Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 1
2009 2
2010 2
2011 2
2012 1
2013 6
2014 2
2016 1
2017 5
2018 7
2019 13
2020 17
2021 16
2022 15
2023 10
2024 3

Text availability

Article attribute

Article type

Publication date

Search Results

90 results

Results by year

Filters applied: . Clear all
Page 1
GINS2 Promotes Osteosarcoma Tumorigenesis via STAT3/MYC Axis.
Ren B, Zheng Y, Nie L, Wu F, Huang L, Wei J, Yang D. Ren B, et al. J Oncol. 2023 Feb 23;2023:8454142. doi: 10.1155/2023/8454142. eCollection 2023. J Oncol. 2023. PMID: 36873736 Free PMC article.
GINS2 is overexpressed in several cancers, but little is known about its role in osteosarcoma (OS). ...GINS2 knockdown hindered the growth and induced apoptosis in OS cell lines in vitro. ...
GINS2 is overexpressed in several cancers, but little is known about its role in osteosarcoma (OS). ...GINS2 knockdown hindere …
GINS2 promotes EMT in pancreatic cancer via specifically stimulating ERK/MAPK signaling.
Huang L, Chen S, Fan H, Ji D, Chen C, Sheng W. Huang L, et al. Cancer Gene Ther. 2021 Aug;28(7-8):839-849. doi: 10.1038/s41417-020-0206-7. Epub 2020 Aug 3. Cancer Gene Ther. 2021. PMID: 32747685 Free PMC article.
However, PD98059, a specific MEK1 inhibitor, reversed GINS2 overexpression-stimulated EMT in vitro. Conversely, GINS2 silencing inhibited EMT in PANC-1 cells, which was also rescued by GINS2-GFP. Moreover, GINS2 was colocalized and co-immunoprecipitate …
However, PD98059, a specific MEK1 inhibitor, reversed GINS2 overexpression-stimulated EMT in vitro. Conversely, GINS2 silencin …
GINS2 attenuates the development of lung cancer by inhibiting the STAT signaling pathway.
Sun D, Zong Y, Cheng J, Li Z, Xing L, Yu J. Sun D, et al. J Cancer. 2021 Jan 1;12(1):99-110. doi: 10.7150/jca.46744. eCollection 2021. J Cancer. 2021. PMID: 33391406 Free PMC article.
GINS complex subunit 2 (GINS2) controls DNA replication. GINS2 expression is upregulated in several kinds of aggressive tumors. However, the effect of GINS2 in lung cancer remains unclear. We performed TCGA database analysis to confirm the clinical significan …
GINS complex subunit 2 (GINS2) controls DNA replication. GINS2 expression is upregulated in several kinds of aggressive tumors …
GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1.
Hu H, Ye L, Liu Z. Hu H, et al. Mol Med Rep. 2022 Apr;25(4):117. doi: 10.3892/mmr.2022.12633. Epub 2022 Feb 9. Mol Med Rep. 2022. PMID: 35137928 Free PMC article.
By interacting with PTP4A1, GINS2 promoted the expression of PTP4A1, a novel p53 target. GINS2 knockdown was increased, while PTP4A1 overexpression decreased the protein level of p53. Notably, PTP4A1 overexpression partly reversed the effects of GINS2 downreg …
By interacting with PTP4A1, GINS2 promoted the expression of PTP4A1, a novel p53 target. GINS2 knockdown was increased, while …
Identification of GINS2 prognostic potential and involvement in immune cell infiltration in hepatocellular carcinoma.
Li Z, Song G, Guo D, Zhou Z, Qiu C, Xiao C, Wang X, Wang Y. Li Z, et al. J Cancer. 2022 Jan 1;13(2):610-622. doi: 10.7150/jca.53841. eCollection 2022. J Cancer. 2022. PMID: 35069907 Free PMC article.
Methods: The transcriptome profiles were retrieved from two public databases, GEO and TCGA. The median GINS2 expression was considered as cutoff to define GINS2 (high) and GINS2 (low) groups and to obtain differentially expressed genes. ...Conclusions: HCC pa …
Methods: The transcriptome profiles were retrieved from two public databases, GEO and TCGA. The median GINS2 expression was considere …
GINS2 Functions as a Key Gene in Lung Adenocarcinoma by WGCNA Co-Expression Network Analysis.
Tian W, Yang X, Yang H, Zhou B. Tian W, et al. Onco Targets Ther. 2020 Jul 8;13:6735-6746. doi: 10.2147/OTT.S255251. eCollection 2020. Onco Targets Ther. 2020. PMID: 32753902 Free PMC article.
Overexpression of GINS2 had a significantly negative connection with poor survival outcome. ...CONCLUSION: Our results explored that GINS2 functioned as an oncogene in lung adenocarcinoma, and suggested that GINS2 could act as a promising prognosis biomarker …
Overexpression of GINS2 had a significantly negative connection with poor survival outcome. ...CONCLUSION: Our results explored that …
Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin syndrome with craniosynostosis.
Nabais Sá MJ, Miller KA, McQuaid M, Koelling N, Wilkie AOM, Wurtele H, de Brouwer APM, Oliveira J. Nabais Sá MJ, et al. J Med Genet. 2022 Aug;59(8):776-780. doi: 10.1136/jmedgenet-2020-107572. Epub 2021 Aug 5. J Med Genet. 2022. PMID: 34353863 Free PMC article.
RESULTS: A novel homozygous missense variant NM_016095.2:c.341G>T, p.(Arg114Leu), in GINS2 was identified. Both non-consanguineous healthy parents carried this variant. ...Interestingly, our patient's phenotype is strikingly similar to the phenotype of patients with CDC …
RESULTS: A novel homozygous missense variant NM_016095.2:c.341G>T, p.(Arg114Leu), in GINS2 was identified. Both non-consanguineous …
GINS2 Is Downregulated in Peripheral Blood of Patients with Intervertebral Disk Degeneration and Promotes Proliferation and Migration of Nucleus Pulposus Cells.
Jiang H, Sun H, Dai J, Zhang C, Tang X. Jiang H, et al. Comput Math Methods Med. 2022 Sep 1;2022:1986348. doi: 10.1155/2022/1986348. eCollection 2022. Comput Math Methods Med. 2022. PMID: 36092790 Free PMC article. Retracted.
Moreover, ROC obtained a significantly higher AUC of GINS2 in IDD patients. Further, overexpressed GINS2 increased the proliferation, migration, and invasion of NP cells while overexpressed GINS2 decreased the apoptotic property of cells compared to the NC pl …
Moreover, ROC obtained a significantly higher AUC of GINS2 in IDD patients. Further, overexpressed GINS2 increased the prolife …
GINS2 facilitates epithelial-to-mesenchymal transition in non-small-cell lung cancer through modulating PI3K/Akt and MEK/ERK signaling.
Liu X, Sun L, Zhang S, Zhang S, Li W. Liu X, et al. J Cell Physiol. 2020 Nov;235(11):7747-7756. doi: 10.1002/jcp.29381. Epub 2019 Nov 4. J Cell Physiol. 2020. PMID: 31681988
GINS2 enhanced NSCLC cell proliferation, migration, and invasion viability in vivo and in vitro. GINS2 also promoted NSCLC cells EMT. In addition, GINS2 could regulate phosphorylated proteins of PI3K p85, Akt, MEK, and ERK expressions, it revealed that GIN …
GINS2 enhanced NSCLC cell proliferation, migration, and invasion viability in vivo and in vitro. GINS2 also promoted NSCLC cel …
E2F1-mediated GINS2 transcriptional activation promotes tumor progression through PI3K/AKT/mTOR pathway in hepatocellular carcinoma.
Zhang Y, Hao X, Han G, Lu Y, Chen Z, Zhang L, Wu J, Wang X. Zhang Y, et al. Am J Cancer Res. 2022 Apr 15;12(4):1707-1726. eCollection 2022. Am J Cancer Res. 2022. PMID: 35530279 Free PMC article.
Nevertheless, the exact mechanism of GINS2 in HCC remains to be elucidated. To systematically explore the significance of GINS2, we first assessed the relative expression of GINS2 in pan-cancers based on data obtained from the HCCDB, TIMER, and TCGA databases …
Nevertheless, the exact mechanism of GINS2 in HCC remains to be elucidated. To systematically explore the significance of GINS2 …
90 results