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Year Number of Results
1997 2
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2000 7
2001 3
2002 7
2003 12
2004 9
2005 13
2006 7
2007 11
2008 15
2009 10
2010 10
2011 15
2012 16
2013 14
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276 results

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Page 1
Paradoxes of the EphB1 receptor in malignant brain tumors.
Wei W, Wang H, Ji S. Wei W, et al. Cancer Cell Int. 2017 Feb 8;17:21. doi: 10.1186/s12935-017-0384-z. eCollection 2017. Cancer Cell Int. 2017. PMID: 28194092 Free PMC article. Review.
This review focuses on EphB1 that has both tumor-suppressing and -promoting roles in some brain tumors. Understanding the intracellular mechanisms of EphB1 in tumorigenesis and metastasis of brain tumors might provide a foundation for the development of EphB1 …
This review focuses on EphB1 that has both tumor-suppressing and -promoting roles in some brain tumors. Understanding the intracellul …
EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis.
Tiruppathi C, Regmi SC, Wang DM, Mo GCH, Toth PT, Vogel SM, Stan RV, Henkemeyer M, Minshall RD, Rehman J, Malik AB. Tiruppathi C, et al. Mol Biol Cell. 2020 May 15;31(11):1167-1182. doi: 10.1091/mbc.E19-12-0713. Epub 2020 Apr 2. Mol Biol Cell. 2020. PMID: 32238105 Free PMC article.
Activation of EphB1 with its ligand Ephrin B1 induced EphB1 phosphorylation and the uncoupling EphB1 from Cav-1 and thereby promoted phosphorylation of Cav-1 by Src. ...We also observed that Cav-1 protein expression and caveolae numbers were markedly reduced …
Activation of EphB1 with its ligand Ephrin B1 induced EphB1 phosphorylation and the uncoupling EphB1 from Cav-1 and the …
Colorectal cancer-associated mutations impair EphB1 kinase function.
Kim Y, Ahmed S, Miller WT. Kim Y, et al. J Biol Chem. 2023 Sep;299(9):105115. doi: 10.1016/j.jbc.2023.105115. Epub 2023 Jul 30. J Biol Chem. 2023. PMID: 37527777 Free PMC article.
The most frequently mutated Eph receptor in metastatic CRC is EphB1. However, the functional effects of EphB1 mutations are mostly unknown. ...In contrast to the WT, the mutant EphB1 receptors are unable to suppress the migration of human CRC cells. ...
The most frequently mutated Eph receptor in metastatic CRC is EphB1. However, the functional effects of EphB1 mutations are mo …
Cell-cell contact-driven EphB1 cis- and trans- signalings regulate cancer stem cells enrichment after chemotherapy.
Wang L, Peng Q, Xie Y, Yin N, Xu J, Chen A, Yi J, Shi W, Tang J, Xiang J. Wang L, et al. Cell Death Dis. 2022 Nov 19;13(11):980. doi: 10.1038/s41419-022-05385-5. Cell Death Dis. 2022. PMID: 36402751 Free PMC article.
Gene expression profiling suggested a dynamic regulatory mechanism during the process of enrichment of cancer stem cells, where Nanog showed upregulation in the dormant state and SOX2 showed upregulation in the reactivated state. Further, we showed that EphB1 and p-EphB …
Gene expression profiling suggested a dynamic regulatory mechanism during the process of enrichment of cancer stem cells, where Nanog showed …
EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System.
Kampen KR, Scherpen FJ, Garcia-Manero G, Yang H, Kaspers GJ, Cloos J, Zwaan CM, van den Heuvel-Eibrink MM, Kornblau SM, De Bont ES. Kampen KR, et al. Mol Cancer Res. 2015 Jun;13(6):982-92. doi: 10.1158/1541-7786.MCR-14-0660-T. Epub 2015 May 5. Mol Cancer Res. 2015. PMID: 25944917 Free PMC article.
In AML cells, EphB1 transcript was inversely correlated with EphB1 promoter methylation. ...Combined, the contribution of EphB1 to the DDR system reveals a tumor-suppressor function for EphB1 in pediatric AML. ...
In AML cells, EphB1 transcript was inversely correlated with EphB1 promoter methylation. ...Combined, the contribution of E …
Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis.
Li R, Zhang D, Han Y, Chen K, Guo W, Chen Y, Wang S. Li R, et al. Int J Mol Sci. 2023 Feb 8;24(4):3415. doi: 10.3390/ijms24043415. Int J Mol Sci. 2023. PMID: 36834826 Free PMC article.
Mechanistically, this neddylation enhanced the kinase activity of EphB1 by the prevention of its degradation, thereby promoting the proliferation, migration, and activation of HSCs. Our findings revealed the involvement of EphB1 in the development of liver fibrosis …
Mechanistically, this neddylation enhanced the kinase activity of EphB1 by the prevention of its degradation, thereby promoting the p …
EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.
Xie Y, Zhang L, Wang L, Chen B, Guo X, Yang Y, Shi W, Chen A, Yi J, Tang J, Xiang J. Xie Y, et al. Cancer Lett. 2024 Feb 1;582:216567. doi: 10.1016/j.canlet.2023.216567. Epub 2023 Dec 7. Cancer Lett. 2024. PMID: 38070822 Free article.
In this study, we found compromised differentiation and maturation of DCs in EphB1(-/-) mice bearing lung adenocarcinoma syngeneic tumors. Our in vitro assays revealed that EphB1 phosphorylation induced DC differentiation and maturation. Cox-2, a key enzyme involved …
In this study, we found compromised differentiation and maturation of DCs in EphB1(-/-) mice bearing lung adenocarcinoma syngeneic tu …
Ligand-independent EphB1 signaling mediates TGF-beta-activated CDH2 and promotes lung cancer cell invasion and migration.
Wang L, Peng Q, Sai B, Zheng L, Xu J, Yin N, Feng X, Xiang J. Wang L, et al. J Cancer. 2020 Apr 7;11(14):4123-4131. doi: 10.7150/jca.44576. eCollection 2020. J Cancer. 2020. PMID: 32368295 Free PMC article.
The migration and invasion of lung cancer cells were assessed by a transwell assay. The activation of EphB1 signaling was assessed by western blot and real-time PCR. The EphB1 mutant was used to evaluate the effect of phosphorylation of EphB1. ...Conclusion: …
The migration and invasion of lung cancer cells were assessed by a transwell assay. The activation of EphB1 signaling was assessed by …
EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells.
Assali A, Chenaux G, Cho JY, Berto S, Ehrlich NA, Cowan CW. Assali A, et al. Development. 2024 Mar 1;151(5):dev201439. doi: 10.1242/dev.201439. Epub 2024 Feb 28. Development. 2024. PMID: 38345254 Free PMC article.
EphB1 is required for proper guidance of cortical axon projections during brain development, but how EphB1 regulates this process remains unclear. We show here that EphB1 conditional knockout (cKO) in GABAergic cells (Vgat-Cre), but not in cortical excitatory …
EphB1 is required for proper guidance of cortical axon projections during brain development, but how EphB1 regulates this proc …
EphB1 associates with Grb7 and regulates cell migration.
Han DC, Shen TL, Miao H, Wang B, Guan JL. Han DC, et al. J Biol Chem. 2002 Nov 22;277(47):45655-61. doi: 10.1074/jbc.M203165200. Epub 2002 Sep 9. J Biol Chem. 2002. PMID: 12223469 Free article.
Furthermore, Tyr-928 of EphB1 was identified as the primary binding site for Grb7. Stimulation of endogenous EphB1 in embryonal carcinoma P19 cells with its ligand ephrinB1 increased its association with Grb7, which is consistent with a role for the autophosphorylat …
Furthermore, Tyr-928 of EphB1 was identified as the primary binding site for Grb7. Stimulation of endogenous EphB1 in embryona …
276 results