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87 results

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Page 1
eIF3d controls the persistent integrated stress response.
Mukhopadhyay S, Amodeo ME, Lee ASY. Mukhopadhyay S, et al. Mol Cell. 2023 Sep 21;83(18):3303-3313.e6. doi: 10.1016/j.molcel.2023.08.008. Epub 2023 Sep 7. Mol Cell. 2023. PMID: 37683648
We find that during persistent stress, eIF3d activates the translation of the kinase GCN2, inducing eIF2alpha phosphorylation and inhibiting general protein synthesis. In parallel, eIF3d upregulates the m(6)A demethylase ALKBH5 to drive 5' UTR-specific demethylation …
We find that during persistent stress, eIF3d activates the translation of the kinase GCN2, inducing eIF2alpha phosphorylation and inh …
eIF3d: A driver of noncanonical cap-dependent translation of specific mRNAs and a trigger of biological/pathological processes.
Ma S, Liu JY, Zhang JT. Ma S, et al. J Biol Chem. 2023 May;299(5):104658. doi: 10.1016/j.jbc.2023.104658. Epub 2023 Mar 29. J Biol Chem. 2023. PMID: 36997088 Free PMC article. Review.
Compared with other eIF3 subunits, eIF3d is relatively understudied. However, recent progress in studying eIF3d has revealed a number of intriguing findings on its role in maintaining eIF3 complex integrity, global protein synthesis, and in biological and pathologic …
Compared with other eIF3 subunits, eIF3d is relatively understudied. However, recent progress in studying eIF3d has revealed a …
EIF3D promotes resistance to 5-fluorouracil in colorectal cancer through upregulating RUVBL1.
Li C, Lu K, Yang C, Du W, Liang Z. Li C, et al. J Clin Lab Anal. 2023 Jan;37(2):e24825. doi: 10.1002/jcla.24825. Epub 2023 Jan 2. J Clin Lab Anal. 2023. PMID: 36592991 Free PMC article.
BACKGROUND: As EIF3D is oncogenic in colorectal cancer (CRC) and is associated with multidrug resistance, this study aims to investigate whether and how EIF3D regulates resistance to 5-fluorouracil (5-Fu) in CRC. METHODS: EIF3D-associated genes in CRC were pr …
BACKGROUND: As EIF3D is oncogenic in colorectal cancer (CRC) and is associated with multidrug resistance, this study aims to investig …
EIF3D promoted cervical carcinoma through Warburg effect by interacting with GRP78.
Liu Q, Liu J, Zheng D, Zhang R, Xiang Y, Xu F, Zhou X, Qin J. Liu Q, et al. J Obstet Gynaecol. 2023 Dec;43(1):2130200. doi: 10.1080/01443615.2022.2130200. Epub 2022 Oct 20. J Obstet Gynaecol. 2023. PMID: 36264610 Free article.
Disease-free survival (DFS) and overall surviva (OS) of EIF3D lower expression in patients with cervical carcinoma was higher than those of EIF3D higher expression. ...EIF3D promoted cell growth and Warburg effect in vitro model of cervical carcinoma. ...
Disease-free survival (DFS) and overall surviva (OS) of EIF3D lower expression in patients with cervical carcinoma was higher than th …
eIF3d directs the integrated stress response.
Carim S. Carim S. Nat Cell Biol. 2023 Oct;25(10):1405. doi: 10.1038/s41556-023-01261-2. Nat Cell Biol. 2023. PMID: 37821669 No abstract available.
EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway.
Li X, Wang Z, Liu G, Guo J. Li X, et al. Reprod Toxicol. 2021 Oct;105:166-174. doi: 10.1016/j.reprotox.2021.09.006. Epub 2021 Sep 11. Reprod Toxicol. 2021. PMID: 34520790
EIF3D was selected in this study. EIF3D was upregulated in placentas tissues collected from patients with PE. ...Besides, the concentration of ANG-1, and the ratios of phosphorylated-ERK1/2 and phosphorylated-MEK1/MEK1 were also markedly lowered by EIF3D upre …
EIF3D was selected in this study. EIF3D was upregulated in placentas tissues collected from patients with PE. ...Besides, the …
mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching.
Shin S, Han MJ, Jedrychowski MP, Zhang Z, Shokat KM, Plas DR, Dephoure N, Yoon SO. Shin S, et al. Cell Rep. 2023 Aug 29;42(8):112868. doi: 10.1016/j.celrep.2023.112868. Epub 2023 Jul 25. Cell Rep. 2023. PMID: 37494188 Free PMC article.
Here, we reveal that mTOR targeting inhibits eIF4E-mediated cap-dependent translation, but feedback signaling activates a translation initiation factor, eukaryotic translation initiation factor 3D (eIF3D), to sustain alternative non-canonical translation mechanisms. Import …
Here, we reveal that mTOR targeting inhibits eIF4E-mediated cap-dependent translation, but feedback signaling activates a translation initia …
Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function.
Pan Y, Zhang ZN, Yin LB, Fu YJ, Jiang YJ, Shang H. Pan Y, et al. J Transl Med. 2019 May 22;17(1):167. doi: 10.1186/s12967-019-1925-0. J Transl Med. 2019. PMID: 31118081 Free PMC article.
Additionally, to examine the effect of eIF3d on CD8+ T cell function, eIF3d expression was inhibited alone or in combination with SOCS-7 knockdown by siRNA in isolated CD8+ T cells. ...Inhibited expression of eIF3d caused enhanced expression of SOCS-7, and in …
Additionally, to examine the effect of eIF3d on CD8+ T cell function, eIF3d expression was inhibited alone or in combination w …
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11.
Zhang W, Sun Y, Bai L, Zhi L, Yang Y, Zhao Q, Chen C, Qi Y, Gao W, He W, Wang L, Chen D, Fan S, Chen H, Piao HL, Qiao Q, Xu Z, Zhang J, Zhao J, Zhang S, Yin Y, Peng C, Li X, Liu Q, Liu H, Wang Y. Zhang W, et al. J Clin Invest. 2021 Nov 15;131(22):e152067. doi: 10.1172/JCI152067. J Clin Invest. 2021. PMID: 34609966 Free PMC article.
Mechanistically, RBMS1 interacted with the translation initiation factor eIF3d directly to bridge the 3'- and 5'-UTR of SLC7A11. RBMS1 ablation inhibited the translation of SLC7A11, reduced SLC7A11-mediated cystine uptake, and promoted ferroptosis. ...
Mechanistically, RBMS1 interacted with the translation initiation factor eIF3d directly to bridge the 3'- and 5'-UTR of SLC7A11. RBMS …
An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress.
Thompson L, Depledge DP, Burgess HM, Mohr I. Thompson L, et al. Cell Rep. 2022 May 3;39(5):110767. doi: 10.1016/j.celrep.2022.110767. Cell Rep. 2022. PMID: 35508137 Free PMC article.
This reveals a strategy whereby cellular eIF3d-dependent protein production is hijacked to exploit virus-induced ER stress. Moreover, it establishes how switching between eIF4E and eIF3d-responsive cap-dependent translation can differentially tune virus and host gen …
This reveals a strategy whereby cellular eIF3d-dependent protein production is hijacked to exploit virus-induced ER stress. Moreover, …
87 results