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263 results

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Page 1
The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.
Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K. Di Stefano B, et al. Cell Stem Cell. 2019 Nov 7;25(5):622-638.e13. doi: 10.1016/j.stem.2019.08.018. Epub 2019 Oct 3. Cell Stem Cell. 2019. PMID: 31588046 Free PMC article.
Mechanistically, DDX6 mediates the translational suppression of target mRNAs in P-bodies. Upon loss of DDX6 activity, P-bodies dissolve and release mRNAs encoding fate-instructive transcription and chromatin factors that re-enter the ribosome pool. ...
Mechanistically, DDX6 mediates the translational suppression of target mRNAs in P-bodies. Upon loss of DDX6 activity, P-bodies …
RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.
Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM. Majerciak V, et al. Nucleic Acids Res. 2023 Sep 22;51(17):9337-9355. doi: 10.1093/nar/gkad585. Nucleic Acids Res. 2023. PMID: 37427791 Free PMC article.
DDX6 deficiency results in the formation of irregularly shaped 'hybrid' PB/SG granules with accumulated components of both PB and SG. Wild-type DDX6, but not its helicase mutant E247A, can rescue the separation of PB from SG in DDX6KO cells, indicating a requirement …
DDX6 deficiency results in the formation of irregularly shaped 'hybrid' PB/SG granules with accumulated components of both PB and SG. …
DDX6 and its orthologs as modulators of cellular and viral RNA expression.
Ostareck DH, Naarmann-de Vries IS, Ostareck-Lederer A. Ostareck DH, et al. Wiley Interdiscip Rev RNA. 2014 Sep-Oct;5(5):659-78. doi: 10.1002/wrna.1237. Epub 2014 Apr 30. Wiley Interdiscip Rev RNA. 2014. PMID: 24788243 Review.
DDX6 (Rck/p54), a member of the DEAD-box family of helicases, is highly conserved from unicellular eukaryotes to vertebrates. ...DDX6 and its orthologs have versatile functions in mRNA metabolism, which characterize them as important post-transcriptional regulators …
DDX6 (Rck/p54), a member of the DEAD-box family of helicases, is highly conserved from unicellular eukaryotes to vertebrates. ...D …
DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
Inagaki H, Hosoda N, Hoshino SI. Inagaki H, et al. Biochem Biophys Res Commun. 2021 May 14;553:9-16. doi: 10.1016/j.bbrc.2021.03.066. Epub 2021 Mar 20. Biochem Biophys Res Commun. 2021. PMID: 33756349
Analysis of Ataxin-2 interactome using LC-MS/MS revealed prominent interaction with the DEAD-box RNA helicase DDX6. DDX6 interacted with components of the Ataxin-2 polyadenylation machinery; Ataxin-2, PABPC1 and PAPD4. ...In contrast, Ataxin-2 target mRNAs with shor …
Analysis of Ataxin-2 interactome using LC-MS/MS revealed prominent interaction with the DEAD-box RNA helicase DDX6. DDX6 inter …
DDX6 is involved in the pathogenesis of inflammatory diseases via NF-kappaB activation.
Naito S, Tanaka H, Jiang JJ, Tarumi M, Hashimoto A, Tanaka Y, Murakami K, Kubota SI, Hojyo S, Hashimoto S, Murakami M. Naito S, et al. Biochem Biophys Res Commun. 2024 Apr 9;703:149666. doi: 10.1016/j.bbrc.2024.149666. Epub 2024 Feb 9. Biochem Biophys Res Commun. 2024. PMID: 38377944
We found that DDX6-silencing in non-immune cells suppressed the NF-kappaB pathway and inhibited activation of the IL-6 amplifier, while the forced expression of DDX6 enhanced NF-kappaB promoter activity independent of the RNA helicase activity of DDX6. ...Thu …
We found that DDX6-silencing in non-immune cells suppressed the NF-kappaB pathway and inhibited activation of the IL-6 amplifier, whi …
Antagonism between DDX6 and PI3K-AKT signaling is an oocyte-intrinsic mechanism controlling primordial follicle growth.
Kato Y, Saga Y. Kato Y, et al. Biol Reprod. 2023 Jul 11;109(1):73-82. doi: 10.1093/biolre/ioad043. Biol Reprod. 2023. PMID: 37067907
DDX6 forms P-body-like cytoplasmic foci in oocytes, which colocalize to a P-body component, DCP1A. Interestingly, the P-body-like granules predominantly assemble in primordial follicles, but disperse once follicle growth is initiated, suggesting that they play a role in th …
DDX6 forms P-body-like cytoplasmic foci in oocytes, which colocalize to a P-body component, DCP1A. Interestingly, the P-body-like gra …
miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells.
Ghashghaei M, Le CT, Shaalan H, Escano L, Yue M, Arsalan A, Rouhi A, Nguyen TA, Vu LP. Ghashghaei M, et al. Blood Adv. 2023 Aug 8;7(15):3846-3861. doi: 10.1182/bloodadvances.2022008123. Blood Adv. 2023. PMID: 36322827 Free PMC article.
Genome-wide assessment of DDX6-binding transcripts and gene expression profiling of DDX6-depleted cells revealed TXNIP, a tumor suppressor, as the functional downstream target of DDX6. Overall, our study identified DDX6 as a posttranscriptional regulat …
Genome-wide assessment of DDX6-binding transcripts and gene expression profiling of DDX6-depleted cells revealed TXNIP, a tumo …
RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal Differentiation in Human Cells.
Shih CY, Chen YC, Lin HY, Chu CY. Shih CY, et al. Int J Mol Sci. 2023 Feb 6;24(4):3197. doi: 10.3390/ijms24043197. Int J Mol Sci. 2023. PMID: 36834609 Free PMC article.
To decipher the potential role of DDX6 in the nucleus, we performed mass spectrometry analysis of immunoprecipitated DDX6 from a HeLa nuclear extract. We found that adenosine deaminases that act on RNA 1 (ADAR1) interact with DDX6 in the nucleus. Utilizing ou …
To decipher the potential role of DDX6 in the nucleus, we performed mass spectrometry analysis of immunoprecipitated DDX6 from …
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Lumb JH, Li Q, Popov LM, Ding S, Keith MT, Merrill BD, Greenberg HB, Li JB, Carette JE. Lumb JH, et al. Cell Rep. 2017 Jul 25;20(4):819-831. doi: 10.1016/j.celrep.2017.06.085. Cell Rep. 2017. PMID: 28746868 Free PMC article.
Through a genome-wide genetic screen, we identified DEAD-box helicase 6 (DDX6) as a suppressor of ISGs. Genetic ablation of DDX6 induced global upregulation of ISGs and other immune genes. ...DDX6 is distinct among DExD/H helicases that regulate the antiviral …
Through a genome-wide genetic screen, we identified DEAD-box helicase 6 (DDX6) as a suppressor of ISGs. Genetic ablation of DDX6 …
The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing.
Kim J, Muraoka M, Okada H, Toyoda A, Ajima R, Saga Y. Kim J, et al. PLoS Genet. 2022 Oct 5;18(10):e1009967. doi: 10.1371/journal.pgen.1009967. eCollection 2022 Oct. PLoS Genet. 2022. PMID: 36197846 Free PMC article.
We here show that DDX6 enables proper cell lineage specification from pluripotent cells by analyzing Ddx6 knockout (KO) mouse embryos and employing an in vitro epiblast-like cell (EpiLC) induction system. ...Overall, this study delineates how DDX6 affects the …
We here show that DDX6 enables proper cell lineage specification from pluripotent cells by analyzing Ddx6 knockout (KO) mouse …
263 results