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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 3
1990 2
1991 4
1992 10
1993 10
1994 19
1995 22
1996 19
1997 26
1998 22
1999 33
2000 23
2001 24
2002 22
2003 20
2004 11
2005 20
2006 14
2007 12
2008 15
2009 15
2010 14
2011 16
2012 17
2013 19
2014 21
2015 20
2016 20
2017 24
2018 21
2019 33
2020 29
2021 36
2022 40
2023 24
2024 11

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640 results

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Page 1
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, Korphaisarn K, Chakravarti D, Chang A, Spring DJ, Chang Q, Zhang J, Maru DM, Maeda DY, Zebala JA, Kopetz S, Wang YA, DePinho RA. Liao W, et al. Cancer Cell. 2019 Apr 15;35(4):559-572.e7. doi: 10.1016/j.ccell.2019.02.008. Epub 2019 Mar 21. Cancer Cell. 2019. PMID: 30905761 Free PMC article.
We demonstrate that KRAS() represses the expression of interferon regulatory factor 2 (IRF2), which in turn directly represses CXCL3 expression. KRAS()-mediated repression of IRF2 results in high expression of CXCL3, which binds to CXCR2 on myeloid-derived suppresso …
We demonstrate that KRAS() represses the expression of interferon regulatory factor 2 (IRF2), which in turn directly represses CXCL3 …
The transcription factor IRF2 drives interferon-mediated CD8(+) T cell exhaustion to restrict anti-tumor immunity.
Lukhele S, Rabbo DA, Guo M, Shen J, Elsaesser HJ, Quevedo R, Carew M, Gadalla R, Snell LM, Mahesh L, Ciudad MT, Snow BE, You-Ten A, Haight J, Wakeham A, Ohashi PS, Mak TW, Cui W, McGaha TL, Brooks DG. Lukhele S, et al. Immunity. 2022 Dec 13;55(12):2369-2385.e10. doi: 10.1016/j.immuni.2022.10.020. Epub 2022 Nov 11. Immunity. 2022. PMID: 36370712 Free PMC article.
The long-term tumor control by IRF2-deficient CD8(+) T cells required continuous integration of both IFN-I and IFN-II signals. Thus, IRF2 is a foundational feedback molecule that redirects IFN signals to suppress T cell responses and represents a potential target to …
The long-term tumor control by IRF2-deficient CD8(+) T cells required continuous integration of both IFN-I and IFN-II signals. Thus, …
The IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic glycolysis.
Qi CL, Huang ML, Zou Y, Yang R, Jiang Y, Sheng JF, Kong YG, Tao ZZ, Feng HY, Hua QQ, Bu LH, Chen SM. Qi CL, et al. J Exp Clin Cancer Res. 2021 Dec 10;40(1):390. doi: 10.1186/s13046-021-02191-3. J Exp Clin Cancer Res. 2021. PMID: 34893086 Free PMC article.
CENP-N knockdown inhibited glucose metabolism, cell proliferation, cell cycling and promoted apoptosis. IRF2 is a transcription factor for CENP-N and directly promotes CENP-N expression in NPC cells. ...Both an AKT inhibitor (MK-2206) and a LDHA inhibitor (GSK2837808A) blo …
CENP-N knockdown inhibited glucose metabolism, cell proliferation, cell cycling and promoted apoptosis. IRF2 is a transcription facto …
Bcl6, Irf2, and Notch2 promote nonclassical monocyte development.
O'Connor KW, Liu T, Kim S, Briseño CG, Georgopoulos K, Murphy TL, Murphy KM. O'Connor KW, et al. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2220853120. doi: 10.1073/pnas.2220853120. Epub 2023 Aug 22. Proc Natl Acad Sci U S A. 2023. PMID: 37607223 Free PMC article.
Deletion of BCL6 from myeloid progenitors abrogated development of Ly6C(lo) monocytes. IRF2 was also required for Ly6C(lo) monocyte development in a cell-intrinsic manner. DLL1-induced in vitro transition into Ly6C(lo) TREML4(+) monocytes required IRF2 but unexpecte …
Deletion of BCL6 from myeloid progenitors abrogated development of Ly6C(lo) monocytes. IRF2 was also required for Ly6C(lo) monocyte d …
IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.
Li Y, Wang Y, Guo H, Wu Q, Hu Y. Li Y, et al. Mol Med Rep. 2022 Feb;25(2):40. doi: 10.3892/mmr.2021.12556. Epub 2021 Dec 8. Mol Med Rep. 2022. PMID: 34878155 Free PMC article.
Chromatin immunoprecipitation and dual luciferase reporter assay were used to verify the effect of IRF2 on GSDMD transcription. IRF2 was upregulated in MI mice. MI induced pyroptosis, as evidenced by increased GSDMD, N-terminal GSDMD (GSDMD-N), and cleaved (c-) casp …
Chromatin immunoprecipitation and dual luciferase reporter assay were used to verify the effect of IRF2 on GSDMD transcription. IR …
IRF2 is required for development and functional maturation of human NK cells.
Persyn E, Wahlen S, Kiekens L, Van Loocke W, Siwe H, Van Ammel E, De Vos Z, Van Nieuwerburgh F, Matthys P, Taghon T, Vandekerckhove B, Van Vlierberghe P, Leclercq G. Persyn E, et al. Front Immunol. 2022 Dec 5;13:1038821. doi: 10.3389/fimmu.2022.1038821. eCollection 2022. Front Immunol. 2022. PMID: 36544762 Free PMC article.
However, IRF2 knockdown greatly reduced the cell numbers of all early differentiation stages, resulting in decimated NK cell numbers. ...Thus, IRF2 plays an important role during development and functional maturation of human NK cells....
However, IRF2 knockdown greatly reduced the cell numbers of all early differentiation stages, resulting in decimated NK cell numbers. …
IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-kappaB/NFATc1 signaling.
Kim I, Kim JH, Kim K, Seong S, Lee KB, Kim N. Kim I, et al. BMB Rep. 2021 Sep;54(9):482-487. doi: 10.5483/BMBRep.2021.54.9.070. BMB Rep. 2021. PMID: 34488926 Free PMC article.
Although it has been reported that several IRFs are involved in bone metabolism, the role of IRF2 in bone cells has not been elucidated. Here, we investigated the involvement of IRF2 in RANKL-induced osteoclast differentiation. ...Conversely, IRF2 knockdown i …
Although it has been reported that several IRFs are involved in bone metabolism, the role of IRF2 in bone cells has not been elucidat …
IRF2-INPP4B-mediated autophagy suppresses apoptosis in acute myeloid leukemia cells.
Zhang F, Li J, Zhu J, Liu L, Zhu K, Cheng S, Lv R, Zhang P. Zhang F, et al. Biol Res. 2019 Mar 15;52(1):11. doi: 10.1186/s40659-019-0218-7. Biol Res. 2019. PMID: 30876449 Free PMC article.
Overexpression of IRF2 or INPP4B stimulated autophagy of AML cells, whereas inhibition of IRF2 or INPP4B resulted in the attenuation of autophagy. ...CONCLUSION: IRF2-INPP4B signaling axis attenuated apoptosis through induction of autophagy in AML cells....
Overexpression of IRF2 or INPP4B stimulated autophagy of AML cells, whereas inhibition of IRF2 or INPP4B resulted in the atten …
IRF2-induced Claudin-7 suppresses cell proliferation, invasion and migration of oral squamous cell carcinoma.
Li X, Yang W. Li X, et al. Exp Ther Med. 2022 Jan;23(1):7. doi: 10.3892/etm.2021.10929. Epub 2021 Oct 27. Exp Ther Med. 2022. PMID: 34815759 Free PMC article.
The effects of IRF2 and CLDN7 on the biological functions of OSCC cells were examined by transfection with short hairpin RNA (shRNA) against CLDN7 (sh-CLDN7), or IRF2 and CLDN7 overexpression plasmids. ...Additionally, IRF2 was confirmed to combine with the C …
The effects of IRF2 and CLDN7 on the biological functions of OSCC cells were examined by transfection with short hairpin RNA (shRNA) …
IRF2 Destabilizes Oncogenic KPNA2 to Modulate the Development of Osteosarcoma.
Xia S, Ma Y. Xia S, et al. J Oncol. 2022 Sep 26;2022:9973519. doi: 10.1155/2022/9973519. eCollection 2022. J Oncol. 2022. PMID: 36199790 Free PMC article.
KPNA2 was obviously upregulated, while IRF2 decreased significantly in OS tissues and cell lines, as well as negatively correlated with each other. KPNA2 removal remarkably suppressed OS cell growth, migration, invasion in vitro, and tumor growth in vivo, while IRF2 …
KPNA2 was obviously upregulated, while IRF2 decreased significantly in OS tissues and cell lines, as well as negatively correlated wi …
640 results