IL1R1(+) cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer.
Koncina E, Nurmik M, Pozdeev VI, Gilson C, Tsenkova M, Begaj R, Stang S, Gaigneaux A, Weindorfer C, Rodriguez F, Schmoetten M, Klein E, Karta J, Atanasova VS, Grzyb K, Ullmann P, Halder R, Hengstschläger M, Graas J, Augendre V, Karapetyan YE, Kerger L, Zuegel N, Skupin A, Haan S, Meiser J, Dolznig H, Letellier E.
Koncina E, et al.
Nat Commun. 2023 Jul 17;14(1):4251. doi: 10.1038/s41467-023-39953-w.
Nat Commun. 2023.
PMID: 37460545
Free PMC article.
Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1(+), IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single c …
Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we ide …