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1993 1
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282 results

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Page 1
DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress.
Yepuri G, Ramirez LM, Theophall GG, Reverdatto SV, Quadri N, Hasan SN, Bu L, Thiagarajan D, Wilson R, Díez RL, Gugger PF, Mangar K, Narula N, Katz SD, Zhou B, Li H, Stotland AB, Gottlieb RA, Schmidt AM, Shekhtman A, Ramasamy R. Yepuri G, et al. Nat Commun. 2023 Oct 30;14(1):6900. doi: 10.1038/s41467-023-42521-x. Nat Commun. 2023. PMID: 37903764 Free PMC article.
Introduction of synthetic linker construct, which shorten the mitochondria-SR/ER distance, mitigated the molecular and functional benefits of DIAPH1 silencing in ischemia. This work establishes fundamental roles for DIAPH1-MFN2 interaction in the regulation of mitoc …
Introduction of synthetic linker construct, which shorten the mitochondria-SR/ER distance, mitigated the molecular and functional benefits o …
DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice.
Senatus L, Egaña-Gorroño L, López-Díez R, Bergaya S, Aranda JF, Amengual J, Arivazhagan L, Manigrasso MB, Yepuri G, Nimma R, Mangar KN, Bernadin R, Zhou B, Gugger PF, Li H, Friedman RA, Theise ND, Shekhtman A, Fisher EA, Ramasamy R, Schmidt AM. Senatus L, et al. Commun Biol. 2023 Mar 17;6(1):280. doi: 10.1038/s42003-023-04643-2. Commun Biol. 2023. PMID: 36932214 Free PMC article.
We intercrossed atherosclerosis-prone Ldlr(-/-) mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks. Compared to male Ldlr(-/-) mice, male Ldlr(-/-) Diaph1(-/-) mice displayed significantly less atherosclerosis, in parallel with lower plasma conce …
We intercrossed atherosclerosis-prone Ldlr(-/-) mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks. Compared to m …
WTAP-mediated m(6)A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis.
Li ZX, Zheng ZQ, Yang PY, Lin L, Zhou GQ, Lv JW, Zhang LL, Chen F, Li YQ, Wu CF, Li F, Ma J, Liu N, Sun Y. Li ZX, et al. Cell Death Differ. 2022 Jun;29(6):1137-1151. doi: 10.1038/s41418-021-00905-w. Epub 2022 Jan 8. Cell Death Differ. 2022. PMID: 34999731 Free PMC article.
Functionally, WTAP was required for the growth and metastasis of NPC. Mechanistically, lncRNA DIAPH1-AS1 was identified as a bona fide m(6)A target of WTAP. WTAP-mediated m(6)A modification of DIAPH1-AS1 enhanced its stability relying on the m(6)A reader IGF2BP2-dep …
Functionally, WTAP was required for the growth and metastasis of NPC. Mechanistically, lncRNA DIAPH1-AS1 was identified as a bona fid …
DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease.
Kundishora AJ, Peters ST, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Smith H, Ocken J, Dunbar A, Nelson-Williams C, Haider S, Walker RL, Li B, Zhao H, Thumkeo D, Marlier A, Duy PQ, Diab NS, Reeves BC, Robert SM, Sujijantarat N, Stratman AN, Chen YH, Zhao S, Roszko I, Lu Q, Zhang B, Mane S, Castaldi C, López-Giráldez F, Knight JR, Bamshad MJ, Nickerson DA, Geschwind DH, Chen SL, Storm PB, Diluna ML, Matouk CC, Orbach DB, Alper SL, Smith ER, Lifton RP, Gunel M, Milewicz DM, Jin SC, Kahle KT. Kundishora AJ, et al. JAMA Neurol. 2021 Aug 1;78(8):993-1003. doi: 10.1001/jamaneurol.2021.1681. JAMA Neurol. 2021. PMID: 34125151 Free PMC article.
DIAPH1 and other MMD risk genes are enriched in mural cells of midgestational human brain. The DIAPH1 coexpression network converges in vascular cell actin cytoskeleton regulatory pathways. ...
DIAPH1 and other MMD risk genes are enriched in mural cells of midgestational human brain. The DIAPH1 coexpression network con …
Loss of DIAPH1 causes SCBMS, combined immunodeficiency, and mitochondrial dysfunction.
Kaustio M, Nayebzadeh N, Hinttala R, Tapiainen T, Åström P, Mamia K, Pernaa N, Lehtonen J, Glumoff V, Rahikkala E, Honkila M, Olsén P, Hassinen A, Polso M, Al Sukaiti N, Al Shekaili J, Al Kindi M, Al Hashmi N, Almusa H, Bulanova D, Haapaniemi E, Chen P, Suo-Palosaari M, Vieira P, Tuominen H, Kokkonen H, Al Macki N, Al Habsi H, Löppönen T, Rantala H, Pietiäinen V, Zhang SY, Renko M, Hautala T, Al Farsi T, Uusimaa J, Saarela J. Kaustio M, et al. J Allergy Clin Immunol. 2021 Aug;148(2):599-611. doi: 10.1016/j.jaci.2020.12.656. Epub 2021 Mar 1. J Allergy Clin Immunol. 2021. PMID: 33662367 Free article. Clinical Trial.
BACKGROUND: Homozygous loss of DIAPH1 results in seizures, cortical blindness, and microcephaly syndrome (SCBMS). We studied 5 Finnish and 2 Omani patients with loss of DIAPH1 presenting with SCBMS, mitochondrial dysfunction, and immunodeficiency. ...
BACKGROUND: Homozygous loss of DIAPH1 results in seizures, cortical blindness, and microcephaly syndrome (SCBMS). We studied 5 Finnis …
DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells.
Flat W, Borowski S, Paraschiakos T, Blechner C, Windhorst S. Flat W, et al. Biochem Pharmacol. 2022 Mar;197:114898. doi: 10.1016/j.bcp.2021.114898. Epub 2021 Dec 27. Biochem Pharmacol. 2022. PMID: 34968485
A possible explanation for this finding is that Ovca cells with high DIAPH1 levels are more sensitive to PTX. To examine this assumption, in this study the effect of DIAPH1 depletion on PTX-mediated cytotoxicity of OVCAR8 and OAW42 cells was analyzed. ...In vitro an …
A possible explanation for this finding is that Ovca cells with high DIAPH1 levels are more sensitive to PTX. To examine this assumpt …
New insights into RAGE/Diaph1 interaction as a modulator of actin cytoskeleton dynamics in peripheral nervous system in long-term hyperglycaemia.
Zglejc-Waszak K, Pomianowski A, Wojtkiewicz J, Banach M, Juranek JK. Zglejc-Waszak K, et al. Eur J Neurosci. 2023 May;57(10):1642-1656. doi: 10.1111/ejn.15991. Epub 2023 Apr 26. Eur J Neurosci. 2023. PMID: 37070486 Review.
This review focuses on receptor for advanced glycation endproducts/diaphonous related formin 1 (RAGE/Diaph1) interaction as a modulator of actin cytoskeleton dynamics in peripheral nervous system (PNS) in diabetes. Deciphering the complex molecular interactions between RAG …
This review focuses on receptor for advanced glycation endproducts/diaphonous related formin 1 (RAGE/Diaph1) interaction as a modulat …
The RAGE/DIAPH1 Signaling Axis & Implications for the Pathogenesis of Diabetic Complications.
Ramasamy R, Shekhtman A, Schmidt AM. Ramasamy R, et al. Int J Mol Sci. 2022 Apr 21;23(9):4579. doi: 10.3390/ijms23094579. Int J Mol Sci. 2022. PMID: 35562970 Free PMC article. Review.
Increasing evidence links the RAGE (receptor for advanced glycation end products)/DIAPH1 (Diaphanous 1) signaling axis to the pathogenesis of diabetic complications. ...This review focuses on recent examples of highlights and updates to the pathobiology of RAGE and DIAP …
Increasing evidence links the RAGE (receptor for advanced glycation end products)/DIAPH1 (Diaphanous 1) signaling axis to the pathoge …
Association between DIAPH1 variant and posterior circulation involvement with Moyamoya disease.
He S, Hao X, Liu Z, Wang Y, Zhang J, Wang X, Di F, Wang R, Zhao Y. He S, et al. Sci Rep. 2023 Jul 3;13(1):10732. doi: 10.1038/s41598-023-37665-1. Sci Rep. 2023. PMID: 37400591 Free PMC article.
Moyamoya disease (MMD) is a chronic and progressive cerebrovascular stenosis or occlusive disease that occurs near Willis blood vessels. The aim of this study was to investigate the mutation of DIAPH1 in Asian population, and to compare the angiographic features of MMD pat …
Moyamoya disease (MMD) is a chronic and progressive cerebrovascular stenosis or occlusive disease that occurs near Willis blood vessels. The …
DIAPH1 regulates ciliogenesis and trafficking in primary cilia.
Palander O, Trimble WS. Palander O, et al. FASEB J. 2020 Dec;34(12):16516-16535. doi: 10.1096/fj.202001178R. Epub 2020 Oct 30. FASEB J. 2020. PMID: 33124112
EB1 and EB3 have previously been implicated in cilia biogenesis to carry out centrosome-related functions. However, the role of DIAPH1 proteins had not been examined. Here we show that the depletion of DIAPH1 decreased ciliogenesis, cilia length, and reduced traffic …
EB1 and EB3 have previously been implicated in cilia biogenesis to carry out centrosome-related functions. However, the role of DIAPH1 …
282 results