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Expression of the mouse MHC class Ib H2-T11 gene product, a paralog of H2-T23 (Qa-1) with shared peptide-binding specificity.
Chen L, Reyes-Vargas E, Dai H, Escobar H, Rudd B, Fairbanks J, Ho A, Cusick MF, Kumánovics A, Delgado J, He X, Jensen PE. Chen L, et al. J Immunol. 2014 Aug 1;193(3):1427-39. doi: 10.4049/jimmunol.1302048. Epub 2014 Jun 23. J Immunol. 2014. PMID: 24958902 Free PMC article.
The mouse MHC class Ib gene H2-T11 is 95% identical at the DNA level to H2-T23, which encodes Qa-1, one of the most studied MHC class Ib molecules. ...
The mouse MHC class Ib gene H2-T11 is 95% identical at the DNA level to H2-T23, which encodes Qa-1, one of the most studied MH …
Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis.
Balog S, Fujiwara R, Pan SQ, El-Baradie KB, Choi HY, Sinha S, Yang Q, Asahina K, Chen Y, Li M, Salomon M, Ng SW, Tsukamoto H. Balog S, et al. Hepatology. 2023 Jul 1;78(1):212-224. doi: 10.1002/hep.32793. Epub 2022 Oct 25. Hepatology. 2023. PMID: 36181700 Free PMC article.
AH activated HSCs had up-regulated inflammatory (chemokine [C-X-C motif] ligand 2 [Cxcl2], chemokine [C-C motif] ligand 2), antimicrobial (Il-33, Zc3h12a), and antigen presentation (H2-Q6, H2-T23) genes versus BDL and CCl 4 . Computational deconvolution of AH versus …
AH activated HSCs had up-regulated inflammatory (chemokine [C-X-C motif] ligand 2 [Cxcl2], chemokine [C-C motif] ligand 2), antimicrobial (I …
The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells.
Goodall KJ, Nguyen A, Sullivan LC, Andrews DM. Goodall KJ, et al. Mol Immunol. 2019 Nov;115:31-38. doi: 10.1016/j.molimm.2018.05.001. Epub 2018 May 20. Mol Immunol. 2019. PMID: 29789149 Review.
These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib …
These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, …
RIPK1-Induced A1 Reactive Astrocytes in Brain in MPTP-Treated Murine Model of Parkinson's Disease.
Qiao C, Niu G, Zhao W, Quan W, Zhou Y, Zhang M, Li T, Zhou S, Huang W, Zhao L, Wu J, Cui C, Shen Y. Qiao C, et al. Brain Sci. 2023 Apr 27;13(5):733. doi: 10.3390/brainsci13050733. Brain Sci. 2023. PMID: 37239205 Free PMC article.
Furthermore, inhibition of RIPK1 expression reduced A1 astrocytes' relative gene expression (CFB, H2-T23) and inflammatory cytokine or chemokine production (CCL2, TNF-alpha, IL-1beta) in the striatum of PD mice. ...
Furthermore, inhibition of RIPK1 expression reduced A1 astrocytes' relative gene expression (CFB, H2-T23) and inflammatory cyt …
Ursolic acid derivative UAOS-Na treats experimental autoimmune encephalomyelitis by immunoregulation and protecting myelin.
Wang M, Gu C, Yang Y, Chen L, Chen K, Du J, Wu H, Li Y. Wang M, et al. Front Neurol. 2023 Nov 30;14:1269862. doi: 10.3389/fneur.2023.1269862. eCollection 2023. Front Neurol. 2023. PMID: 38107649 Free PMC article.
Moreover, UAOS-Na downregulated the protein levels of Tapbp and H2-T23 in MHC-I antigen presentation pathway and reduced the proliferation of splenic CD8 T cells, thereby inhibiting the CNS infiltration of CD8 T cells. ...And it could reduce the inflammation of MS b …
Moreover, UAOS-Na downregulated the protein levels of Tapbp and H2-T23 in MHC-I antigen presentation pathway and reduced the p …
Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment.
Raguz J, Pinto C, Pölzlbauer T, Habbeddine M, Rosskopf S, Strauß J, Just V, Schmidt S, Bidet Huang K, Stemeseder F, Schippers T, Stewart E, Jez J, Berraondo P, Orlinger KK, Lauterbach H. Raguz J, et al. J Immunother Cancer. 2024 Apr 17;12(4):e008286. doi: 10.1136/jitc-2023-008286. J Immunother Cancer. 2024. PMID: 38631709 Free PMC article.
Still, there was evidence of immunosuppression built-up over time, and increased expression of H2-T23 (ligand for NKG2A T cell inhibitory receptor) following treatment was identified as a potential contributing factor. ...
Still, there was evidence of immunosuppression built-up over time, and increased expression of H2-T23 (ligand for NKG2A T cell …
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Anderson CK, Reilly EC, Lee AY, Brossay L. Anderson CK, et al. Cell Rep. 2019 Apr 9;27(2):537-548.e5. doi: 10.1016/j.celrep.2019.03.059. Cell Rep. 2019. PMID: 30970256 Free PMC article.
We also demonstrate that the MHC class Ib molecule Qa-1 (encoded by H2-T23) restricts a large, and critical, portion of this population. ...
We also demonstrate that the MHC class Ib molecule Qa-1 (encoded by H2-T23) restricts a large, and critical, portion of this p …
Differential transcript profiles of MHC class Ib(Qa-1, Qa-2, and Qa-10) and Aire genes during the ontogeny of thymus and other tissues.
Melo-Lima BL, Evangelista AF, de Magalhães DA, Passos GA, Moreau P, Donadi EA. Melo-Lima BL, et al. J Immunol Res. 2014;2014:159247. doi: 10.1155/2014/159247. Epub 2014 Apr 16. J Immunol Res. 2014. PMID: 24829926 Free PMC article.
Aiming to characterize the transcriptional profiles of nonclassical MHC class I genes in spatial-temporal association with the Aire expression, we evaluated the gene expression of H2-Q7(Qa-2), H2-T23(Qa-1), H2-Q10(Qa-10), and Aire during fetal and postnatal developm …
Aiming to characterize the transcriptional profiles of nonclassical MHC class I genes in spatial-temporal association with the Aire expressi …
The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice.
Melo-Lima BL, Espósito DL, da Fonseca BA, Figueiredo LT, Moreau P, Donadi EA. Melo-Lima BL, et al. Autoimmune Dis. 2015;2015:503087. doi: 10.1155/2015/503087. Epub 2015 Sep 17. Autoimmune Dis. 2015. PMID: 26457200 Free PMC article.
The YFV17D virus replicated in thymus and induced the expression of H2-Q7 (Qa-2/HLA-G) and H2-T23 (Qa-1/HLA-E) transcripts and repressed the expression of AIRE and FOXP3. Transcriptional expression varied according to tissue and mouse strain analyzed. Expression of …
The YFV17D virus replicated in thymus and induced the expression of H2-Q7 (Qa-2/HLA-G) and H2-T23 (Qa-1/HLA-E) transcripts and …
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