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1993 1
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2002 8
2003 15
2004 11
2005 17
2006 26
2007 24
2008 20
2009 26
2010 30
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2013 34
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590 results

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Page 1
Targeting the GFI1/1B-CoREST Complex in Acute Myeloid Leukemia.
van Bergen MGJM, van der Reijden BA. van Bergen MGJM, et al. Front Oncol. 2019 Oct 9;9:1027. doi: 10.3389/fonc.2019.01027. eCollection 2019. Front Oncol. 2019. PMID: 31649884 Free PMC article. Review.
Together with histone deacetylases CoREST regulates gene expression by histone 3 demethylation and deacetylation. The transcription factors GFI1 and GFI1B (for growth factor independence) are major interaction partners of KDM1A and recruit the CoREST complex to chromatin i …
Together with histone deacetylases CoREST regulates gene expression by histone 3 demethylation and deacetylation. The transcription factors …
Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications.
Möröy T, Khandanpour C. Möröy T, et al. Front Oncol. 2019 Aug 27;9:824. doi: 10.3389/fonc.2019.00824. eCollection 2019. Front Oncol. 2019. PMID: 31508375 Free PMC article. Review.
Also, a non-synonymous single nucleotide polymorphism (SNP) of GFI1, GFI1-36N, which encodes a variant GFI1 protein with a decreased efficiency to act as a transcriptional repressor, was found to be a prognostic factor for the development of AML and MDS. Both …
Also, a non-synonymous single nucleotide polymorphism (SNP) of GFI1, GFI1-36N, which encodes a variant GFI1 protein wit …
Gfi1 and Gfi1b: key regulators of hematopoiesis.
van der Meer LT, Jansen JH, van der Reijden BA. van der Meer LT, et al. Leukemia. 2010 Nov;24(11):1834-43. doi: 10.1038/leu.2010.195. Epub 2010 Sep 23. Leukemia. 2010. PMID: 20861919 Review.
Gfi1 expression is rapidly induced by cytokines that control both the adaptive and innate immune systems. ...In this study, we review how Gfi1 and its paralogue Gfi1b control the development of blood cells, discuss how changes in Gfi1 and Gfi1b function contr …
Gfi1 expression is rapidly induced by cytokines that control both the adaptive and innate immune systems. ...In this study, we review …
Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy.
Frank D, Patnana PK, Vorwerk J, Mao L, Gopal LM, Jung N, Hennig T, Ruhnke L, Frenz JM, Kuppusamy M, Autry R, Wei L, Sun K, Mohammed Ahmed HM, Künstner A, Busch H, Müller H, Hutter S, Hoermann G, Liu L, Xie X, Al-Matary Y, Nimmagadda SC, Cano FC, Heuser M, Thol F, Göhring G, Steinemann D, Thomale J, Leitner T, Fischer A, Rad R, Röllig C, Altmann H, Kunadt D, Berdel WE, Hüve J, Neumann F, Klingauf J, Calderon V, Opalka B, Dührsen U, Rosenbauer F, Dugas M, Varghese J, Reinhardt HC, von Bubnoff N, Möröy T, Lenz G, Batcha AMN, Giorgi M, Selvam M, Wang E, McWeeney SK, Tyner JW, Stölzel F, Mann M, Jayavelu AK, Khandanpour C. Frank D, et al. Blood. 2023 Dec 21;142(25):2175-2191. doi: 10.1182/blood.2022015752. Blood. 2023. PMID: 37756525 Free PMC article.
GFI1-36N is a germ line variant, causing a change of serine (S) to asparagine (N) at position 36. ...Targeting MGMT via temozolomide, a DNA alkylating drug, and HR via olaparib, a poly-ADP ribose polymerase 1 inhibitor, caused synthetic lethality in human and murine AML sa …
GFI1-36N is a germ line variant, causing a change of serine (S) to asparagine (N) at position 36. ...Targeting MGMT via temozolomide, …
Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment.
Beauchemin H, Möröy T. Beauchemin H, et al. Front Genet. 2020 Oct 26;11:591099. doi: 10.3389/fgene.2020.591099. eCollection 2020. Front Genet. 2020. PMID: 33193732 Free PMC article. Review.
Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small nuclear proteins that act as DNA binding transcriptional repressors. ...An additional explanation comes from recent data showing that both proteins may have additional non-transcriptional f …
Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small nuclear proteins that act as DNA binding transcri …
Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation.
Zhang Y, Dong F. Zhang Y, et al. Sci Rep. 2020 Oct 13;10(1):17115. doi: 10.1038/s41598-020-74278-4. Sci Rep. 2020. PMID: 33051558 Free PMC article.
Gfi1 is a zinc-finger transcriptional repressor that plays an important role in hematopoiesis. ...The mechanism by which Gfi1 collaborates with c-Myc in lymphomagenesis is incompletely understood. ...
Gfi1 is a zinc-finger transcriptional repressor that plays an important role in hematopoiesis. ...The mechanism by which Gfi1 …
Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.
Patnana PK, Liu L, Frank D, Nimmagadda SC, Behrens M, Ahmed H, Xie X, Liebmann M, Wei L, Gerdemann A, Thivakaran A, Humpf HU, Klotz L, Dugas M, Varghese J, Trajkovic-Arsic M, Siveke JT, Hanenberg H, Opalka B, Dührsen U, Reinhardt HC, Guenther U, von Bubnoff N, Khandanpour C. Patnana PK, et al. Br J Haematol. 2023 Sep;202(5):1033-1048. doi: 10.1111/bjh.18939. Epub 2023 Jul 9. Br J Haematol. 2023. PMID: 37423893
Growth factor independence 1 (GFI1) is a transcriptional repressor protein that plays an essential role in the differentiation of myeloid and lymphoid progenitors. ...We now demonstrate a novel role for dose-dependent GFI1 expression in regulating metabolism in haem …
Growth factor independence 1 (GFI1) is a transcriptional repressor protein that plays an essential role in the differentiation of mye …
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease.
Phelan JD, Shroyer NF, Cook T, Gebelein B, Grimes HL. Phelan JD, et al. Curr Opin Hematol. 2010 Jul;17(4):300-7. doi: 10.1097/MOH.0b013e32833a06f8. Curr Opin Hematol. 2010. PMID: 20571393 Free PMC article. Review.
Recent work has suggested that Gfi1 competes or collaborates with other transcription factors to modulate transcription programs and lineage decisions. SUMMARY: Gfi1 is central to several transcriptional circuits whose dysregulation leads to abnormal or malignant he …
Recent work has suggested that Gfi1 competes or collaborates with other transcription factors to modulate transcription programs and …
GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival.
Petrusca DN, Mulcrone PL, Macar DA, Bishop RT, Berdyshev E, Suvannasankha A, Anderson JL, Sun Q, Auron PE, Galson DL, Roodman GD. Petrusca DN, et al. Cancers (Basel). 2022 Feb 2;14(3):772. doi: 10.3390/cancers14030772. Cancers (Basel). 2022. PMID: 35159039 Free PMC article.
We found that expression of enzymes that control S1P biosynthesis, SphK1, dephosphorylation, and SGPP1 were differentially correlated with GFI1 levels in MM cells. We detected GFI1 occupancy on the SGGP1 gene in MM cells in a predicted enhancer region at the 5' end …
We found that expression of enzymes that control S1P biosynthesis, SphK1, dephosphorylation, and SGPP1 were differentially correlated with …
GFI1 as a novel prognostic and therapeutic factor for AML/MDS.
Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewski JP, Möröy T, Khandanpour C. Hönes JM, et al. Leukemia. 2016 Jun;30(6):1237-45. doi: 10.1038/leu.2016.11. Epub 2016 Feb 5. Leukemia. 2016. PMID: 26847026
We present data that low expression of GFI1 is associated with an inferior prognosis of AML patients. To elucidate the mechanism behind this, we generated a humanized mouse strain with reduced GFI1 expression (GFI1-KD). ...We investigated a new epigenetic the …
We present data that low expression of GFI1 is associated with an inferior prognosis of AML patients. To elucidate the mechanism behi …
590 results