Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1976 1
1985 2
1986 1
1991 2
1995 2
1996 1
1997 4
1998 2
1999 6
2000 9
2001 6
2002 7
2003 4
2004 27
2005 32
2006 19
2007 15
2008 13
2009 22
2010 23
2011 22
2012 24
2013 37
2014 56
2015 54
2016 66
2017 57
2018 68
2019 65
2020 69
2021 101
2022 85
2023 91
2024 39

Text availability

Article attribute

Article type

Publication date

Search Results

912 results

Results by year

Filters applied: . Clear all
Page 1
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Pastushenko I, Mauri F, Song Y, de Cock F, Meeusen B, Swedlund B, Impens F, Van Haver D, Opitz M, Thery M, Bareche Y, Lapouge G, Vermeersch M, Van Eycke YR, Balsat C, Decaestecker C, Sokolow Y, Hassid S, Perez-Bustillo A, Agreda-Moreno B, Rios-Buceta L, Jaen P, Redondo P, Sieira-Gil R, Millan-Cayetano JF, Sanmatrtin O, D'Haene N, Moers V, Rozzi M, Blondeau J, Lemaire S, Scozzaro S, Janssens V, De Troya M, Dubois C, Pérez-Morga D, Salmon I, Sotiriou C, Helmbacher F, Blanpain C. Pastushenko I, et al. Nature. 2021 Jan;589(7842):448-455. doi: 10.1038/s41586-020-03046-1. Epub 2020 Dec 16. Nature. 2021. PMID: 33328637 Free PMC article.
FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers(1-5). ...We also found this hybrid EMT state in FAT1-mutated human squamous cell carcinomas. Skin squamous cell carcinomas in which Fat1 was deleted presented in …
FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers(1-5). ...We also found this hybrid …
The FAT1 Cadherin Drives Vascular Smooth Muscle Cell Migration.
Riascos-Bernal DF, Ressa G, Korrapati A, Sibinga NES. Riascos-Bernal DF, et al. Cells. 2023 Jun 14;12(12):1621. doi: 10.3390/cells12121621. Cells. 2023. PMID: 37371091 Free PMC article. Review.
In cancer biology, however, the effect of FAT1 on migration depends on the cancer type or context, as FAT1 either suppresses or enhances cancer cell migration and invasion. With this review, we describe what is known about FAT1's effects on cell migration as …
In cancer biology, however, the effect of FAT1 on migration depends on the cancer type or context, as FAT1 either suppresses o …
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2.
Li R, Shao J, Jin YJ, Kawase H, Ong YT, Troidl K, Quan Q, Wang L, Bonnavion R, Wietelmann A, Helmbacher F, Potente M, Graumann J, Wettschureck N, Offermanns S. Li R, et al. Nat Commun. 2023 Apr 8;14(1):1980. doi: 10.1038/s41467-023-37671-x. Nat Commun. 2023. PMID: 37031213 Free PMC article.
We show that loss of endothelial FAT1 results in increased endothelial cell proliferation in vitro and in various angiogenesis models in vivo. This effect is due to perturbed YAP/TAZ protein degradation, leading to increased YAP/TAZ protein levels and expression of canonic …
We show that loss of endothelial FAT1 results in increased endothelial cell proliferation in vitro and in various angiogenesis models …
Role of FAT1 in health and disease.
Peng Z, Gong Y, Liang X. Peng Z, et al. Oncol Lett. 2021 May;21(5):398. doi: 10.3892/ol.2021.12659. Epub 2021 Mar 18. Oncol Lett. 2021. PMID: 33777221 Free PMC article. Review.
Abnormal FAT1 expression may lead to the development of tumors and may affect prognosis. Therefore, FAT1 may have potential in tumor therapy. The structural and functional changes mediated by FAT1, its tissue distribution and changes in FAT1 expression …
Abnormal FAT1 expression may lead to the development of tumors and may affect prognosis. Therefore, FAT1 may have potential in …
Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway.
Li Z, Razavi P, Li Q, Toy W, Liu B, Ping C, Hsieh W, Sanchez-Vega F, Brown DN, Da Cruz Paula AF, Morris L, Selenica P, Eichenberger E, Shen R, Schultz N, Rosen N, Scaltriti M, Brogi E, Baselga J, Reis-Filho JS, Chandarlapaty S. Li Z, et al. Cancer Cell. 2018 Dec 10;34(6):893-905.e8. doi: 10.1016/j.ccell.2018.11.006. Cancer Cell. 2018. PMID: 30537512 Free PMC article.
We conducted a genomic analysis of 348 estrogen receptor-positive (ER(+)) breast cancers treated with CDK4/6i and identified loss-of-function mutations affecting FAT1 and RB1 linked to drug resistance. FAT1 loss led to marked elevations in CDK6, the suppression of w …
We conducted a genomic analysis of 348 estrogen receptor-positive (ER(+)) breast cancers treated with CDK4/6i and identified loss-of-functio …
The diverse functions of FAT1 in cancer progression: good, bad, or ugly?
Chen ZG, Saba NF, Teng Y. Chen ZG, et al. J Exp Clin Cancer Res. 2022 Aug 15;41(1):248. doi: 10.1186/s13046-022-02461-8. J Exp Clin Cancer Res. 2022. PMID: 35965328 Free PMC article. Review.
FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in many types of cancer. ...However, in some types of cancer, overexpression of FAT1 leads to EMT. The roles of FAT1 in cancer progression, which seems to be cancer-type specific, have …
FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in many types of cancer. ...However, in some types of cance …
The Atypical Cadherin FAT1 Limits Mitochondrial Respiration and Proliferation of Vascular Smooth Muscle Cells.
Riascos-Bernal DF, Maira A, Sibinga NES. Riascos-Bernal DF, et al. Front Cardiovasc Med. 2022 May 11;9:905717. doi: 10.3389/fcvm.2022.905717. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35647082 Free PMC article. Review.
However, the understanding of cell metabolism during smooth muscle cell phenotypic modulation is incipient. Studies of the atypical cadherin FAT1, which is strongly upregulated in smooth muscle cells in response to arterial injury, suggest that it has important and distinc …
However, the understanding of cell metabolism during smooth muscle cell phenotypic modulation is incipient. Studies of the atypical cadherin …
FAT1 expression in T-cell acute lymphoblastic leukemia (T-ALL) modulates proliferation and WNT signaling.
Liebig S, Neumann M, Silva P, Ortiz-Tanchez J, Schulze V, Isaakidis K, Schlee C, Schroeder MP, Beder T, Morris LGT, Chan TA, Bastian L, Burmeister T, Schwartz S, Gökbuget N, Mochmann LH, Baldus CD. Liebig S, et al. Sci Rep. 2023 Jan 18;13(1):972. doi: 10.1038/s41598-023-27792-0. Sci Rep. 2023. PMID: 36653435 Free PMC article.
In our T-ALL cohort, 53% of patient samples were FAT1 positive (FAT1pos) compared to only 16% FAT1 positivity in early T-ALL patient samples. Aberrant expression of FAT1 was strongly associated with FAT1 promotor hypomethylation, yet a subset, mainly c …
In our T-ALL cohort, 53% of patient samples were FAT1 positive (FAT1pos) compared to only 16% FAT1 positivity in early T-ALL p …
FAT1 Gene Expression in Iranian Acute Lymphoid and Myeloid Leukemia Patients.
Ostadali Dehagi M, Rostami S, Shamshiri A, Safari F, Haji Hosseini R, Thorne RF, Ghavamzadeh A. Ostadali Dehagi M, et al. Int J Hematol Oncol Stem Cell Res. 2023 Apr 1;17(2):81-88. doi: 10.18502/ijhoscr.v17i2.12644. Int J Hematol Oncol Stem Cell Res. 2023. PMID: 37637767 Free PMC article.
FAT1 overexpression has been reported in hematological malignancies. ...Then, quantitative real-time polymerase chain reaction (qPCR) was used to compare FAT1 gene expression. RESULTS: Overall, there were no significant differences in FAT1 expression between …
FAT1 overexpression has been reported in hematological malignancies. ...Then, quantitative real-time polymerase chain reaction (qPCR) …
FAT1 cadherin controls neuritogenesis during NTera2 cell differentiation.
Ahmed AF, de Bock CE, Sontag E, Hondermarck H, Lincz LF, Thorne RF. Ahmed AF, et al. Biochem Biophys Res Commun. 2019 Jun 30;514(3):625-631. doi: 10.1016/j.bbrc.2019.04.197. Epub 2019 May 7. Biochem Biophys Res Commun. 2019. PMID: 31076104
Depletion of FAT1 with siRNA decreased the number of neurites produced after RA treatment. Moreover, FAT1 silencing also led to decreased Ser127-phosphorylation of YAP along with transcriptional increases in the Hippo target genes CTGF and ANKRD1, suggesting FAT1 …
Depletion of FAT1 with siRNA decreased the number of neurites produced after RA treatment. Moreover, FAT1 silencing also led t …
912 results