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Year Number of Results
1998 1
2000 3
2001 2
2003 1
2004 2
2005 1
2006 1
2007 2
2010 1
2013 2
2016 1
2017 1
2018 2
2019 1
2021 2
2023 2
2024 1

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25 results

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Page 1
Demethylation of GFRA4 Promotes Cell Proliferation and Invasion in Hirschsprung Disease.
Wang G, Zhang L, Wang H, Cui M, Liu W, Liu Y, Wu X. Wang G, et al. DNA Cell Biol. 2018 Apr;37(4):316-324. doi: 10.1089/dna.2017.3928. Epub 2018 Mar 13. DNA Cell Biol. 2018. PMID: 29634418
In this study, we found that GFRA4 expression was significantly reduced in HSCR tissues and cells through GFRA4 methylation by quantitative real-time PCR analysis, methylation-specific PCR, and bisulfite sequencing PCR. ...Moreover, we found upregulated GFRA4 …
In this study, we found that GFRA4 expression was significantly reduced in HSCR tissues and cells through GFRA4 methylation by …
GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway.
Zhang F, Cui M, Zhang L, Ma B, Guo F, Wang G. Zhang F, et al. Pediatr Res. 2024 Apr 24. doi: 10.1038/s41390-024-03158-8. Online ahead of print. Pediatr Res. 2024. PMID: 38658664
GFRA4 overexpression promoted proliferation and differentiation, and inhibited apoptosis in ENCSCs, while GFRA4 down-regulation had the opposite result. GFRA4 activated the hedgehog pathway. GFRA4 overexpression enhanced the expression of key factors o …
GFRA4 overexpression promoted proliferation and differentiation, and inhibited apoptosis in ENCSCs, while GFRA4 down-regulatio …
MiR-195-5p inhibits proliferation and invasion of nerve cells in Hirschsprung disease by targeting GFRA4.
Wang G, Wang H, Zhang L, Guo F, Wu X, Liu Y. Wang G, et al. Mol Cell Biochem. 2021 May;476(5):2061-2073. doi: 10.1007/s11010-021-04055-y. Epub 2021 Jan 30. Mol Cell Biochem. 2021. PMID: 33515383
The expression levels of GFRA4 and miR-195-5p in colon tissues were evaluated by real-time PCR (RT-PCR) assay. ...We also proved that GFRA4 is a direct target of miR-195-5p, and miR-195-5p inhibited proliferation, invasion, cell cycle arrest and differentiation, and …
The expression levels of GFRA4 and miR-195-5p in colon tissues were evaluated by real-time PCR (RT-PCR) assay. ...We also proved that …
Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development.
Lindahl M, Timmusk T, Rossi J, Saarma M, Airaksinen MS. Lindahl M, et al. Mol Cell Neurosci. 2000 Jun;15(6):522-33. doi: 10.1006/mcne.2000.0845. Mol Cell Neurosci. 2000. PMID: 10860579
Members of the GDNF protein family signal through receptors consisting of a GPI-linked GFRalpha subunit and the transmembrane tyrosine kinase Ret. Here we characterize the mouse Gfra4 and show that it undergoes developmentally regulated alternative splicing in several tiss …
Members of the GDNF protein family signal through receptors consisting of a GPI-linked GFRalpha subunit and the transmembrane tyrosine kinas …
Downregulation of microRNA-483-5p Promotes Cell Proliferation and Invasion by Targeting GFRA4 in Hirschsprung's Disease.
Wang G, Guo F, Wang H, Liu W, Zhang L, Cui M, Wu X. Wang G, et al. DNA Cell Biol. 2017 Nov;36(11):930-937. doi: 10.1089/dna.2017.3821. Epub 2017 Nov 1. DNA Cell Biol. 2017. PMID: 29090971
In this study, we found that miR-483-5p expression in HSCR tissues was significantly increased and their downregulation promoted cell proliferation, cell cycle progression and invasion and inhibited cell apoptosis in human 293T and SH-SY5Y cell lines by the CCK-8, flow cytometry, …
In this study, we found that miR-483-5p expression in HSCR tissues was significantly increased and their downregulation promoted cell prolif …
Expression of Glial-Cell-Line-Derived Neurotrophic Factor Family Ligands in Human Intervertebral Discs.
Iwasaki T, Akeda K, Kawaguchi K, Yamada J, Hasegawa T, Takegami N, Fujiwara T, Sudo A. Iwasaki T, et al. Int J Mol Sci. 2023 Nov 1;24(21):15874. doi: 10.3390/ijms242115874. Int J Mol Sci. 2023. PMID: 37958856 Free PMC article.
The mRNA expression of NRTN, ARTN, PSPN, and their receptors (GFRA2-GFRA4) was quantified using real-time PCR. Protein expression was evaluated using immunohistochemistry and Western blotting. The expression of NRTN, ARTN, PSPN, and their co-receptors (GFRA2-GFRA4) …
The mRNA expression of NRTN, ARTN, PSPN, and their receptors (GFRA2-GFRA4) was quantified using real-time PCR. Protein expression was …
ImmuneScore of eight-gene signature predicts prognosis and survival in patients with endometrial cancer.
Gu J, Wang Z, Wang BO, Ma X. Gu J, et al. Front Oncol. 2023 Mar 3;13:1097015. doi: 10.3389/fonc.2023.1097015. eCollection 2023. Front Oncol. 2023. PMID: 36937436 Free PMC article.
According to COX and HR values, NBAT1, a representative gene among 8 genes, was selected for CCK-8 assay, colony formation assay and transwell invasion assay to verify the effect on survival. RESULTS: Eight related genes (NBAT1, GFRA4, PTPRT, DLX4, RANBP3L, UNQ6494, KLRB1, …
According to COX and HR values, NBAT1, a representative gene among 8 genes, was selected for CCK-8 assay, colony formation assay and transwe …
Proteome-wide discovery of mislocated proteins in cancer.
Lee K, Byun K, Hong W, Chuang HY, Pack CG, Bayarsaikhan E, Paek SH, Kim H, Shin HY, Ideker T, Lee B. Lee K, et al. Genome Res. 2013 Aug;23(8):1283-94. doi: 10.1101/gr.155499.113. Epub 2013 May 14. Genome Res. 2013. PMID: 23674306 Free PMC article.
In particular, we found that the gene for the mislocating protein GFRA4 had a nonsynonymous point mutation in exon 2. Moreover, redirection of GFRA4 to its normal location, the plasma membrane, led to marked reductions in phospho-STAT3 and proliferation of glioma ce …
In particular, we found that the gene for the mislocating protein GFRA4 had a nonsynonymous point mutation in exon 2. Moreover, redir …
Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells.
Lindahl M, Poteryaev D, Yu L, Arumae U, Timmusk T, Bongarzone I, Aiello A, Pierotti MA, Airaksinen MS, Saarma M. Lindahl M, et al. J Biol Chem. 2001 Mar 23;276(12):9344-51. doi: 10.1074/jbc.M008279200. Epub 2000 Dec 14. J Biol Chem. 2001. PMID: 11116144 Free article.
Human and mouse GFRalpha4 lack the first Cys-rich domain characteristic of other GFRalpha receptors. Unlabeled PSPN displaces (125)I-PSPN from GFRA4-transfected cells, which express endogenous Ret. PSPN can be specifically cross-linked to mammalian GFRalpha4 and Ret, and i …
Human and mouse GFRalpha4 lack the first Cys-rich domain characteristic of other GFRalpha receptors. Unlabeled PSPN displaces (125)I-PSPN fr …
25 results