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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2001 1
2002 36
2003 81
2004 123
2005 168
2006 212
2007 257
2008 310
2009 340
2010 401
2011 456
2012 507
2013 531
2014 512
2015 564
2016 273
2017 224
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2019 253
2020 271
2021 224
2022 134
2023 115
2024 47

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5,437 results

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Page 1
TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/beta-catenin degradation and is targeted for GSK3B/GSK3beta-mediated phosphorylation and degradation.
Wu H, Lu XX, Wang JR, Yang TY, Li XM, He XS, Li Y, Ye WL, Wu Y, Gan WJ, Guo PD, Li JM. Wu H, et al. Autophagy. 2019 Sep;15(9):1506-1522. doi: 10.1080/15548627.2019.1586250. Epub 2019 Mar 4. Autophagy. 2019. PMID: 30806153 Free PMC article.
Clinically, decreased expression of TRAF6 was associated with elevated GSK3B protein levels and activity and reduced overall survival in CRC patients. Pharmacological inhibition of GSK3B activity stabilized the TRAF6 protein, promoted CTNNB1 degradation, and effecti …
Clinically, decreased expression of TRAF6 was associated with elevated GSK3B protein levels and activity and reduced overall survival …
GSK3B induces autophagy by phosphorylating ULK1.
Ryu HY, Kim LE, Jeong H, Yeo BK, Lee JW, Nam H, Ha S, An HK, Park H, Jung S, Chung KM, Kim J, Lee BH, Cheong H, Kim EK, Yu SW. Ryu HY, et al. Exp Mol Med. 2021 Mar;53(3):369-383. doi: 10.1038/s12276-021-00570-6. Epub 2021 Mar 2. Exp Mol Med. 2021. PMID: 33654220 Free PMC article.
Here, we report that following insulin withdrawal, GSK3B directly interacted with and activated ULK1 via phosphorylation of S405 and S415 within the GABARAP-interacting region. ...Furthermore, high phosphorylation levels of ULK1 at S405 and S415 were observed in human panc …
Here, we report that following insulin withdrawal, GSK3B directly interacted with and activated ULK1 via phosphorylation of S405 and …
Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma.
Zhu MC, Zhang YH, Xiong P, Fan XW, Li GL, Zhu M. Zhu MC, et al. Cancer Gene Ther. 2022 Nov;29(11):1761-1772. doi: 10.1038/s41417-022-00489-8. Epub 2022 Jul 11. Cancer Gene Ther. 2022. PMID: 35821283
Furthermore, it was discovered that circ-GSK3B competitively sponged miR-3681-3p and miR-3909 to elevate GSK3B expression. ...In conclusion, circ-GSK3B suppressed LUAD development through up-regulating and activating GSK3B....
Furthermore, it was discovered that circ-GSK3B competitively sponged miR-3681-3p and miR-3909 to elevate GSK3B expression. ... …
Inhibition of GSK3B phosphorylation improves glucose and lipid metabolism disorder.
Yan Z, Cao X, Sun S, Sun B, Gao J. Yan Z, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166726. doi: 10.1016/j.bbadis.2023.166726. Epub 2023 May 3. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37146915
The enzyme activity analysis and cell staining results showed that HepG2 and NCTC-1469 cells transfected with GSK3B(Y216F) plasmid had significantly lower glucose and insulin levels, the decreased lipid deposition, and the increased glycogen synthesis than those transfecte …
The enzyme activity analysis and cell staining results showed that HepG2 and NCTC-1469 cells transfected with GSK3B(Y216F) plasmid ha …
GSK3B Overexpression Alleviates Posttraumatic Osteoarthritis in Mice by Promoting DNMT1-Mediated Hypermethylation of NR4A3 Promoter.
Lv Z, Sun D, Li X, Wu G. Lv Z, et al. Dis Markers. 2022 Jun 14;2022:4185489. doi: 10.1155/2022/4185489. eCollection 2022. Dis Markers. 2022. PMID: 35747513 Free PMC article.
Co-IP was used to analyze the interaction between GSK3B and DNMT1. Ch-IP and methylation-specific PCR assays were used for methylation. ...NR4A3 overexpression reversed the effect of GSK3B on IL-1beta-induced chondrocyte functions. GSK3B could recruit DNMT1 t …
Co-IP was used to analyze the interaction between GSK3B and DNMT1. Ch-IP and methylation-specific PCR assays were used for methylatio …
Discovery of Potent and Highly Selective Inhibitors of GSK3b.
An WF, Germain AR, Bishop JA, Nag PP, Metkar S, Ketterman J, Walk M, Weiwer M, Liu X, Patnaik D, Zhang YL, Gale J, Zhao W, Kaya T, Barker D, Wagner FF, Holson EB, Dandapani S, Perez J, Munoz B, Palmer M, Pan JQ, Haggarty SJ, Schreiber SL. An WF, et al. 2012 Apr 16 [updated 2014 May 13]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2012 Apr 16 [updated 2014 May 13]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23658955 Free Books & Documents. Review.
Subsequent chemical modifications of CID 5706819, guided by a co-crystal structure with GSK3b, and a battery of biochemical and cell-based assays led to CID 56840716/ML320 that inhibits GSK3b at IC(50) between 10-30 nM. ...Taken together, ML320 is a potent and highl …
Subsequent chemical modifications of CID 5706819, guided by a co-crystal structure with GSK3b, and a battery of biochemical and cell- …
MicroRNA-214-3p facilitates M2 macrophage polarization by targeting GSK3B.
Peng LY, Li BB, Deng KB, Wang WG. Peng LY, et al. Kaohsiung J Med Sci. 2022 Apr;38(4):347-356. doi: 10.1002/kjm2.12487. Epub 2022 Jan 10. Kaohsiung J Med Sci. 2022. PMID: 35005835 Free article.
MiR-214-3p facilitated M2 polarization of macrophages upon OVA stimulation. Mechanistically, miR-214-3p targeted the GSK3B 3' untranslated region in macrophages. In addition, GSK3B was downregulated in macrophages and nasal mucus tissues from AR patients. ...Overall …
MiR-214-3p facilitated M2 polarization of macrophages upon OVA stimulation. Mechanistically, miR-214-3p targeted the GSK3B 3' untrans …
Downregulation of GSK3B by miR-132-3p Enhances Etoposide-Induced Breast Cancer Cell Apoptosis.
Xu C, Du Z, Ren S, Pian Y. Xu C, et al. Ann Clin Lab Sci. 2021 May;51(3):285-294. Ann Clin Lab Sci. 2021. PMID: 34162557
Flow cytometry analysis was used to determine the effects of miR-132-3p and GSK3B on breast cancer cell apoptosis. Luciferase reporter assay, Western blot, and real-time PCR were used to determine the regulatory effect of miR-132-3p on GSK3B. ...The patients with lo …
Flow cytometry analysis was used to determine the effects of miR-132-3p and GSK3B on breast cancer cell apoptosis. Luciferase reporte …
5,437 results