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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1994 3
1995 5
1996 3
1997 4
1998 1
1999 2
2000 9
2001 11
2002 5
2003 9
2004 9
2005 10
2006 22
2007 25
2008 19
2009 17
2010 27
2011 28
2012 26
2013 32
2014 25
2015 36
2016 38
2017 37
2018 40
2019 60
2020 62
2021 69
2022 70
2023 61
2024 18

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695 results

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Page 1
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.
Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. Su H, et al. Nature. 2022 Oct;610(7931):366-372. doi: 10.1038/s41586-022-05169-z. Epub 2022 Oct 5. Nature. 2022. PMID: 36198801 Free PMC article.
Here we show that matrix-metalloprotease-cleaved Col I (cCol I) and intact Col I (iCol I) exert opposing effects on PDAC bioenergetics, macropinocytosis, tumour growth and metastasis. Whereas cCol I activates discoidin domain receptor 1 (DDR1)-NF-kappaB-p62-NRF2 signalling …
Here we show that matrix-metalloprotease-cleaved Col I (cCol I) and intact Col I (iCol I) exert opposing effects on PDAC bioenergetics, macr …
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
Sun X, Wu B, Chiang HC, Deng H, Zhang X, Xiong W, Liu J, Rozeboom AM, Harris BT, Blommaert E, Gomez A, Garcia RE, Zhou Y, Mitra P, Prevost M, Zhang D, Banik D, Isaacs C, Berry D, Lai C, Chaldekas K, Latham PS, Brantner CA, Popratiloff A, Jin VX, Zhang N, Hu Y, Pujana MA, Curiel TJ, An Z, Li R. Sun X, et al. Nature. 2021 Nov;599(7886):673-678. doi: 10.1038/s41586-021-04057-2. Epub 2021 Nov 3. Nature. 2021. PMID: 34732895 Free PMC article.
The DDR1 extracellular domain (DDR1-ECD), but not its intracellular kinase domain, is required for immune exclusion. Membrane-untethered DDR1-ECD is sufficient to rescue the growth of Ddr1-knockout tumours in immunocompetent hosts. ...
The DDR1 extracellular domain (DDR1-ECD), but not its intracellular kinase domain, is required for immune exclusion. Membrane- …
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis.
Deng J, Kang Y, Cheng CC, Li X, Dai B, Katz MH, Men T, Kim MP, Koay EA, Huang H, Brekken RA, Fleming JB. Deng J, et al. JCI Insight. 2021 Sep 8;6(17):e146133. doi: 10.1172/jci.insight.146133. JCI Insight. 2021. PMID: 34237033 Free PMC article.
A central mediator of protumorigenic collagen signaling is the receptor tyrosine kinase discoid domain receptor 1 (DDR1). DDR1 is a critical driver of a mesenchymal and invasive cancer cell PDAC phenotype. Previous studies have demonstrated that genetic or pharmacol …
A central mediator of protumorigenic collagen signaling is the receptor tyrosine kinase discoid domain receptor 1 (DDR1). DDR1 …
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
Xiong YX, Zhang XC, Zhu JH, Zhang YX, Pan YL, Wu Y, Zhao JP, Liu JJ, Lu YX, Liang HF, Zhang ZG, Zhang WG. Xiong YX, et al. Cell Death Differ. 2023 Jul;30(7):1648-1665. doi: 10.1038/s41418-023-01166-5. Epub 2023 Apr 28. Cell Death Differ. 2023. PMID: 37117273
Collagen I-induced DDR1 activation enhanced HCC cell stemness in vitro and in vivo. Mechanistically, DDR1 interacts with CD44, which acts as a co-receptor that amplifies collagen I-induced DDR1 signaling, and collagen I-DDR1 signaling antagonized Hippo …
Collagen I-induced DDR1 activation enhanced HCC cell stemness in vitro and in vivo. Mechanistically, DDR1 interacts with CD44, …
New target DDR1: A "double-edged sword" in solid tumors.
Tian Y, Bai F, Zhang D. Tian Y, et al. Biochim Biophys Acta Rev Cancer. 2023 Jan;1878(1):188829. doi: 10.1016/j.bbcan.2022.188829. Epub 2022 Nov 7. Biochim Biophys Acta Rev Cancer. 2023. PMID: 36356724 Review.
Hence, here, we focus on a new target, DDR1, which may be a "double-edged sword" of human solid tumors. In this review, we provide a comprehensive overview of how DDR1 acts as a "double-edged sword" in cancer. First, we briefly introduce the structure and normal phy …
Hence, here, we focus on a new target, DDR1, which may be a "double-edged sword" of human solid tumors. In this review, we provide a …
Multifaceted collagen-DDR1 signaling in cancer.
Su H, Karin M. Su H, et al. Trends Cell Biol. 2024 May;34(5):406-415. doi: 10.1016/j.tcb.2023.08.003. Epub 2023 Sep 12. Trends Cell Biol. 2024. PMID: 37709651 Review.
This review focuses on DDR1 to NRF2 signaling, its modulation of autophagy and macropinocytosis (MP), and its role in cancer and other diseases. Elucidating the regulation of DDR1 activity and expression under different pathophysiological conditions will facilitate …
This review focuses on DDR1 to NRF2 signaling, its modulation of autophagy and macropinocytosis (MP), and its role in cancer and othe …
Expression of DDR1 in the CNS and in myelinating oligodendrocytes.
Vilella E, Gas C, Garcia-Ruiz B, Rivera FJ. Vilella E, et al. Biochim Biophys Acta Mol Cell Res. 2019 Nov;1866(11):118483. doi: 10.1016/j.bbamcr.2019.04.010. Epub 2019 May 18. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31108116 Free article. Review.
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase receptor that is activated by fibrillar collagens. Here, we review the expression and role of DDR1 in the central nervous system (CNS). In a murine model, DDR1 is expressed in oligodendrocytes in the dev …
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase receptor that is activated by fibrillar collagens. Here, we review the expres …
Liquid-Liquid Phase Separation of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening.
Liu J, Wang J, Liu Y, Xie SA, Zhang J, Zhao C, Zhou Y, Pang W, Yao W, Peng Q, Wang X, Zhou J. Liu J, et al. Circ Res. 2023 Jan 6;132(1):87-105. doi: 10.1161/CIRCRESAHA.122.322113. Epub 2022 Dec 8. Circ Res. 2023. PMID: 36475898
We utilized polyacrylamide gels of varying stiffness or the DDR1 ligand, type I collagen, to stimulate the cells. We employed multiple molecular biological techniques to explore the role of DDR1 in controlling the Hippo pathway and to determine the mechanistic basis …
We utilized polyacrylamide gels of varying stiffness or the DDR1 ligand, type I collagen, to stimulate the cells. We employed multipl …
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH, Zent R, Pozzi A. Borza CM, et al. JCI Insight. 2022 Feb 8;7(3):e150887. doi: 10.1172/jci.insight.150887. JCI Insight. 2022. PMID: 34941574 Free PMC article.
Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase activated by collagen, contributes to chronic kidney disease. ...DDR1-induced BCR phosphorylation or BCR downregulation increased MCP-1 secretion, suggesting that BCR negatively regulates the levels of M …
Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase activated by collagen, contributes to chronic kidney disease. ...DD …
DDR1 role in fibrosis and its pharmacological targeting.
Moll S, Desmoulière A, Moeller MJ, Pache JC, Badi L, Arcadu F, Richter H, Satz A, Uhles S, Cavalli A, Drawnel F, Scapozza L, Prunotto M. Moll S, et al. Biochim Biophys Acta Mol Cell Res. 2019 Nov;1866(11):118474. doi: 10.1016/j.bbamcr.2019.04.004. Epub 2019 Apr 5. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30954571 Free article. Review.
Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. ...The present review article focuses on: a) detailing the evidence for a role of DDR1 as an anti-fibrotic target in different organs, b) clari …
Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. ...The pre …
695 results