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Page 1
Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages.
Alalaiwe A, Chen CY, Chang ZY, Sung JT, Chuang SY, Fang JY. Alalaiwe A, et al. Int J Mol Sci. 2021 Sep 27;22(19):10410. doi: 10.3390/ijms221910410. Int J Mol Sci. 2021. PMID: 34638757 Free PMC article.
A transcriptomic assay of macrophages revealed that the expressions of pro-inflammatory mediators and GDAP1L1 were largely increased after an IMQ intervention. The depletion of GDAP1L1 by short hairpin (sh)RNA could inhibit cytokine release by macrophages. ...After …
A transcriptomic assay of macrophages revealed that the expressions of pro-inflammatory mediators and GDAP1L1 were largely increased …
2,4-Dimethoxy-6-Methylbenzene-1,3-diol, a Benzenoid From Antrodia cinnamomea, Mitigates Psoriasiform Inflammation by Suppressing MAPK/NF-kappaB Phosphorylation and GDAP1L1/Drp1 Translocation.
Chuang SY, Chen CY, Yang SC, Alalaiwe A, Lin CH, Fang JY. Chuang SY, et al. Front Immunol. 2021 May 14;12:664425. doi: 10.3389/fimmu.2021.664425. eCollection 2021. Front Immunol. 2021. PMID: 34054833 Free PMC article.
DMD could downregulate cytokine/chemokine by suppressing the phosphorylation of mitogen-activated protein kinases (MAPKs) and NF-kappaB. We also observed inhibition of GDAP1L1/Drp1 translocation from the cytoplasm to mitochondria by DMD intervention. ...
DMD could downregulate cytokine/chemokine by suppressing the phosphorylation of mitogen-activated protein kinases (MAPKs) and NF-kappaB. We …
The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.
Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U. Niemann A, et al. Brain. 2014 Mar;137(Pt 3):668-82. doi: 10.1093/brain/awt371. Epub 2014 Jan 29. Brain. 2014. PMID: 24480485 Free PMC article.
In search for a molecular mechanism we turned to the paralogue of GDAP1, GDAP1L1, which is mainly expressed in the unaffected central nervous system. GDAP1L1 responds to elevated levels of oxidized glutathione by translocating from the cytosol to mitochondria, where …
In search for a molecular mechanism we turned to the paralogue of GDAP1, GDAP1L1, which is mainly expressed in the unaffected central …
Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia.
Wang XX, Sun BF, Jiao J, Chong ZC, Chen YS, Wang XL, Zhao Y, Zhou YM, Li D. Wang XX, et al. Oncotarget. 2015 Mar 30;6(9):6535-43. doi: 10.18632/oncotarget.3163. Oncotarget. 2015. PMID: 25762640 Free PMC article.
Here, utilizing the chemical labeling and biotin-enrichment approach followed by Illumina HiSeq sequencing, we showed that (i) 6664, 9029 and 6318 genes contain 5hmC in normal, abnormal, and globozoospermia sperm, respectively; (ii) some 5hmC-containing genes significantly involv …
Here, utilizing the chemical labeling and biotin-enrichment approach followed by Illumina HiSeq sequencing, we showed that (i) 6664, 9029 an …
Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase.
Shield AJ, Murray TP, Board PG. Shield AJ, et al. Biochem Biophys Res Commun. 2006 Sep 8;347(4):859-66. doi: 10.1016/j.bbrc.2006.06.189. Epub 2006 Jul 20. Biochem Biophys Res Commun. 2006. PMID: 16857173
Mutations in the ganglioside-induced differentiation-associated protein 1 (GDAP1) gene have been linked with Charcot-Marie-Tooth (CMT) disease. This protein, and its paralogue GDAP1L1, appear to be structurally related to the cytosolic glutathione S-transferases (GST) incl …
Mutations in the ganglioside-induced differentiation-associated protein 1 (GDAP1) gene have been linked with Charcot-Marie-Tooth (CMT) disea …
MiR-150 blunts cardiac dysfunction in mice with cardiomyocyte loss of β1-adrenergic receptor/β-arrestin signaling and controls a unique transcriptome.
Moukette B, Kawaguchi S, Sepulveda MN, Hayasaka T, Aonuma T, Liangpunsakul S, Yang L, Dharmakumar R, Conway SJ, Kim IM. Moukette B, et al. Cell Death Discov. 2022 Dec 30;8(1):504. doi: 10.1038/s41420-022-01295-9. Cell Death Discov. 2022. PMID: 36585403 Free PMC article.
Our genome-wide circular RNA, long noncoding RNA (lncRNA), and mRNA profiling analyses unveil a subset of cardiac ncRNAs and genes as heretofore unrecognized mechanisms for beneficial actions of beta(1)AR/beta-arrestin signaling or miR-150. We further show that lncRNA Gm41664 and …
Our genome-wide circular RNA, long noncoding RNA (lncRNA), and mRNA profiling analyses unveil a subset of cardiac ncRNAs and genes as hereto …
Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes.
Marco A, Cuesta A, Pedrola L, Palau F, Marín I. Marco A, et al. Mol Biol Evol. 2004 Jan;21(1):176-87. doi: 10.1093/molbev/msh013. Epub 2003 Oct 31. Mol Biol Evol. 2004. PMID: 14595091
The protein encoded by GDAP1 shows clear similarity to glutathione transferases (also known as glutathione S-transferases or GSTs). The human genome contains a paralog of GDAP1 called GDAP1L1. Using comparative genomics, we show that orthologs of GDAP1 and GDAP1L1 a …
The protein encoded by GDAP1 shows clear similarity to glutathione transferases (also known as glutathione S-transferases or GSTs). The huma …
RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression.
Sadr AS, Nassiri M, Ghaderi-Zefrehei M, Heidari M, Smith J, Muhaghegh Dolatabady M. Sadr AS, et al. Genes (Basel). 2023 Mar 25;14(4):793. doi: 10.3390/genes14040793. Genes (Basel). 2023. PMID: 37107551 Free PMC article.
Furthermore, our results demonstrated that the SPARC, ATP6V0D2, IL4I1, SMPDL3A, ADAM7, TMCC3, ULK2, MYO6, THG1L and IRG1 genes were the most significantly expressed genes in the commercial birds and the PAPPA, DUSP1, PSMD12, LHX8, IL8, TRPM2, GDAP1L1, FAM161A, ABCC2 and AS …
Furthermore, our results demonstrated that the SPARC, ATP6V0D2, IL4I1, SMPDL3A, ADAM7, TMCC3, ULK2, MYO6, THG1L and IRG1 genes were the most …
In Silico Transcriptomic Analysis of the Chloride Intracellular Channels (CLIC) Interactome Identifies a Molecular Panel of Seven Prognostic Markers in Patients with Pancreatic Ductal Adenocarcinoma.
Magouliotis DE, Sakellaridis N, Dimas K, Tasiopoulou VS, Svokos KA, Svokos AA, Zacharoulis D. Magouliotis DE, et al. Curr Genomics. 2020 Feb;21(2):119-127. doi: 10.2174/1389202921666200316115631. Curr Genomics. 2020. PMID: 32655306 Free PMC article.
A molecular signature of seven genes (Chloride Intracellular Channel 1 - CLIC1; Chloride Intracellular Channel 3 - CLIC3; Chloride Intracellular Channel 4 - CLIC4; Ganglioside Induced Differentiation Associated Protein 1 - GDAP1; Ganglioside Induced Differentiation Associated Pro …
A molecular signature of seven genes (Chloride Intracellular Channel 1 - CLIC1; Chloride Intracellular Channel 3 - CLIC3; Chloride Intracell …
Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology.
Bardy C, van den Hurk M, Kakaradov B, Erwin JA, Jaeger BN, Hernandez RV, Eames T, Paucar AA, Gorris M, Marchand C, Jappelli R, Barron J, Bryant AK, Kellogg M, Lasken RS, Rutten BP, Steinbusch HW, Yeo GW, Gage FH. Bardy C, et al. Mol Psychiatry. 2016 Nov;21(11):1573-1588. doi: 10.1038/mp.2016.158. Epub 2016 Oct 4. Mol Psychiatry. 2016. PMID: 27698428 Free PMC article.
As further proof of concept, we selected one of the potential neurophysiological biomarkers identified in this study-GDAP1L1-to isolate highly functional live human neurons in vitro....
As further proof of concept, we selected one of the potential neurophysiological biomarkers identified in this study-GDAP1L1-to isola …
12 results