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Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands.
Jung J, Enterina JR, Bui DT, Mozaneh F, Lin PH, Nitin, Kuo CW, Rodrigues E, Bhattacherjee A, Raeisimakiani P, Daskhan GC, St Laurent CD, Khoo KH, Mahal LK, Zandberg WF, Huang X, Klassen JS, Macauley MS. Jung J, et al. ACS Chem Biol. 2021 Nov 19;16(11):2673-2689. doi: 10.1021/acschembio.1c00501. Epub 2021 Oct 18. ACS Chem Biol. 2021. PMID: 34661385
Overexpression of three CHSTsCHST1, CHST2, or CHST4significantly enhance the binding of numerous Siglecs. Unexpectedly, two other CHSTs (Gal3ST2 and Gal3ST3) diminish Siglec binding, suggesting a new mode to modulate Siglec ligands via sulfation. ...
Overexpression of three CHSTsCHST1, CHST2, or CHST4significantly enhance the binding of numerous Siglecs. Unexpectedly, two other CHSTs (Gal …
Identification of mono- and disulfated N-acetyl-lactosaminyl Oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer.
Shibata TK, Matsumura F, Wang P, Yu S, Chou CC, Khoo KH, Kitayama K, Akama TO, Sugihara K, Kanayama N, Kojima-Aikawa K, Seeberger PH, Fukuda M, Suzuki A, Aoki D, Fukuda MN. Shibata TK, et al. J Biol Chem. 2012 Feb 24;287(9):6592-602. doi: 10.1074/jbc.M111.305334. Epub 2011 Dec 22. J Biol Chem. 2012. PMID: 22194598 Free PMC article.
When cells were first co-transfected with GAL3ST3 and B3GNT7 and then with CHST1, the resulting cells strongly expressed HMOCC-1 antigen. However, when cells were transfected with a mixture of GAL3ST3 and CHST1 before or after transfection with B3GNT7, the number of …
When cells were first co-transfected with GAL3ST3 and B3GNT7 and then with CHST1, the resulting cells strongly expressed HMOCC-1 anti …
Engineering of a 3'-sulpho-Galβ1-4GlcNAc-specific probe by a single amino acid substitution of a fungal galectin.
Hu D, Huang H, Tateno H, Nakakita S, Sato T, Narimatsu H, Yao X, Hirabayashi J. Hu D, et al. J Biochem. 2015 Apr;157(4):197-200. doi: 10.1093/jb/mvv023. Epub 2015 Mar 11. J Biochem. 2015. PMID: 25762728
Moreover, E86A specifically bound to HeLa cells, in which galactose-3-O-sulfotransferases (Gal3ST2 or Gal3ST3) were over-expressed....
Moreover, E86A specifically bound to HeLa cells, in which galactose-3-O-sulfotransferases (Gal3ST2 or Gal3ST3) were over-expressed... …
Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models.
Deng F, Shen L, Wang H, Zhang L. Deng F, et al. Am J Cancer Res. 2020 Dec 1;10(12):4624-4639. eCollection 2020. Am J Cancer Res. 2020. PMID: 33415023 Free PMC article.
Similarly, BDKRB2, TERC, DNAJA3, MRPL15, SLC16A13, CRHBP and ACSBG2 were associated with alive with progression and GAL3ST3, AD2, RAB41, HDC, and PLEKHG1 associated with dead with disease, respectively, while also inversely linked other outcomes. ...
Similarly, BDKRB2, TERC, DNAJA3, MRPL15, SLC16A13, CRHBP and ACSBG2 were associated with alive with progression and GAL3ST3, AD2, RAB …
Associations of Heavy Metals with Cognitive Function: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.
Wei Y, Zhou YF, Xiao L, Qin J, Cheng H, Cai H, Chen X, Zou Y, Yang L, Zhang H, Zhang Z, Yang X. Wei Y, et al. Ann Neurol. 2024 Apr 25. doi: 10.1002/ana.26942. Online ahead of print. Ann Neurol. 2024. PMID: 38661228
The methylation levels at cg05226051 (annotated to TDRD3) and cg18886932 (annotated to GAL3ST3) mediated 24.8% and 25.5% of the association between blood arsenic and cognitive function, respectively (all p < 0.05). ...
The methylation levels at cg05226051 (annotated to TDRD3) and cg18886932 (annotated to GAL3ST3) mediated 24.8% and 25.5% of the assoc …
Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis.
Soga K, Yamauchi J, Kawai Y, Yamada M, Uchikawa R, Tegoshi T, Mitsufuji S, Yoshikawa T, Arizono N. Soga K, et al. Parasitol Res. 2008 Nov;103(6):1427-34. doi: 10.1007/s00436-008-1152-8. Epub 2008 Aug 21. Parasitol Res. 2008. PMID: 18716796
Real-time polymerase chain reaction studies on the gene transcription levels of O-glycan sulfotransferases Gal3ST1, Gal3ST2, Gal3ST3, and Gal3ST4 in the jejunal epithelium increased gradually toward day 28 post-infection in euthymic and athymic rats. ...
Real-time polymerase chain reaction studies on the gene transcription levels of O-glycan sulfotransferases Gal3ST1, Gal3ST2, Gal3ST3, …
Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide.
Chandrasekaran EV, Lakhaman SS, Chawda R, Piskorz CF, Neelamegham S, Matta KL. Chandrasekaran EV, et al. J Biol Chem. 2004 Mar 12;279(11):10032-41. doi: 10.1074/jbc.M311989200. Epub 2003 Dec 29. J Biol Chem. 2004. PMID: 14701868 Free article.