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HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51.
Anand R, Buechelmaier E, Belan O, Newton M, Vancevska A, Kaczmarczyk A, Takaki T, Rueda DS, Powell SN, Boulton SJ. Anand R, et al. Nature. 2022 Jan;601(7892):268-273. doi: 10.1038/s41586-021-04261-0. Epub 2021 Dec 22. Nature. 2022. PMID: 34937945 Free PMC article.
Notably, HELQ binds to RPA and the RAD51-paralogue BCDX2 complex, but the relevance of these interactions and how HELQ functions in DSB repair remains unclear(3,5,6). ...Using biochemistry analyses and single-molecule imaging, we establish that RAD51 forms a complex …
Notably, HELQ binds to RPA and the RAD51-paralogue BCDX2 complex, but the relevance of these interactions and how HELQ functio …
HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review).
Tang N, Wen W, Liu Z, Xiong X, Wu Y. Tang N, et al. Oncol Rep. 2023 Dec;50(6):220. doi: 10.3892/or.2023.8657. Epub 2023 Nov 3. Oncol Rep. 2023. PMID: 37921071 Free PMC article. Review.
HELQ deficiency leads to subfertility, due to its critical role in germ cell stability. In addition, the abnormal expression of HELQ has been observed in multiple tumors and a number of molecular pathways, including the nucleotide excision repair, checkpoint kinase …
HELQ deficiency leads to subfertility, due to its critical role in germ cell stability. In addition, the abnormal expression of HE …
HELQ in cancer and reproduction.
Han X, Zhao L, Li X. Han X, et al. Neoplasma. 2016;63(6):825-835. doi: 10.4149/neo_2016_601. Neoplasma. 2016. PMID: 27565320 Review.
The recent discovery of HELQ in mouse model and human cancer cell reveal that genetic alteration of HELQ is involved in cancer susceptibility and subfertility. Here we review the origin, function and mechanisms of HELQ in maintaining genomic stability. Furthe …
The recent discovery of HELQ in mouse model and human cancer cell reveal that genetic alteration of HELQ is involved in cancer …
Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks.
Zhao Y, Hou K, Li Y, Hao S, Liu Y, Na Y, Li C, Cui J, Xu X, Wu X, Wang H. Zhao Y, et al. Nucleic Acids Res. 2023 Dec 11;51(22):12207-12223. doi: 10.1093/nar/gkad940. Nucleic Acids Res. 2023. PMID: 37897354 Free PMC article.
Mechanistically, HELQ helicase activity is required for EXO1-mediated DSB end resection, while ssDNA-binding capacity of HELQ is required for its recruitment to stalled forks, facilitating fork protection and preventing chromosome aberrations caused by replication s …
Mechanistically, HELQ helicase activity is required for EXO1-mediated DSB end resection, while ssDNA-binding capacity of HELQ …
Genetics of ovarian insufficiency and defects of folliculogenesis.
França MM, Mendonca BB. França MM, et al. Best Pract Res Clin Endocrinol Metab. 2022 Jan;36(1):101594. doi: 10.1016/j.beem.2021.101594. Epub 2021 Oct 14. Best Pract Res Clin Endocrinol Metab. 2022. PMID: 34794894 Review.
In addition, the majority of genes associated with nonsyndromic POI, widely expanded by high-throughput techniques over the last decade, have been implicated in ovarian development and meiosis/DNA repair pathways (ATG7, ATG9, ANKRD31, BMP8B, BMP15, BMPR1A, BMPR1B, BMPR2, BNC1, BR …
In addition, the majority of genes associated with nonsyndromic POI, widely expanded by high-throughput techniques over the last decade, hav …
HELQ suppresses migration and proliferation of non-small cell lung cancer cells by repairing DNA damage and inducing necrosis.
Zhong NS, Tong WL, Zhang Y, Xiao SN, Liu JM, Li AA, Yao GL, Lin Q, Liu ZL. Zhong NS, et al. Cell Biol Int. 2023 Jan;47(1):188-200. doi: 10.1002/cbin.11922. Epub 2022 Oct 2. Cell Biol Int. 2023. PMID: 36183369
HELQ plays a key role in DNA damage response and cell-cycle checkpoint regulation. ...Both in vitro and in vivo studies have shown that HELQ induces cell death. Mechanistically, we found that cells overexpressing HELQ showed a tendency to induce necrosis. ...
HELQ plays a key role in DNA damage response and cell-cycle checkpoint regulation. ...Both in vitro and in vivo studies have shown th …
HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.
Guo C, Gao YY, Ju QQ, Zhang CX, Gong M, Li ZL. Guo C, et al. J Transl Med. 2021 Jan 23;19(1):42. doi: 10.1186/s12967-021-02708-6. J Transl Med. 2021. PMID: 33485349 Free PMC article.
CONCLUSIONS: The expression of HELQ and EGR3 were correlated with IGHV mutation status in CLL patients. Additionally, the expression of HELQ/EGR3 were prognostic markers for CLL associating with targetable cell signaling pathways....
CONCLUSIONS: The expression of HELQ and EGR3 were correlated with IGHV mutation status in CLL patients. Additionally, the expression …
Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing.
He L, Lever R, Cubbon A, Tehseen M, Jenkins T, Nottingham AO, Horton A, Betts H, Fisher M, Hamdan SM, Soultanas P, Bolt EL. He L, et al. Nucleic Acids Res. 2023 Feb 28;51(4):1740-1749. doi: 10.1093/nar/gkad032. Nucleic Acids Res. 2023. PMID: 36718939 Free PMC article.
Using novel HelQ mutant proteins we identify that inhibition of Pol delta is independent of DNA binding, and maps to a 70 amino acid intrinsically disordered region of HelQ. Pol delta and its POLD3 subunit robustly stimulated DNA single-strand annealing by HelQ …
Using novel HelQ mutant proteins we identify that inhibition of Pol delta is independent of DNA binding, and maps to a 70 amino acid …
Cell-fate transition and determination analysis of mouse male germ cells throughout development.
Zhao J, Lu P, Wan C, Huang Y, Cui M, Yang X, Hu Y, Zheng Y, Dong J, Wang M, Zhang S, Liu Z, Bian S, Wang X, Wang R, Ren S, Wang D, Yao Z, Chang G, Tang F, Zhao XY. Zhao J, et al. Nat Commun. 2021 Nov 25;12(1):6839. doi: 10.1038/s41467-021-27172-0. Nat Commun. 2021. PMID: 34824237 Free PMC article.
Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells' identities. Ablation of HELQ induces developmental arrest and abnormal transcriptome reprogramming of male germ cells, indicating the importance of cell cycle regulat …
Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells' identities. Ablation of HELQ …
HELQ reverses the malignant phenotype of osteosarcoma cells via CHK1-RAD51 signaling pathway.
Liu DN, Zhou YF, Peng AF, Long XH, Chen XY, Liu ZL, Xia H. Liu DN, et al. Oncol Rep. 2017 Feb;37(2):1107-1113. doi: 10.3892/or.2016.5329. Epub 2016 Dec 20. Oncol Rep. 2017. PMID: 28000895
HELQ is a DNA helicase important for repair of DNA lesions and has been linked to several types of cancer. ...The results demonstrated that HELQ gene and protein were expressed in OS cells. OS cell invasion, migration, proliferation and DNA damage repair were enhanc …
HELQ is a DNA helicase important for repair of DNA lesions and has been linked to several types of cancer. ...The results demonstrate …
56 results