The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.
Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U.
Niemann A, et al.
Brain. 2014 Mar;137(Pt 3):668-82. doi: 10.1093/brain/awt371. Epub 2014 Jan 29.
Brain. 2014.
PMID: 24480485
Free PMC article.
In search for a molecular mechanism we turned to the paralogue of GDAP1, GDAP1L1, which is mainly expressed in the unaffected central nervous system. GDAP1L1 responds to elevated levels of oxidized glutathione by translocating from the cytosol to mitochondria, where …
In search for a molecular mechanism we turned to the paralogue of GDAP1, GDAP1L1, which is mainly expressed in the unaffected central …