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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 5
2001 5
2002 4
2003 5
2005 2
2006 3
2007 3
2008 7
2009 7
2010 4
2011 3
2012 6
2013 8
2014 6
2015 10
2016 10
2017 9
2018 9
2019 11
2020 14
2021 13
2022 18
2023 33
2024 9

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185 results

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Page 1
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.
Costa A, Kieffer Y, Scholer-Dahirel A, Pelon F, Bourachot B, Cardon M, Sirven P, Magagna I, Fuhrmann L, Bernard C, Bonneau C, Kondratova M, Kuperstein I, Zinovyev A, Givel AM, Parrini MC, Soumelis V, Vincent-Salomon A, Mechta-Grigoriou F. Costa A, et al. Cancer Cell. 2018 Mar 12;33(3):463-479.e10. doi: 10.1016/j.ccell.2018.01.011. Epub 2018 Feb 15. Cancer Cell. 2018. PMID: 29455927 Free article.
By secreting CXCL12, CAF-S1 attracts CD4(+)CD25(+) T lymphocytes and retains them by OX40L, PD-L2, and JAM2. Moreover, CAF-S1 increases T lymphocyte survival and promotes their differentiation into CD25(High)FOXP3(High), through B7H3, CD73, and DPP4. ...
By secreting CXCL12, CAF-S1 attracts CD4(+)CD25(+) T lymphocytes and retains them by OX40L, PD-L2, and JAM2. Moreover, CAF-S1 increas …
JAM2 predicts a good prognosis and inhibits invasion and migration by suppressing EMT pathway in breast cancer.
Peng Y, Li H, Fu Y, Guo S, Qu C, Zhang Y, Zong B, Liu S. Peng Y, et al. Int Immunopharmacol. 2022 Feb;103:108430. doi: 10.1016/j.intimp.2021.108430. Epub 2021 Dec 17. Int Immunopharmacol. 2022. PMID: 34923424
These findings strongly suggest that JAM2 may be a potential oncogene suppressor in breast cancer. However, the role and function of JAM2 in breast cancer are not yet clear. ...Overexpression of JAM2 can block the invasion and migration of breast cancer cells …
These findings strongly suggest that JAM2 may be a potential oncogene suppressor in breast cancer. However, the role and function of …
Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification.
Schottlaender LV, Abeti R, Jaunmuktane Z, Macmillan C, Chelban V, O'Callaghan B, McKinley J, Maroofian R, Efthymiou S, Athanasiou-Fragkouli A, Forbes R, Soutar MPM, Livingston JH, Kalmar B, Swayne O, Hotton G; SYNAPS Study Group; Pittman A, Mendes de Oliveira JR, de Grandis M, Richard-Loendt A, Launchbury F, Althonayan J, McDonnell G, Carr A, Khan S, Beetz C, Bisgin A, Tug Bozdogan S, Begtrup A, Torti E, Greensmith L, Giunti P, Morrison PJ, Brandner S, Aurrand-Lions M, Houlden H. Schottlaender LV, et al. Am J Hum Genet. 2020 Mar 5;106(3):412-421. doi: 10.1016/j.ajhg.2020.02.007. Am J Hum Genet. 2020. PMID: 32142645 Free PMC article.
We show that JAM2 variants lead to reduction of JAM2 mRNA expression and absence of JAM2 protein in patient's fibroblasts, consistent with a loss-of-function mechanism. We show that the human phenotype is replicated in the jam2 complete knockout mouse …
We show that JAM2 variants lead to reduction of JAM2 mRNA expression and absence of JAM2 protein in patient's fibroblas …
JAM2: A New Culprit at the Pathophysiology of Primary Familial Brain Calcification.
Marinho WLVA, de Oliveira JRM. Marinho WLVA, et al. J Mol Neurosci. 2021 Sep;71(9):1723-1724. doi: 10.1007/s12031-021-01816-8. Epub 2021 Mar 20. J Mol Neurosci. 2021. PMID: 33743113
However, there have been reports of the involvement of additional genes in the autosomal recessive inheritance pattern, such as MYORG and more recently JAM2, suggesting that the deregulation of the neurovascular unit (NVU) is important in the pathogenesis of PFBC. ...A gre …
However, there have been reports of the involvement of additional genes in the autosomal recessive inheritance pattern, such as MYORG and mo …
Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification.
Cen Z, Chen Y, Chen S, Wang H, Yang D, Zhang H, Wu H, Wang L, Tang S, Ye J, Shen J, Wang H, Fu F, Chen X, Xie F, Liu P, Xu X, Cao J, Cai P, Pan Q, Li J, Yang W, Shan PF, Li Y, Liu JY, Zhang B, Luo W. Cen Z, et al. Brain. 2020 Feb 1;143(2):491-502. doi: 10.1093/brain/awz392. Brain. 2020. PMID: 31851307
Using homozygosity mapping and whole genome sequencing, we detected a homozygous frameshift mutation (c.140delT, p.L48*) in the JAM2 gene in a consanguineous family with two affected siblings diagnosed with primary familial brain calcification. ...mutant plasmids. In immun …
Using homozygosity mapping and whole genome sequencing, we detected a homozygous frameshift mutation (c.140delT, p.L48*) in the JAM2 …
JAM2 is a prognostic biomarker and inhibits proliferation, metastasis and epithelial-mesenchymal transition in lung adenocarcinoma.
Dong Y, Zhang J, Xie S, Di S, Fan B, Gong T. Dong Y, et al. J Gene Med. 2024 Feb;26(2):e3679. doi: 10.1002/jgm.3679. J Gene Med. 2024. PMID: 38404047
Furthermore, we established a xenograft model to investigate the in vivo effects of JAM2 on tumorigenesis. RESULTS: Our results revealed a significant downregulation of JAM2 in LUAD, and patients with low JAM2 expression exhibited unfavorable overall survival …
Furthermore, we established a xenograft model to investigate the in vivo effects of JAM2 on tumorigenesis. RESULTS: Our results revea …
JAM2 interacts with alpha4beta1. Facilitation by JAM3.
Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA. Cunningham SA, et al. J Biol Chem. 2002 Aug 2;277(31):27589-92. doi: 10.1074/jbc.C200331200. Epub 2002 Jun 17. J Biol Chem. 2002. PMID: 12070135 Free article.
Intriguingly, the engagement of alpha(4)beta(1) by JAM2 is only enabled following prior adhesion of JAM2 with JAM3 and is not detectable in cells where JAM3 expression is absent. Supporting this observation, we show that neutralizing JAM3 serum and soluble JAM3 ecto …
Intriguingly, the engagement of alpha(4)beta(1) by JAM2 is only enabled following prior adhesion of JAM2 with JAM3 and is not …
Pou4f1-Tbr1 transcriptional cascade controls the formation of Jam2-expressing retinal ganglion cells.
Kiyama T, Altay HY, Badea TC, Mao CA. Kiyama T, et al. Front Ophthalmol (Lausanne). 2023;3:1175568. doi: 10.3389/fopht.2023.1175568. Epub 2023 May 18. Front Ophthalmol (Lausanne). 2023. PMID: 38469155 Free PMC article.
We further found that Tbr1 is essential for the expression of Jam2, and Tbr1 regulates the formation and the dendritic morphogenesis of J-RGCs. ...Using the Cleavage Under Targets and Tagmentation technique, we discovered that Pou4f1 binds to Tbr1 on the evolutionary conse …
We further found that Tbr1 is essential for the expression of Jam2, and Tbr1 regulates the formation and the dendritic morphogenesis …
Regulation of JAM2 Expression in the Lungs of Streptozotocin-Induced Diabetic Mice and Human Pluripotent Stem Cell-Derived Alveolar Organoids.
Rasaei R, Kim E, Kim JY, Na S, Kim JH, Heo J, Shin DM, Choi SS, Hong SH. Rasaei R, et al. Biomedicines. 2020 Sep 11;8(9):346. doi: 10.3390/biomedicines8090346. Biomedicines. 2020. PMID: 32932992 Free PMC article.
The elevated level of JAM2 in HG-treated hPVCs was transcriptionally and epigenetically reversible when HG treatment was removed. We further investigated the expression of JAM2 using in vivo and in vitro hyperglycemic models. Our results showed significant upregulat …
The elevated level of JAM2 in HG-treated hPVCs was transcriptionally and epigenetically reversible when HG treatment was removed. We …
JAM2 variants can be more common in primary familial brain calcification (PFBC) cases than those appear; may be due to a founder mutation.
Khojasteh M, Soleimani P, Ghasemi A, Taghizadeh P, Rohani M, Alavi A. Khojasteh M, et al. Neurol Sci. 2024 Mar 5. doi: 10.1007/s10072-024-07419-6. Online ahead of print. Neurol Sci. 2024. PMID: 38441788
INTRODUCTION: Mutations in JAM2 have been linked to ~ 2% of primary familial brain calcification (PFBC) cases. ...Even though this particular mutation may not be classified as a founder mutation, it does appear to be a hotspot, given that it has been observed in 45% of the …
INTRODUCTION: Mutations in JAM2 have been linked to ~ 2% of primary familial brain calcification (PFBC) cases. ...Even though this pa …
185 results