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GTF2H4 regulates partial EndMT via NF-kappaB activation through NCOA3 phosphorylation in ischemic diseases.
Fang Z, Zhao G, Zhao S, Yu X, Feng R, Zhang YE, Li H, Huang L, Guo Z, Zhang Z, Abdurahman M, Hong H, Li P, Wu B, Zhu J, Zhong X, Huang D, Lu H, Zhao X, Chen Z, Zhang W, Guo J, Zheng H, He Y, Qin S, Lu H, Zhao Y, Wang X, Ge J, Li H. Fang Z, et al. Innovation (Camb). 2024 Jan 8;5(2):100565. doi: 10.1016/j.xinn.2024.100565. eCollection 2024 Mar 4. Innovation (Camb). 2024. PMID: 38379791 Free PMC article.
Here, we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4 (GTF2H4) as a positive regulator of this process. In addition, we discovered that GTF2H4 collaborates with its ta …
Here, we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor I …
Lack of association between GTF2H4 genetic variants and AERD development and FEV1 decline by aspirin provocation.
Kim JY, Kim JH, Bae JS, Park BL, Uh ST, Kim MK, Choi IS, Cho SH, Park CS, Shin HD. Kim JY, et al. Int J Immunogenet. 2012 Dec;39(6):486-91. doi: 10.1111/j.1744-313X.2012.01118.x. Epub 2012 Apr 24. Int J Immunogenet. 2012. PMID: 22524621
In further multiple regression analysis, no genetic variants of GTF2H4 showed significant associations with FEV(1) decline by aspirin provocation in asthmatics (P > 0.05). Despite the need for replications in larger cohorts, our preliminary findings suggest that GTF2 …
In further multiple regression analysis, no genetic variants of GTF2H4 showed significant associations with FEV(1) decline by aspirin …
Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes.
Porter LF, Saptarshi N, Fang Y, Rathi S, den Hollander AI, de Jong EK, Clark SJ, Bishop PN, Olsen TW, Liloglou T, Chavali VRM, Paraoan L. Porter LF, et al. Clin Epigenetics. 2019 Jan 14;11(1):6. doi: 10.1186/s13148-019-0608-2. Clin Epigenetics. 2019. PMID: 30642396 Free PMC article.
Bisulfite pyrosequencing validated the differentially methylated locus cg18934822 in SKI, and cg22508626 within GTF2H4, and excluded global DNA methylation changes in the RPE in AMD. ...The novel differentially methylated genes SKI and GTF2H4 have not been previousl …
Bisulfite pyrosequencing validated the differentially methylated locus cg18934822 in SKI, and cg22508626 within GTF2H4, and excluded …
Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium.
Wang M, Liu H, Liu Z, Yi X, Bickeboller H, Hung RJ, Brennan P, Landi MT, Caporaso N, Christiani DC, Doherty JA; TRICL Research Team; Amos CI, Wei Q. Wang M, et al. Carcinogenesis. 2016 Sep;37(9):888-896. doi: 10.1093/carcin/bgw070. Epub 2016 Jun 10. Carcinogenesis. 2016. PMID: 27288692 Free PMC article.
The MSH5 rs3115672, but not GTF2H4 rs114596632, was strongly correlated with MSH5 rs3131379 in that region (r (2) = 1.000 and r (2) = 0.539, respectively) as reported in a previous GWAS. ...These provided evidence that functional genetic variants of GTF2H4 confer su …
The MSH5 rs3115672, but not GTF2H4 rs114596632, was strongly correlated with MSH5 rs3131379 in that region (r (2) = 1.000 and r (2) = …
RNA-Sequencing Analysis Indicates That N-Cadherin Promotes Prostate Cancer Progression by the Epigenetic Modification of Key Genes.
Quan Y, Ping H, Wang M, Zhang X. Quan Y, et al. DNA Cell Biol. 2023 Sep;42(9):563-577. doi: 10.1089/dna.2023.0089. Epub 2023 Aug 4. DNA Cell Biol. 2023. PMID: 37540080
Verifying DEGs through TCGA-PRAD dataset revealed six oncogenes (ARHGEF1, GRAMD1A, GTF2H4, MAPK8IP3, POLD1, and PTBP1) that were commonly upregulated by N-cadherin and in advanced PCa stages. ...
Verifying DEGs through TCGA-PRAD dataset revealed six oncogenes (ARHGEF1, GRAMD1A, GTF2H4, MAPK8IP3, POLD1, and PTBP1) that were comm …
LncRNA-mRNA competing endogenous RNA network depicts transcriptional regulation in ischaemia reperfusion injury.
Liu H, Xu D, Zhong X, Xu D, Chen G, Ge J, Li H. Liu H, et al. J Cell Mol Med. 2019 Mar;23(3):2272-2276. doi: 10.1111/jcmm.14163. Epub 2019 Jan 18. J Cell Mol Med. 2019. PMID: 30657634 Free PMC article.
Furthermore, combined with lncRNA-mRNA, lncRNA-miRNA and miRNA-mRNA network, 51 RNAs and 131 relationship pairs were ascertained in the competing endogenous RNAs (ceRNA) network. Among these nodes, SH2D3C and GTF2H4 were significantly enriched in cellular response to stres …
Furthermore, combined with lncRNA-mRNA, lncRNA-miRNA and miRNA-mRNA network, 51 RNAs and 131 relationship pairs were ascertained in the comp …
[Bioinformatics-based analysis of the effect of general Transcription Factor IIH on prognosis of Prostate cancer].
Li JC, Zhu XJ, Ye JH, Tan ZH, Cai SH, Deng YL, Chen J, Tian WC, Luo DH, Zhong WD. Li JC, et al. Zhonghua Yi Xue Za Zhi. 2024 Apr 23;104(16):1410-1417. doi: 10.3760/cma.j.cn112137-20231228-01504. Zhonghua Yi Xue Za Zhi. 2024. PMID: 38644292 Chinese.
The expression of GTF2H4 and MNAT1 were relevant to the pathological stages(P<0.05). ...Conclusion: GTF2H4, the key factor of TFIIH, is highly expressed in PCa and indicates a poor prognosis....
The expression of GTF2H4 and MNAT1 were relevant to the pathological stages(P<0.05). ...Conclusion: GTF2H4, the key factor …
Ronin influences the DNA damage response in pluripotent stem cells.
Seifert BA, Dejosez M, Zwaka TP. Seifert BA, et al. Stem Cell Res. 2017 Aug;23:98-104. doi: 10.1016/j.scr.2017.06.014. Epub 2017 Jul 3. Stem Cell Res. 2017. PMID: 28715716 Free PMC article.
Ronin binds to and regulates the genes encoding several DNA repair factors, including Gtf2h4 and Rad18, providing a potential mechanism for this phenotype. ...
Ronin binds to and regulates the genes encoding several DNA repair factors, including Gtf2h4 and Rad18, providing a potential mechani …
Genome-wide DNA methylation analysis of aggressive behaviour: a longitudinal population-based study.
Pishva E, van den Hove DLA, Laroche V, Lvovs A, Roy A, Ortega G, Burrage J, Veidebaum T, Kanarik M, Mill J, Lesch KP, Harro J. Pishva E, et al. J Child Psychol Psychiatry. 2023 Jul;64(7):998-1006. doi: 10.1111/jcpp.13782. Epub 2023 Mar 16. J Child Psychol Psychiatry. 2023. PMID: 36929374
The DMP annotated to the PDLIM5 gene, and DMRs resided in the vicinity of four protein-encoding genes (TRIM10, GTF2H4, SLC45A4, B3GALT4) and a long intergenic non-coding RNA (LINC02068). ...
The DMP annotated to the PDLIM5 gene, and DMRs resided in the vicinity of four protein-encoding genes (TRIM10, GTF2H4, SLC45A4, B3GAL …
Age-stratified proteomic characteristics and identification of promising precise clinical treatment targets of colorectal cancer.
Wang Q, Zhou Y, Zhou G, Qin G, Tan C, Yin T, Zhao D, Yao S. Wang Q, et al. J Proteomics. 2023 Apr 15;277:104863. doi: 10.1016/j.jprot.2023.104863. Epub 2023 Mar 2. J Proteomics. 2023. PMID: 36870673
Bioinformatic analysis showed that these differentially expressed proteins had different molecular functions and participated in extensive signaling pathways. We also revealed ADH1B, ARRDC1, GATM, GTF2H4, MGME1, and LILRB2 as possible cancer-promoting molecules, which migh …
Bioinformatic analysis showed that these differentially expressed proteins had different molecular functions and participated in extensive s …
21 results