Zhao A, Kaminski N, Katlaps G, Patel K, Bandyopadhyay D, Herazo-Maya JD. Perrot CY, et al. Am J Physiol Cell Physiol. 2024 Mar 1;326(3):C964-C977. doi: 10.1152/ajpcell.00563.2023. Epub 2024 Jan 8. Am J Physiol Cell Physiol. 2024. PMID: 38189137 Free article.
Here we aimed to establish the mechanistic role of MCEMP1 in pulmonary fibrosis. We identified increased MCEMP1 expression in classical monocytes and alveolar macrophages in IPF compared with controls. ...TGFbeta-mediated MCEMP1 upregulation results from the …
Here we aimed to establish the mechanistic role of MCEMP1 in pulmonary fibrosis. We identified increased MCEMP1 expression in …
35 results