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270 results

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Page 1
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.
Tanaka T, Warner BM, Michael DG, Nakamura H, Odani T, Yin H, Atsumi T, Noguchi M, Chiorini JA. Tanaka T, et al. Autophagy. 2022 Jul;18(7):1629-1647. doi: 10.1080/15548627.2021.1995150. Epub 2021 Nov 22. Autophagy. 2022. PMID: 34802379 Free PMC article.
A253-control: A253 control for LAMP3 stable overexpression; A253- LAMP3: A253 LAPM3 stable overexpression; CASP1: caspase 1; CASP3: caspase 3; CHX: cycloheximide; CTSB: cathepsin B; CTSD: cathepsin D; CQ: chloroquine; DCs: dendritic cells; ER: endoplasmic reticulum; …
A253-control: A253 control for LAMP3 stable overexpression; A253- LAMP3: A253 LAPM3 stable overexpression; CASP1: caspase 1; C …
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells.
Cheng S, Li Z, Gao R, Xing B, Gao Y, Yang Y, Qin S, Zhang L, Ouyang H, Du P, Jiang L, Zhang B, Yang Y, Wang X, Ren X, Bei JX, Hu X, Bu Z, Ji J, Zhang Z. Cheng S, et al. Cell. 2021 Feb 4;184(3):792-809.e23. doi: 10.1016/j.cell.2021.01.010. Cell. 2021. PMID: 33545035 Free article.
Mast cells in nasopharyngeal cancer were found to be associated with better prognosis and exhibited an anti-tumor phenotype with a high ratio of TNF(+)/VEGFA(+) cells. Systematic comparison between cDC1- and cDC2-derived LAMP3(+) cDCs revealed their differences in transcri …
Mast cells in nasopharyngeal cancer were found to be associated with better prognosis and exhibited an anti-tumor phenotype with a high rati …
Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.
Sun Q, Wang F, Chen Q, Sarid R, Li X, Kuang E. Sun Q, et al. J Virol. 2022 Dec 14;96(23):e0145622. doi: 10.1128/jvi.01456-22. Epub 2022 Nov 15. J Virol. 2022. PMID: 36377873 Free PMC article.
Furthermore, ATF4 enhances lytic replication through LAMP3, and LAMP3 acts in an ATF4-independent manner. Our findings suggest that the ATF4-LAMP3 axis is upregulated by ORF45 through ER stress activation during the KSHV lytic life cycle and, in turn, facilit …
Furthermore, ATF4 enhances lytic replication through LAMP3, and LAMP3 acts in an ATF4-independent manner. Our findings suggest …
A pan-cancer single-cell panorama of human natural killer cells.
Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L, Peng H, Wang D, Zhang Z. Tang F, et al. Cell. 2023 Sep 14;186(19):4235-4251.e20. doi: 10.1016/j.cell.2023.07.034. Epub 2023 Aug 21. Cell. 2023. PMID: 37607536 Free article.
Notably, we have identified a group of tumor-associated NK cells that are enriched in tumors, show impaired anti-tumor functions, and are associated with unfavorable prognosis and resistance to immunotherapy. Specific myeloid cell subpopulations, in particular LAMP3(+) den …
Notably, we have identified a group of tumor-associated NK cells that are enriched in tumors, show impaired anti-tumor functions, and are as …
LAMP3 deficiency affects surfactant homeostasis in mice.
Lunding LP, Krause D, Stichtenoth G, Stamme C, Lauterbach N, Hegermann J, Ochs M, Schuster B, Sedlacek R, Saftig P, Schwudke D, Wegmann M, Damme M. Lunding LP, et al. PLoS Genet. 2021 Jun 23;17(6):e1009619. doi: 10.1371/journal.pgen.1009619. eCollection 2021 Jun. PLoS Genet. 2021. PMID: 34161347 Free PMC article.
The physiological function of LAMP3, however, remains enigmatic. We generated Lamp3 knockout mice by CRISPR/Cas9. LAMP3 deficient mice are viable with an average life span and display regular lung function under basal conditions. ...
The physiological function of LAMP3, however, remains enigmatic. We generated Lamp3 knockout mice by CRISPR/Cas9. LAMP3 …
LAMP3 transfer via extracellular particles induces apoptosis in Sjogren's disease.
Tanaka T, Nakamura H, Tran DT, Warner BM, Wang Y, Atsumi T, Noguchi M, Chiorini JA. Tanaka T, et al. Sci Rep. 2023 Feb 14;13(1):2595. doi: 10.1038/s41598-023-28857-w. Sci Rep. 2023. PMID: 36788255 Free PMC article.
Proteomics identified LAMP3 as a major component of EPs derived from LAMP3-overexpressing cells. Live-cell imaging visualized release and uptake of LAMP3-containing EPs from LAMP3-overexpressing cells to naive cells. ...
Proteomics identified LAMP3 as a major component of EPs derived from LAMP3-overexpressing cells. Live-cell imaging visualized …
Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma.
Zhang Q, He Y, Luo N, Patel SJ, Han Y, Gao R, Modak M, Carotta S, Haslinger C, Kind D, Peet GW, Zhong G, Lu S, Zhu W, Mao Y, Xiao M, Bergmann M, Hu X, Kerkar SP, Vogt AB, Pflanz S, Liu K, Peng J, Ren X, Zhang Z. Zhang Q, et al. Cell. 2019 Oct 31;179(4):829-845.e20. doi: 10.1016/j.cell.2019.10.003. Cell. 2019. PMID: 31675496 Free article.
Combining two single-cell RNA sequencing technologies, we produced transcriptomes of CD45(+) immune cells for HCC patients from five immune-relevant sites: tumor, adjacent liver, hepatic lymph node (LN), blood, and ascites. A cluster of LAMP3(+) dendritic cells (DCs) appea …
Combining two single-cell RNA sequencing technologies, we produced transcriptomes of CD45(+) immune cells for HCC patients from five immune- …
Interactions of Indoleamine 2,3-dioxygenase-expressing LAMP3(+) dendritic cells with CD4(+) regulatory T cells and CD8(+) exhausted T cells: synergistically remodeling of the immunosuppressive microenvironment in cervical cancer and therapeutic implications.
Qu X, Wang Y, Jiang Q, Ren T, Guo C, Hua K, Qiu J. Qu X, et al. Cancer Commun (Lond). 2023 Nov;43(11):1207-1228. doi: 10.1002/cac2.12486. Epub 2023 Oct 4. Cancer Commun (Lond). 2023. PMID: 37794698 Free PMC article.
RESULTS: Malignant cervical epithelial cells did not manifest noticeable signs of tumor escape, whereas lysosomal-associated membrane protein 3-positive (LAMP3(+) ) dendritic cells (DCs) in a mature state with immunoregulatory roles were found to express IDO1 and affect tr …
RESULTS: Malignant cervical epithelial cells did not manifest noticeable signs of tumor escape, whereas lysosomal-associated membrane protei …
LAMP3 expression in the liver is involved in T cell activation and adaptive immune regulation in hepatitis B virus infection.
Wang Z, Wang X, Jin R, Liu F, Rao H, Wei L, Chen H, Feng B. Wang Z, et al. Front Immunol. 2023 Mar 16;14:1127572. doi: 10.3389/fimmu.2023.1127572. eCollection 2023. Front Immunol. 2023. PMID: 37006307 Free PMC article.
Differentially expressed genes were obtained from one CHB cohort by comparing LAMP3(high) and LAMP3(low) expression subgroups. These genes underwent Gene Ontology, Kyoto Encyclopedia of Genes and Genomes analysis, and Gene Set Enrichment Analysis to decipher the inf …
Differentially expressed genes were obtained from one CHB cohort by comparing LAMP3(high) and LAMP3(low) expression subgroups. …
LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection.
Nazli A, Chow R, Zahoor MA, Workenhe ST, Dhawan T, Verschoor C, Kaushic C. Nazli A, et al. J Virol. 2022 Dec 14;96(23):e0155322. doi: 10.1128/jvi.01553-22. Epub 2022 Nov 9. J Virol. 2022. PMID: 36350153 Free PMC article.
Consequently, we generated two gene-altered VK2-derived cell lines, a LAMP3-overexpressed (OE) line and a LAMP3 knockout (KO) line. The wild-type VK2 and the LAMP3 OE and KO cell lines were grown in air-liquid interface (ALI) cultures for 7 days and infected …
Consequently, we generated two gene-altered VK2-derived cell lines, a LAMP3-overexpressed (OE) line and a LAMP3 knockout (KO) …
270 results