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EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells.
Yadav P, Ahmed T, Park S, Sidler M, Schröder A, Aitken KJ, Bägli D. Yadav P, et al. Am J Clin Exp Urol. 2023 Aug 15;11(4):293-303. eCollection 2023. Am J Clin Exp Urol. 2023. PMID: 37645613 Free PMC article.
Cells were analyzed by immunostaining for cell phenotype, and western blotting for KCNB2, H3K27me3 and EZH2. Effects of conditioned media from these cells were also examined on cell phenotype. siRNA against KCNB2 was examined for effects on cell phenotype and gene e …
Cells were analyzed by immunostaining for cell phenotype, and western blotting for KCNB2, H3K27me3 and EZH2. Effects of conditioned m …
Genetic contribution to PONV risk.
Klenke S, de Vries GJ, Schiefer L, Seyffert N, Bachmann HS, Peters J, Frey UH. Klenke S, et al. Anaesth Crit Care Pain Med. 2020 Feb;39(1):45-51. doi: 10.1016/j.accpm.2019.04.012. Epub 2019 May 8. Anaesth Crit Care Pain Med. 2020. PMID: 31077873
RESULTS: Early PONV occurred in 37%. There was a significant association of the KCNB2 rs349358 SNP with nausea (P = 0.021), retching (P = 0.001), and PONV (P = 0.006). The rs349358 genotype distribution was TT in 310 and TC/CC in 155 patients. The KCNB2 SNP was asso …
RESULTS: Early PONV occurred in 37%. There was a significant association of the KCNB2 rs349358 SNP with nausea (P = 0.021), retching …
Mono-allelic KCNB2 variants lead to a neurodevelopmental syndrome caused by altered channel inactivation.
Bhat S, Rousseau J, Michaud C, Lourenço CM, Stoler JM, Louie RJ, Clarkson LK, Lichty A, Koboldt DC, Reshmi SC, Sisodiya SM, Hoytema van Konijnenburg EMM, Koop K, van Hasselt PM, Démurger F, Dubourg C, Sullivan BR, Hughes SS, Thiffault I, Tremblay ES, Accogli A, Srour M, Blunck R, Campeau PM. Bhat S, et al. Am J Hum Genet. 2024 Apr 4;111(4):761-777. doi: 10.1016/j.ajhg.2024.02.014. Epub 2024 Mar 18. Am J Hum Genet. 2024. PMID: 38503299
The KCNB family of voltage-gated potassium channels (Kv) consists of two members (KCNB1 and KCNB2) encoded by KCNB1 and KCNB2, respectively. These channels are major contributors to delayed rectifier potassium currents arising from the neuronal soma which modulate o …
The KCNB family of voltage-gated potassium channels (Kv) consists of two members (KCNB1 and KCNB2) encoded by KCNB1 and KCNB2, …
MicroRNA-1 accelerates the shortening of atrial effective refractory period by regulating KCNE1 and KCNB2 expression: an atrial tachypacing rabbit model.
Jia X, Zheng S, Xie X, Zhang Y, Wang W, Wang Z, Zhang Y, Wang J, Gao M, Hou Y. Jia X, et al. PLoS One. 2013 Dec 30;8(12):e85639. doi: 10.1371/journal.pone.0085639. eCollection 2013. PLoS One. 2013. PMID: 24386485 Free PMC article.
The downregulation of KCNE1 and KCNB2 levels was greater when miR-1 was further upregulated through in vivo lentiviral infection. ...Conversely, knockdown of miR-1 by anti-miR-1 inhibitor oligonucleotides alleviated the downregulation of KCNE1 and KCNB2, the shorten …
The downregulation of KCNE1 and KCNB2 levels was greater when miR-1 was further upregulated through in vivo lentiviral infection. ... …
KvS regulatory subunits confer drug resistance to Kv2 channels.
Stewart RG, Marquis MJ, Jo S, Ferns M, Sack JT. Stewart RG, et al. bioRxiv [Preprint]. 2024 Feb 2:2024.01.31.578214. doi: 10.1101/2024.01.31.578214. bioRxiv. 2024. PMID: 38352561 Free PMC article. Preprint.
KvS proteins are pore-forming voltage-gated potassium channel subunits that must co-assemble into heterotetramers with Kv2.1 ( KCNB1 ) or Kv2.2 ( KCNB2 ) subunits to form functional channels. In mammals, KvS subunits encompass the Kv5.1 ( KCNF1 ), Kv6.1 ( KCNG1 ), Kv6.2 ( …
KvS proteins are pore-forming voltage-gated potassium channel subunits that must co-assemble into heterotetramers with Kv2.1 ( KCNB1 ) or Kv …
Genetic variability in postoperative nausea and vomiting: A systematic review.
Klenke S, Frey UH. Klenke S, et al. Eur J Anaesthesiol. 2020 Nov;37(11):959-968. doi: 10.1097/EJA.0000000000001224. Eur J Anaesthesiol. 2020. PMID: 32371828
Furthermore, the anaesthesia regimen and the postoperative time point at which the association with PONV was reported were quite different. Only two polymorphisms, the CHRM3 rs2165870 and the KCNB2 rs349358 (both first associated with PONV in a GWAS), have been significant …
Furthermore, the anaesthesia regimen and the postoperative time point at which the association with PONV was reported were quite different. …
Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.
Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE. Fu J, et al. Diabetes. 2017 Jul;66(7):1890-1900. doi: 10.2337/db16-1170. Epub 2017 Jun 12. Diabetes. 2017. PMID: 28607108 Free PMC article.
In this study, we examine the mechanism by which the voltage-dependent K(+) (Kv) channel Kv2.1 (KCNB1) facilitates depolarization-induced exocytosis in INS 832/13 cells and beta-cells from human donors with and without type 2 diabetes (T2D). We find that Kv2.1, but not Kv2.2 ( …
In this study, we examine the mechanism by which the voltage-dependent K(+) (Kv) channel Kv2.1 (KCNB1) facilitates depolarization-induced ex …
Genome-wide association studies of maximum number of drinks.
Pan Y, Luo X, Liu X, Wu LY, Zhang Q, Wang L, Wang W, Zuo L, Wang KS. Pan Y, et al. J Psychiatr Res. 2013 Nov;47(11):1717-24. doi: 10.1016/j.jpsychires.2013.07.013. Epub 2013 Aug 13. J Psychiatr Res. 2013. PMID: 23953852 Free PMC article.
Furthermore, several SNPs (rs17144687 near DTWD2, rs12108602 near NDST4, and rs2128158 in KCNB2) showed significant associations with MaxDrinks (p < 5 10(-7)) in the meta-analysis. ...
Furthermore, several SNPs (rs17144687 near DTWD2, rs12108602 near NDST4, and rs2128158 in KCNB2) showed significant associations with …
Multiple Selection Signatures in Farmed Atlantic Salmon Adapted to Different Environments Across Hemispheres.
López ME, Linderoth T, Norris A, Lhorente JP, Neira R, Yáñez JM. López ME, et al. Front Genet. 2019 Oct 1;10:901. doi: 10.3389/fgene.2019.00901. eCollection 2019. Front Genet. 2019. PMID: 31632437 Free PMC article.
Several regions were identified for these techniques that harbored genes, such as kind1 and chp2, which have been associated with growth-related traits or the kcnb2 gene related to immune system in Atlantic salmon, making them particularly relevant in the context of aquacu …
Several regions were identified for these techniques that harbored genes, such as kind1 and chp2, which have been associated with growth-rel …
Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.
Martinez-Pinna J, Marroqui L, Hmadcha A, Lopez-Beas J, Soriano S, Villar-Pazos S, Alonso-Magdalena P, Dos Santos RS, Quesada I, Martin F, Soria B, Gustafsson JÅ, Nadal A. Martinez-Pinna J, et al. Diabetologia. 2019 Sep;62(9):1667-1680. doi: 10.1007/s00125-019-4925-y. Epub 2019 Jun 27. Diabetologia. 2019. PMID: 31250031 Free article.
RESULTS: Microarray analysis showed that BPA modulated the expression of 1440 probe sets (1192 upregulated and 248 downregulated genes). Of these, more than 50 genes, including Scn9a, Kcnb2, Kcnma1 and Kcnip1, encoded important Na(+) and K(+) channel subunits. ...
RESULTS: Microarray analysis showed that BPA modulated the expression of 1440 probe sets (1192 upregulated and 248 downregulated genes). Of …
40 results