Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2008 1
2010 1
2011 6
2012 2
2013 2
2014 2
2015 4
2016 2
2017 3
2018 3
2019 5
2020 7
2021 3
2022 3
2023 2
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

47 results

Results by year

Filters applied: . Clear all
Page 1
CUEDC2: multifunctional roles in carcinogenesis.
Xiao JB, Leng AM, Zhang YQ, Wen Z, He J, Ye GN. Xiao JB, et al. Front Biosci (Landmark Ed). 2019 Mar 1;24(5):935-946. doi: 10.2741/4759. Front Biosci (Landmark Ed). 2019. PMID: 30844721 Free article. Review.
The ubiquitously expressed multifunctional protein, CUEDC2 (CUE domain-containing 2), is involved in many physiological and pathological processes, including the cell cycle regulation and inflammation. ...In this review, we examine the expression of CUEDC2 in variou …
The ubiquitously expressed multifunctional protein, CUEDC2 (CUE domain-containing 2), is involved in many physiological and pathologi …
CUEDC2: an emerging key player in inflammation and tumorigenesis.
Man J, Zhang X. Man J, et al. Protein Cell. 2011 Sep;2(9):699-703. doi: 10.1007/s13238-011-1089-z. Epub 2011 Oct 6. Protein Cell. 2011. PMID: 21976060 Free PMC article. Review.
CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibition. ...In this review, current knowledge on the multi-functions of CUEDC2 in normal processes and tumorigenesis are di …
CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from chec …
CUEDC2 Drives beta-Catenin Nuclear Translocation and Promotes Triple-Negative Breast Cancer Tumorigenesis.
Han S, Hao H, Han H, Xue D, Jiao Y, Xie Y, Xu Y, Huangfu L, Fu J, Wang S, Sun H, Li P, Zhou Q. Han S, et al. Cells. 2022 Sep 29;11(19):3067. doi: 10.3390/cells11193067. Cells. 2022. PMID: 36231027 Free PMC article.
More importantly, an 11-amino-acid competitive peptide targeting the CUE domain in CUEDC2 blocked the interactions of CUEDC2 and beta-catenin and abrogated the malignant phenotype of TNBC cells in vitro and in vivo. ...Targeting the interactions of CUEDC2 and …
More importantly, an 11-amino-acid competitive peptide targeting the CUE domain in CUEDC2 blocked the interactions of CUEDC2 a …
CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway.
Kim JW, Oh SH, Lee MN, Song JH, Jeong BC, Yang JW, Piao X, Zang Y, Ryu JH, Koh JT. Kim JW, et al. Cell Death Dis. 2020 May 11;11(5):344. doi: 10.1038/s41419-020-2562-5. Cell Death Dis. 2020. PMID: 32393737 Free PMC article.
This study investigated the role of CUEDC2 in osteogenesis and its underlying molecular mechanisms. We found that CUEDC2 is expressed in bone tissues. ...The overexpression of CUEDC2 suppressed the osteogenic differentiation of precursor cells, while the knoc …
This study investigated the role of CUEDC2 in osteogenesis and its underlying molecular mechanisms. We found that CUEDC2 is ex …
MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness.
Ghatak D, Datta A, Roychowdhury T, Chattopadhyay S, Roychoudhury S. Ghatak D, et al. Mol Cancer Res. 2021 Oct;19(10):1635-1650. doi: 10.1158/1541-7786.MCR-20-0717. Epub 2021 Jul 13. Mol Cancer Res. 2021. PMID: 34257080
Our experimental results suggest that miR-324-5p-induced CSC phenotypes stem from the downregulation of CUEDC2, a downstream target gene of miR-324-5p. Accordingly, CUEDC2 complementation diminishes elevated CSC marker expression in miR-324-5p-overexpressing cancer …
Our experimental results suggest that miR-324-5p-induced CSC phenotypes stem from the downregulation of CUEDC2, a downstream target g …
CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability.
Jian Z, Liang B, Pan X, Xu G, Guo SS, Li T, Zhou T, Xiao YB, Li AL. Jian Z, et al. EMBO Mol Med. 2016 Jul 1;8(7):813-29. doi: 10.15252/emmm.201506010. Print 2016 Jul. EMBO Mol Med. 2016. PMID: 27286733 Free PMC article.
Cuedc2(-/-) cardiomyocytes exhibited a greater resistance to oxidative stress-induced cell death. ...Ablation of CUEDC2 upregulated the protein level of GPX1 in the heart significantly. ...
Cuedc2(-/-) cardiomyocytes exhibited a greater resistance to oxidative stress-induced cell death. ...Ablation of CUEDC2 upregu …
CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult.
Huang Y, Xiao X, Xiao H, Hu Z, Tan F. Huang Y, et al. Aging (Albany NY). 2021 Jan 20;13(3):4335-4356. doi: 10.18632/aging.202394. Epub 2021 Jan 20. Aging (Albany NY). 2021. PMID: 33494071 Free PMC article.
We also evaluated the possible mechanisms involved in cerebral I/R condition. Cerebral I/R stimulation suppressed CUEDC2 levels in brain tissues and neurons. siRNA-CUEDC2 in neurons significantly inhibited cerebral I/R-induced apoptosis and oxidative stress levels i …
We also evaluated the possible mechanisms involved in cerebral I/R condition. Cerebral I/R stimulation suppressed CUEDC2 levels in br …
Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance.
Xu S, Huang S, Li D, Zou Q, Yuan Y, Yang Z. Xu S, et al. Biomark Med. 2020 Nov;14(16):1573-1584. doi: 10.2217/bmm-2020-0321. Epub 2020 Sep 22. Biomark Med. 2020. PMID: 32960074

Result: The expression of ADAM19 and CUEDC2 were significantly higher in EHCC (p < 0.05). ADAM19 expression was positive correlated with CUEDC2 expression in EHCC (p < 0.05). The overall survival time of those with positive expression of ADAM19 and CUEDC2

…

Result: The expression of ADAM19 and CUEDC2 were significantly higher in EHCC (p < 0.05). ADAM19 expression was positive correlate

…
Molecular crosstalk between CUEDC2 and ERalpha influences the clinical outcome by regulating mitosis in breast cancer.
Roy S, Saha S, Dhar D, Chakraborty P, Singha Roy K, Mukherjee C, Gupta A, Bhattacharyya S, Roy A, Sengupta S, Roychoudhury S, Nath S. Roy S, et al. Cancer Gene Ther. 2022 Nov;29(11):1697-1706. doi: 10.1038/s41417-022-00494-x. Epub 2022 Jun 22. Cancer Gene Ther. 2022. PMID: 35732909
Higher level of CUEDC2 in ERalpha+ve breast cancer corresponded to poorer disease prognosis. ...We elucidated the importance of mitosis-specific phosphorylation of CUEDC2 in this process. Furthermore, upregulated CUEDC2 overrode mitotic arrest, increasing ane …
Higher level of CUEDC2 in ERalpha+ve breast cancer corresponded to poorer disease prognosis. ...We elucidated the importance of mitos …
CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
Zhang H, Chang G, Wang J, Lin Y, Ma L, Pang T. Zhang H, et al. Leuk Res. 2013 Nov;37(11):1583-91. doi: 10.1016/j.leukres.2013.08.019. Epub 2013 Sep 6. Leuk Res. 2013. PMID: 24125838
To study the role of CUEDC2 in chronic myeloid leukemia (CML), we explored the function of CUEDC2 in CML cells through using the CML cell line K562 and its imatinib resistant cells K562/G01. K562 cells expressed a relatively higher level of CUEDC2 compared to …
To study the role of CUEDC2 in chronic myeloid leukemia (CML), we explored the function of CUEDC2 in CML cells through using t …
47 results