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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1994 3
1995 2
1996 8
1997 6
1998 12
1999 16
2000 14
2001 29
2002 37
2003 37
2004 32
2005 24
2006 24
2007 35
2008 34
2009 31
2010 38
2011 50
2012 53
2013 44
2014 45
2015 42
2016 48
2017 42
2018 27
2019 44
2020 32
2021 34
2022 29
2023 26
2024 10

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814 results

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Page 1
MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome.
Gong KQ, Mikacenic C, Long ME, Frevert CW, Birkland TP, Charron J, Gharib SA, Manicone AM. Gong KQ, et al. Am J Respir Cell Mol Biol. 2022 May;66(5):555-563. doi: 10.1165/rcmb.2021-0252OC. Am J Respir Cell Mol Biol. 2022. PMID: 35157553 Free PMC article.
In preclinical acute lung injury (ALI) models, inhibition of MAP2K1 (MAPK kinase 1)/MAP2K2 (MAPK kinase 2) improves measures of ALI. Myeloid cell deletion of MAP2K1 results in sustained MAP2K2 activation and nonresolving ALI, suggesting that MAP2K2 deactivati …
In preclinical acute lung injury (ALI) models, inhibition of MAP2K1 (MAPK kinase 1)/MAP2K2 (MAPK kinase 2) improves measures of ALI. …
The MAP2K2 Gene as Potential Diagnostic Marker in Monitoring Adalimumab Therapy of Psoriatic Arthritis.
Krawczyk A, Strzałka-Mrozik B, Juszczyk K, Kimsa-Dudek M, Wcisło-Dziadecka D, Gola J. Krawczyk A, et al. Curr Pharm Biotechnol. 2023;24(2):330-340. doi: 10.2174/1389201023666220628111644. Curr Pharm Biotechnol. 2023. PMID: 35762548
Validation of the results confirmed a statistically significant decrease in the transcriptional activity of the MAP2K2 gene in the group of patients three months after the administration of adalimumab relative to the control group. CONCLUSION: Adalimumab therapy alters the …
Validation of the results confirmed a statistically significant decrease in the transcriptional activity of the MAP2K2 gene in the gr …
YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.
Hua Z, Wei R, Guo M, Lin Z, Yu X, Li X, Gu C, Yang Y. Hua Z, et al. Oncogene. 2022 Mar;41(10):1482-1491. doi: 10.1038/s41388-022-02191-3. Epub 2022 Jan 24. Oncogene. 2022. PMID: 35075244
ChIP-seq and PCR assays revealed that STAT5A suppressed MM cell proliferation by occupying the transcription site of MAP2K2 to decrease ERK phosphorylation. In addition, we confirmed that YTHDF2 mediated the unphosphorylated form of STAT5A to inhibit the expression of M …
ChIP-seq and PCR assays revealed that STAT5A suppressed MM cell proliferation by occupying the transcription site of MAP2K2 to decrea …
Multiple cafe au lait spots in familial patients with MAP2K2 mutation.
Takenouchi T, Shimizu A, Torii C, Kosaki R, Takahashi T, Saya H, Kosaki K. Takenouchi T, et al. Am J Med Genet A. 2014 Feb;164A(2):392-6. doi: 10.1002/ajmg.a.36288. Epub 2013 Dec 5. Am J Med Genet A. 2014. PMID: 24311457 Review.
Here, we report familial patients with multiple cafe au lait spots and Noonan syndrome-like facial features. A mutation analysis unexpectedly revealed a mutation in MAP2K2 in both the propositus and his mother. The propositus fulfilled the diagnostic criteria for neurofibr …
Here, we report familial patients with multiple cafe au lait spots and Noonan syndrome-like facial features. A mutation analysis unexpectedl …
Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation.
Nadeau V, Guillemette S, Bélanger LF, Jacob O, Roy S, Charron J. Nadeau V, et al. Development. 2009 Apr;136(8):1363-74. doi: 10.1242/dev.031872. Development. 2009. PMID: 19304888
In the mouse, loss of Map2k1 function causes embryonic lethality, whereas Map2k2 mutants survive with a normal lifespan, suggesting that Map2k1 masks the phenotype due to the Map2k2 mutation. ...Most Map2k1(+/-)Map2k2(+/-) embryos die during gestation because …
In the mouse, loss of Map2k1 function causes embryonic lethality, whereas Map2k2 mutants survive with a normal lifespan, suggesting t …
Efficacy of MEK inhibition in patients with histiocytic neoplasms.
Diamond EL, Durham BH, Ulaner GA, Drill E, Buthorn J, Ki M, Bitner L, Cho H, Young RJ, Francis JH, Rampal R, Lacouture M, Brody LA, Ozkaya N, Dogan A, Rosen N, Iasonos A, Abdel-Wahab O, Hyman DM. Diamond EL, et al. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13. Nature. 2019. PMID: 30867592 Free PMC article. Clinical Trial.
Cobimetinib treatment was efficacious regardless of genotype, and responses were observed in patients with ARAF, BRAF, RAF1, NRAS, KRAS, MEK1 (also known as MAP2K1) and MEK2 (also known as MAP2K2) mutations. Consistent with the observed responses, the characterization of t …
Cobimetinib treatment was efficacious regardless of genotype, and responses were observed in patients with ARAF, BRAF, RAF1, NRAS, KRAS, MEK …
MAP2K2 mutation as a cause of cardio-facio-cutaneous syndrome in an infant with a severe and fatal course of the disease.
Gos M, Smigiel R, Kaczan T, Landowska A, Abramowicz A, Sasiadek M, Bal J. Gos M, et al. Am J Med Genet A. 2018 Jul;176(7):1670-1674. doi: 10.1002/ajmg.a.38837. Epub 2018 May 25. Am J Med Genet A. 2018. PMID: 29799162
The RASopathy, particularly CFCS, clinical diagnosis was confirmed and de novo p.Phe57Ile mutation in MAP2K2 was identified....
The RASopathy, particularly CFCS, clinical diagnosis was confirmed and de novo p.Phe57Ile mutation in MAP2K2 was identified....
Genistein suppresses allergic contact dermatitis through regulating the MAP2K2/ERK pathway.
Xu J , Xiong H , Zhao Z , Luo M , Ju Y , Yang G , Mei Z . Xu J , et al. Food Funct. 2021 May 21;12(10):4556-4569. doi: 10.1039/d0fo03238g. Epub 2021 Apr 27. Food Funct. 2021. PMID: 33908440
Altogether, our findings demonstrated that genistein exhibits strong antipruritic and anti-inflammatory effects in ACD mice by inhibiting the production of pro-inflammatory cytokines and intracellular MAP2K2/ERK cell signaling, which makes genistein a potentially valuable …
Altogether, our findings demonstrated that genistein exhibits strong antipruritic and anti-inflammatory effects in ACD mice by inhibiting th …
Selumetinib: First Approval.
Markham A, Keam SJ. Markham A, et al. Drugs. 2020 Jun;80(9):931-937. doi: 10.1007/s40265-020-01331-x. Drugs. 2020. PMID: 32504375 Review.
814 results