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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1992 1
1994 1
1995 2
1996 9
1997 4
1998 3
1999 7
2000 8
2001 10
2002 12
2003 11
2004 19
2005 18
2006 27
2007 31
2008 28
2009 26
2010 44
2011 54
2012 49
2013 65
2014 75
2015 88
2016 89
2017 71
2018 95
2019 93
2020 95
2021 91
2022 107
2023 77
2024 38

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1,209 results

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Page 1
IL1R1(+) cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer.
Koncina E, Nurmik M, Pozdeev VI, Gilson C, Tsenkova M, Begaj R, Stang S, Gaigneaux A, Weindorfer C, Rodriguez F, Schmoetten M, Klein E, Karta J, Atanasova VS, Grzyb K, Ullmann P, Halder R, Hengstschläger M, Graas J, Augendre V, Karapetyan YE, Kerger L, Zuegel N, Skupin A, Haan S, Meiser J, Dolznig H, Letellier E. Koncina E, et al. Nat Commun. 2023 Jul 17;14(1):4251. doi: 10.1038/s41467-023-39953-w. Nat Commun. 2023. PMID: 37460545 Free PMC article.
Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1(+), IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single c …
Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we ide …
IL-1 Signaling in Tumor Microenvironment.
Zhang W, Borcherding N, Kolb R. Zhang W, et al. Adv Exp Med Biol. 2020;1240:1-23. doi: 10.1007/978-3-030-38315-2_1. Adv Exp Med Biol. 2020. PMID: 32060884 Review.
IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects.
Feng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, Chun H, Faruk F, Kaplun E, Herbert Z, Copps KD, Ozcan U. Feng X, et al. Nat Med. 2019 Apr;25(4):575-582. doi: 10.1038/s41591-019-0358-x. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833749 Free PMC article.
We demonstrate that IL1R1-deficient mice are completely resistant to the effects of celastrol in leptin sensitization and treatment of obesity, diabetes, and nonalcoholic steatohepatitis. Thus, we conclude that IL1R1 is a gatekeeper for celastrol's metabolic actions …
We demonstrate that IL1R1-deficient mice are completely resistant to the effects of celastrol in leptin sensitization and treatment o …
IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease.
Umemura T, Fujinaga Y, Ashihara N, Ozawa M, Kuraishi Y, Watanabe T, Hamano H, Meguro A, Kawa S, Ota M. Umemura T, et al. Gene. 2022 Apr 30;820:146212. doi: 10.1016/j.gene.2022.146212. Epub 2022 Feb 7. Gene. 2022. PMID: 35143941
METHODS: A small scale of genome-wide association analysis identified that interleukin 1 receptor type 1 (IL1R1) gene variants were correlated with the development of IgG4-related periaortitis/periarteritis in 75 patients with IgG4-RD. Accordingly, 8 single nucleotide poly …
METHODS: A small scale of genome-wide association analysis identified that interleukin 1 receptor type 1 (IL1R1) gene variants were c …
Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1-IL1R1 Interaction in Mice.
Wen X, Yang Q, Sun D, Jiang ZY, Wang T, Liu HR, Han Z, Wang L, Liang CG. Wen X, et al. Int J Mol Sci. 2023 Feb 9;24(4):3530. doi: 10.3390/ijms24043530. Int J Mol Sci. 2023. PMID: 36834943 Free PMC article.
The results indicate that cumulus cells activated NF-kappaB signaling in oocytes through the IL1-IL1R1 interaction. Furthermore, it promoted mitochondrial dysfunction, excessive ROS accumulation, and increased early apoptosis, ultimately leading to a decline in the oocyte …
The results indicate that cumulus cells activated NF-kappaB signaling in oocytes through the IL1-IL1R1 interaction. Furthermore, it p …
Extricating human tumour immune alterations from tissue inflammation.
Mair F, Erickson JR, Frutoso M, Konecny AJ, Greene E, Voillet V, Maurice NJ, Rongvaux A, Dixon D, Barber B, Gottardo R, Prlic M. Mair F, et al. Nature. 2022 May;605(7911):728-735. doi: 10.1038/s41586-022-04718-w. Epub 2022 May 11. Nature. 2022. PMID: 35545675 Free PMC article.
Computational analysis identified tumour-enriched immune cell interactions, one of which yields a large population of regulatory T (T(reg)) cells that is highly enriched in the tumour and uniquely identified among all haematopoietically-derived cells in blood and tissue by co-exp …
Computational analysis identified tumour-enriched immune cell interactions, one of which yields a large population of regulatory T (T(reg)) …
Targeted plasma proteomics identifies MICA and IL1R1 proteins associated with HIV-1 reservoir size.
Blaauw MJT, Cristina Dos Santos J, Vadaq N, Trypsteen W, van der Heijden W, Groenendijk A, Zhang Z, Li Y, de Mast Q, Netea MG, Joosten LAB, Vandekerckhove L, van der Ven A, Matzaraki V. Blaauw MJT, et al. iScience. 2023 Mar 22;26(4):106486. doi: 10.1016/j.isci.2023.106486. eCollection 2023 Apr 21. iScience. 2023. PMID: 37091231 Free PMC article.
We tested whether plasma protein expression levels are associated with levels of cell-associated (CA) HIV-1 DNA and RNA in 211 virally suppressed people living with HIV (PLHIV). Plasma concentrations of FOLR1, IL1R1, MICA, and FETUB showed a positive association with CA HI …
We tested whether plasma protein expression levels are associated with levels of cell-associated (CA) HIV-1 DNA and RNA in 211 virally suppr …
ANGPTL3 negatively regulates IL-1beta-induced NF-kappaB activation by inhibiting the IL1R1-associated signaling complex assembly.
Zhang Y, Zhang ZT, Wan SY, Yang J, Wei YJ, Chen HJ, Zhou WZ, Song QY, Niu SX, Zheng L, Huang K. Zhang Y, et al. J Mol Cell Biol. 2023 Aug 26:mjad053. doi: 10.1093/jmcb/mjad053. Online ahead of print. J Mol Cell Biol. 2023. PMID: 37634084
The assembly of the receptor complex, consisting of the ligand IL-1beta, the IL-1 receptor (IL-1R) type 1 (IL1R1), and the IL-1R accessory protein (IL1RAP), initiates this signaling. ...Overexpression of ANGPTL3 inhibited IL-1beta-induced NF-kappaB activation and the trans …
The assembly of the receptor complex, consisting of the ligand IL-1beta, the IL-1 receptor (IL-1R) type 1 (IL1R1), and the IL-1R acce …
IL1R1 and IL1R2 polymorphisms were associated with tuberculosis risk: A pilot study.
Ren G, Dong Q, Huyan B, Jin P, Chen M. Ren G, et al. J Gene Med. 2018 Oct;20(10-11):e3057. doi: 10.1002/jgm.3057. Epub 2018 Oct 18. J Gene Med. 2018. PMID: 30256493
However, few studies have reported on the polymorphisms of IL1R1 and IL1R2 in TB patients. METHODS: We investigated nine single-nucleotide polymorphisms (SNPs) in IL1R1 and IL1R2 in 300 TB patients and 300 controls, aiming to evaluate their association with TB risk. …
However, few studies have reported on the polymorphisms of IL1R1 and IL1R2 in TB patients. METHODS: We investigated nine single-nucle …
1,209 results