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Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer's and Parkinson's Diseases.
Mayo S, Benito-León J, Peña-Bautista C, Baquero M, Cháfer-Pericás C. Mayo S, et al. Curr Neuropharmacol. 2021;19(8):1273-1303. doi: 10.2174/1570159X19666201223154009. Curr Neuropharmacol. 2021. PMID: 33357195 Free PMC article. Review.
In addition, DNA methylation has been tested in a few works, obtaining significant differences in some genes (NCAPH2/LMF2 COASY, SPINT1, BDNFTREM1, TREM2, NPAS2, PDE4D), which could be useful for evaluating the disease progression as well as potential risk factors. ...
In addition, DNA methylation has been tested in a few works, obtaining significant differences in some genes (NCAPH2/LMF2 COASY, SPIN …
DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer's disease and amnesic mild cognitive impairment patients.
Shinagawa S, Kobayashi N, Nagata T, Kusaka A, Yamada H, Kondo K, Nakayama K. Shinagawa S, et al. Neurosci Lett. 2016 Aug 26;629:33-37. doi: 10.1016/j.neulet.2016.06.055. Epub 2016 Jun 26. Neurosci Lett. 2016. PMID: 27356276
However, there is still uncertainty about the mechanism by which NCAPH2/LMF2 methylation affects the pathogenesis of AD and aMCI. In this study, we investigated relationships between NCAPH2/LMF2 methylation and other factors. ...Regression analysis revealed that onl …
However, there is still uncertainty about the mechanism by which NCAPH2/LMF2 methylation affects the pathogenesis of AD and aMCI. In …
Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank.
Park J, MacLean MT, Lucas AM, Torigian DA, Schneider CV, Cherlin T, Xiao B, Miller JE, Bradford Y, Judy RL; Regeneron Genetics Center; Verma A, Damrauer SM, Ritchie MD, Witschey WR, Rader DJ. Park J, et al. Cell Rep Med. 2022 Dec 20;3(12):100855. doi: 10.1016/j.xcrm.2022.100855. Epub 2022 Dec 12. Cell Rep Med. 2022. PMID: 36513072 Free PMC article.
We confirm single variants previously associated with hepatic fat and identify several additional variants, including two (FGD5 H600Y and CITED2 S198_G199del) that replicated in UKB. A burden of rare pLOF variants in LMF2 is associated with increased hepatic fat and replic …
We confirm single variants previously associated with hepatic fat and identify several additional variants, including two (FGD5 H600Y and CI …
Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment.
Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K. Kobayashi N, et al. PLoS One. 2016 Jan 7;11(1):e0146449. doi: 10.1371/journal.pone.0146449. eCollection 2016. PLoS One. 2016. PMID: 26742120 Free PMC article.

For confirmation, we increased group sizes and examined samples by pyrosequencing which revealed that DNA methylation in the NCAPH2/LMF2 promoter region was significantly decreased in the AD (n = 30) and aMCI (n = 28) groups as compared to the NC group (n = 30) (P < 0.0

…
For confirmation, we increased group sizes and examined samples by pyrosequencing which revealed that DNA methylation in the NCAPH2/LMF2 …
Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice.
Kim YI, Oh WS, Song PH, Yun S, Kwon YS, Lee YJ, Ku SK, Song CH, Oh TH. Kim YI, et al. Mar Drugs. 2018 Aug 18;16(8):286. doi: 10.3390/md16080286. Mar Drugs. 2018. PMID: 30126169 Free PMC article.
A UVB-irradiated mouse model was topically treated with myricetin or LMF at 2.0, 1.0 and 0.2 mg/cm2 (LMF2.0, LMF1.0 and LMF0.2, respectively) once a day for 15 weeks. Wrinkle formation, inflammation, oxidative stress, MMP expression, and apoptosis in the treated regions we …
A UVB-irradiated mouse model was topically treated with myricetin or LMF at 2.0, 1.0 and 0.2 mg/cm2 (LMF2.0, LMF1.0 and LMF0.2, respe …
Silencing of a lipase maturation factor 2-like gene by wheat-mediated RNAi reduces the survivability and reproductive capacity of the grain aphid, Sitobion avenae.
Xu L, Hou Q, Zhao Y, Lu L, Li B, Ni Z, Liang R. Xu L, et al. Arch Insect Biochem Physiol. 2017 Jul;95(3). doi: 10.1002/arch.21392. Epub 2017 Jun 15. Arch Insect Biochem Physiol. 2017. PMID: 28618004
Lipase maturation factor (LMF) family proteins are required for the maturation and transport of active lipoprotein lipases. However, the specific roles of LMF2 remain unknown. In this study, a grain aphid lmf2-like gene fragment was cloned and was highly similar in …
Lipase maturation factor (LMF) family proteins are required for the maturation and transport of active lipoprotein lipases. However, the spe …
Genomic Landscape of Copy Number Variations and Their Associations with Climatic Variables in the World's Sheep.
Salehian-Dehkordi H, Huang JH, Pirany N, Mehrban H, Lv XY, Sun W, Esmailizadeh A, Lv FH. Salehian-Dehkordi H, et al. Genes (Basel). 2023 Jun 13;14(6):1256. doi: 10.3390/genes14061256. Genes (Basel). 2023. PMID: 37372436 Free PMC article.
., HTT), GTPase activity (e.g., COPG), fast metabolism (e.g., LMF2 and LPIN3), fertility and reproduction (e.g., SLC19A1 and CCDC155), growth-related traits (e.g., ADRM1 and IGFALS), and immune response (e.g., BEGAIN and RNF121) in sheep. ...
., HTT), GTPase activity (e.g., COPG), fast metabolism (e.g., LMF2 and LPIN3), fertility and reproduction (e.g., SLC19A1 and CCDC155) …